A Review on the Role of miR-149-5p in the Carcinogenesis

Ghafouri‐Fard, Soudeh; Khoshbakht, Tayyebeh; Hussen, Bashdar Mahmud; Kadkhoda, Sepideh; Taheri, Mohammad; Tafrishinejad, Arash

doi:10.3390/ijms23010415

Cited by 16 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies indicate that miR-149-5p acts as a tumor suppressor and is downregulated in many human cancers. 16 For example, Wang et al reported that miR-149 is an independent prognostic factor for overall survival in CRC patients, and ectopic expression of miR-149-5p decreases tumor cell growth and invasion. 17 progression and metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…To determine the mechanism of action of circBGN, we searched for a potential target miRNA and identified miR‐149‐5p. Earlier studies indicate that miR‐149‐5p acts as a tumor suppressor and is downregulated in many human cancers 16 . For example, Wang et al reported that miR‐149 is an independent prognostic factor for overall survival in CRC patients, and ectopic expression of miR‐149‐5p decreases tumor cell growth and invasion 17 .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway

Peng

et al. 2022

The FASEB Journal

View full text Add to dashboard Cite

Circular RNAs participate in the pathogenesis of various tumors, including gastric cancer (GC). In this study, we investigated the role of circBGN in regulating proliferation and invasion of GC cells and elucidated the mechanism. The expression of circBGN was assessed by quantitative reverse‐transcription PCR and in situ hybridization. In addition, loss‐ and gain‐of‐function investigations in vitro and in vivo were performed to determine the biological functions of circBGN. Luciferase reporter assays and rescue experiments were applied to investigate the interaction between circBGN and miR‐149‐5p as well as the relationship between miR‐149‐5p and IL6. Our results showed that circBGN expression was significantly elevated in GC tissues and cells. Knockdown of circBGN dramatically suppressed GC cell proliferation and invasion in vitro. Xenograft experiments revealed that knockdown of circBGN delayed tumor growth in vivo. Furthermore, circBGN can directly bind to miR‐149‐5p, thereby preventing miR‐149‐5p from binding to its target mRNA [IL6 mRNA], thus activating IL6/STAT3 signaling pathway. Rescue assays indicated that circBGN regulates GC cell proliferation and invasion by upregulating miR‐149‐5p/IL6 axis output. Taken together, our investigation indicates that circBGN supports GC progression by activating IL6/STAT3 signaling pathway, thus pointing to a new possible therapeutic target in GC.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway

Peng

et al. 2022

The FASEB Journal

View full text Add to dashboard Cite

show abstract

“…[5] miR-149 is a miRNA with essential roles in carcinogenesis, it is encoded by MIR149 gene on 2q37.3, the most appreciated mechanism of miR-149-5p dysregulation in cancer cells is the sequestering effects of these lncRNAs and circRNAs on it. [6] miR-149 was shown to inhibit tumor cell proliferation, migration, and invasion in renal cell carcinoma, bladder cancer, GC, and colorectal cancer. [7] Previous experiment in GC has shown miR-149 regulates metabolic pathways through AKT1/mTOR axis.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, miR-149 has been shown to be tumor suppressor, the circCTNNA1/miR-149/FOXM1 axis has been suggested as a target for therapeutic interventions in colorectal cancer, miR-149-5p has also been shown to be sponged by other oncogenic noncoding RNAs such as PCAT1, DLGAP1-AS1, and circ5615 in colorectal cancer cells. [6] miRNA-149 was under-expressed in GC tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration. [8] Several studies investigated the role of miR-149 polymorphisms in the development of GC, [9–16] but the results are conflicting.…”

Section: Introductionmentioning

confidence: 99%

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

Zhong,

Luo,

et al. 2023

Medicine

View full text Add to dashboard Cite

Objective: Single nucleotide polymorphisms in microRNAs are believed to affect the occurrence and progression of cancer by altering the expression and biological functions of microRNAs. Several studies investigated the role of the miR-149 rs2292832 C>T polymorphism on the risk of gastric cancer (GC), but got conflicting results. Methods: We performed a comprehensive and systematic search through the PubMed MEDLINE, Google Scholar, Science Direct, Scopus, CNKI, and Web of science, 8 studies were included in the meta-analysis to determine whether miR-149 rs2292832 C>T polymorphism contributed to the risk of GC. Results: Pooled data indicated that miR-149 rs2292832 C>T polymorphism was not associated with GC risk. In the stratified analysis by ethnicity, miR-149 rs2292832 C>T polymorphism significantly increased GC risk under the allele comparison model (odds ratio [OR] = 1.27, 95% CI = 1.04–1.55, P heterogeneity = 0.18, P = .02), recessive model (OR = 1.44, 95% CI = 1.04–2.01, P heterogeneity = 0.19, P = .03) among Caucasians; but decreased GC risk under the allele comparison model (OR = 0.89, 95% CI = 0.81–0.98, P heterogeneity = 0.22, P = .02) and dominant model (OR = 0.82, 95% CI = 0.72–0.93, P heterogeneity = 0.15, P = .01) among Asian. Conclusion: Our meta-analysis suggests a positive correlation between miR-149 rs2292832 C>T polymorphism and GC development among Caucasians, but negative correlation among Asian population.

show abstract

“…For many years the role of miRNA is mostly associated with translation arrest. miRNAs have crucial roles in the developmental processes and have various biological functions ( Fu et al, 2013 ; Ghafouri-Fard et al, 2021a ; Hussen et al, 2021 ). The process of miRNA synthesis contains multiple steps with the final step being incorporation of either the 5p or 3p strands of the mature miRNA duplex into a complex, namely miRNA-induced silencing complex (miRISC).…”

Section: Introductionmentioning

confidence: 99%

A review on the importance of miRNA-135 in human diseases

et al. 2022

Self Cite

View full text Add to dashboard Cite

MicroRNA-135 (miR-135) is a microRNA which is involved in the pathoetiology of several neoplastic and non-neoplastic conditions. Both tumor suppressor and oncogenic roles have been reported for this miRNA. Studies in prostate, renal, gallbladder and nasopharyngeal cancers as well as glioma have shown down-regulation of miR-135 in cancerous tissues compared with controls. These studies have also shown the impact of miR-135 down-regulation on enhancement of cell proliferation and aggressive behavior. Meanwhile, miR-135 has been shown to be up-regulated in bladder, oral, colorectal and liver cancers. Studies in breast, gastric, lung and pancreatic cancers as well as head and neck squamous cell carcinoma have reported dual roles for miR-135. Dysregulation of miR-135 has also been noted in various non-neoplastic conditions such as Alzheimer’s disease, atherosclerosis, depression, diabetes, Parkinson, pulmonary arterial hypertension, nephrotic syndrome, endometriosis, epilepsy and allergic conditions. In the current review, we summarize the role of miR-135 in the carcinogenesis as well as development of other disorders.

show abstract

A Review on the Role of miR-149-5p in the Carcinogenesis

Cited by 16 publications

References 50 publications

circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway

circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway

Update on the association of miR-149 rs2292832 C>T polymorphism with gastric cancer risk: A meta-analysis study of gastrointestinal cancers

A review on the importance of miRNA-135 in human diseases

Contact Info

Product

Resources

About