A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

Sham, Tung-Ting; Chan, Chi-On; Wang, Youhua; Yang, Jian; Mok, Daniel K. W.; Chan, Shun‐Wan

doi:10.1155/2014/925302

Cited by 93 publications

(61 citation statements)

References 177 publications

(211 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since ancient times, RMR has long been recognized as a traditional Chinese medicine for improving food digestion and promoting blood circulation in China (Sham and other ). Its pharmaceutical function was stated in the ancient Chinese pharmacopeia, the Compendium of Materia Medica (Panda and other ).…”

Section: Rmr the Classical Achievement Of Monascus Fermentation In Ementioning

confidence: 99%

Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics

Chen

Zhou

et al. 2015

Comp Rev Food Sci Food Safe

199

154

View full text Add to dashboard Cite

Monascus spp. are filamentous fungi famous for their fermented products, especially red mold rice (RMR), a traditional fermented food in East Asian areas with a very long edible history documented back to the Han dynasty (BC 202-AD 220) in China. Nowadays, RMR and its related products involve a very large industry from artisanal traditional fermentations to food companies to medicine manufacturers, which are distributed worldwide. Modern studies have shown that Monascus spp. are able to produce abundant beneficial secondary metabolites, such as monacolins (cholesterollowering agents), γ -amino butyric acid (an antihypertensive substance), dimerumic acid (an antioxidant), and pigments (food-grade colorants), and some strains can also secrete citrinin, a nephrotoxic metabolite. Monascus-related studies have received much attention because of their wide applications. However, to our knowledge, no systematic review on the progress of Monascus research has ever been published. In this review, the progress of research on Monascus is summarized into 3 stages: Monascus fermentation, Monascus molecular biology, and Monascus genomics. This review covers the past history, current status, and future direction of Monascus research, contributing to a comprehensive understanding of Monascus research progress.

show abstract

Section: Rmr the Classical Achievement Of Monascus Fermentation In Ementioning

confidence: 99%

Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics

Chen

Zhou

et al. 2015

Comp Rev Food Sci Food Safe

199

154

View full text Add to dashboard Cite

show abstract

“…The present study utilizes the dried fruit extract of T. chebula as it was observed to have a good efficacy in radical scavenging activity (Saha and Verma, 2014). The diseases caused due to 'oxidative stress' which is initiated by Reactive Oxygen Species (ROS), produced as a byproduct of the electron transport in mitochondria is growing at an alarming rate (Saha and Verma, 2014). The ROS is considered to be an important target in the development of several anti-cancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Potential of Terminalia chebula by Hydrogen Peroxide Induced Oxidative Stress in THP-1 Cell Line

Minakshi¹,

Vasanth²,

Tanupriya³

et al. 2014

International J. of Botany

View full text Add to dashboard Cite

A B S T R A C T Diseases caused due to 'oxidative stress' initiated by Reactive Oxygen Species (ROS) is growing at an alarming rate. Several medicinal herbs explored till date were reported to possess numerous pharmacological properties used for combating different diseases. The present study was undertaken to investigate the inhibitory potential of Terminalia chebula by H 2 O 2 induced oxidative stress in THP-1 cell line and also the presence of the marker compounds in T. chebula was confirmed by High Performance Liquid Chromatography (HPLC). Intracellular quantification of ROS was done using a flow cytometer. The percentage of gallic acid and ellagic acid in the extract was performed by HPLC were found to be 4.84% w/w and 2.56% w/w, respectively. Pretreatment of cells with T. chebula extract significantly reduced the intracellular ROS production in a dose-dependent manner. The present study illustrates the effective role of T. chebula in reducing the ROS production which is a causative factor for several disorders. The results describe the possibility and potentiality of natural sources to inhibit the pathogenesis of different diseases caused due to oxidative stress.

show abstract

“…A decrease in the content of fatty acids is accompanied by a reduction in the synthesis of TG. 26,27) ACC and FAS, on the other hand, play a major role in the biosynthesis of fatty acids. ACC is the rate-limiting enzyme in the synthesis of fatty acids, which facilitates acetyl-CoA to generate malonyl-CoA, and fatty acids are formed by malonyl-CoA after a series of reactions.…”

Section: Discussionmentioning

confidence: 99%

The Anti-hyperlipidemia Effects of Raw <i>Polygonum multiflorum</i> Extract <i>in Vivo</i>

Xian

Liu

et al. 2017

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Polygonum multiflorum is widely used in the prevention and treatment of hyperlipidemia in traditional Chinese Medicine. In this study, the effects and relevant mechanisms of lipid-regulation by raw Polygonum multiflorum (RPM) were investigated. The results indicated that the basal plasma lipids, such as low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), were significantly decreased in RPM treatment groups compared with the model group, especially in the RPM high dose group. The key enzymes involved in lipid metabolism, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC) in plasma were generally reduced after oral administration, which was consistent with the transcription levels of their target genes. In addition, the hepatotoxicity of RPM was investigated, and RPM showed slightly less liver injury than that induced by simvastatin. Histological analysis indicated that the fat vacuoles and steatosis in hepatocytes were relieved after oral administration of RPM extract at a high dose of 16.2 g/kg, which was more obvious than that induced by simvastatin. These results revealed that RPM exerted its lipid-lowering effect by regulating the expression of related genes, and performed better than simvastatin in the treatment of hyperlipidemia. Key words raw Polygonum multiflorum; hyperlipidemia; lipid-lowering; hepatotoxicityHyperlipidemia is a common metabolic syndrome characterized by increased total cholesterol (TC), triglycerides (TG), and low-density lipoprotein cholesterol (LDL-C) and decreased high-density lipoprotein cholesterol (HDL-C) levels, 1) which facilitate endothelial dysfunction and atherogenesis, the major risk factor for cardiovascular disease.2) Statins are commonly used in clinical treatment as first-line lipid-lowering drugs, especially in the treatment of hyperlipidemia. They act to suppress the activities of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) and thus affect the formation of mevalonic acid, the rate-limiting step in the biosynthesis of cholesterol, 3) but this treatment is often accompanied by adverse reactions such as gastrointestinal tract issues, myopathy and hepatotoxicity. 4,5) Traditional Chinese Medicine (TCM) is a healthcare-focused medical system based on more than 3000 years of continuous practice experience, and therefore has its own advantages and characteristics in early intervention and personalized treatment. Some Chinese medicinal herbs have shown lipid-lowering effects by reducing the absorption of exogenous lipids and the synthesis of endogenous lipids, and also by facilitating the transportation, metabolism and excretion of lipids. 6)TCM performs multi-target network regulation based on the function of the whole body; between its characteristic good efficiency and low toxicity, TCM has received extensive attention all over the world. There are various Chinese medicinal herbs clinically prescribed to cure hyperlipidemia. Among these herbs, Polygonum multiflorum ranked as...

show abstract

A Review on the Traditional Chinese Medicinal Herbs and Formulae with Hypolipidemic Effect

Cited by 93 publications

References 177 publications

Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics

Edible Filamentous Fungi from the Species Monascus: Early Traditional Fermentations, Modern Molecular Biology, and Future Genomics

Inhibitory Potential of Terminalia chebula by Hydrogen Peroxide Induced Oxidative Stress in THP-1 Cell Line

The Anti-hyperlipidemia Effects of Raw <i>Polygonum multiflorum</i> Extract <i>in Vivo</i>

Contact Info

Product

Resources

About