The aim of this study was to evaluate the changes in physical-mechanical properties of the samples manufactured by 3D printing technology with the addition of varying degrees of polylactide (PLA) infill (50, 70, 85 and 100%). Half of the samples were soaked in physiological saline. The material used for the study was neat PLA, which was examined in terms of hydrolytic degradation, crystallization, mechanical strength, variability of properties at elevated temperatures, and dissipation of mechanical energy depending on the performed treatment. A significant impact of the amount of infill on changeable mechanical properties, such as hydrolytic degradation and crystallization was observed. The FDM printing method allows for waste–free production of light weight unit products with constant specyfic strength.