A review on Tinospora cordifolia: as an Immunomodulating agent

Abstract

Guduchi is a plant also known as Tinospora cordifolia, having heart shaped leave, an herb of the family Menispermaceae native of hot areas of the Indian subcontinent. In our classical Ayurvedic texts, it is indicated to be beneficial in treating various types of diseases like skin disorders, different types of fever, jaundice & gout. Guduchi also claimed to have various properties as an anti-oxidant, antihyperglycemic, antihyperlipidemic, hepatoprotective, cardiovascular protective, neuroprotective, osteoprotective, radioprotective, anti-anxiety, adaptogenic agent, analgesic, anti-inflammatory, antipyretic, athrombolytic agent, anti-diarrheal, anti-ulcer, antimicrobial and anti-cancer agent. Several experimental and clinical studies based on available reports, present paper is an attempt to assemble the information on immunomodulating property of Tinospora cordifolia

Quantitative and rapid quality assessment methods for the multi‐class bioactive constituents of Tinospora cordifolia using high‐performance liquid and thin layer chromatography analysis with tandem mass spectrometry characterization

“…The other samples, such as #1, #3, #6, #9-#11, #13, and #15, were lower amounts of compound (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). The 20-βhydroxy ecdysone was absent in samples #4 and #11, while tetrahydropalmatine was not detected in samples #1, #5, #10, and #15.…”

“…(Figure 3) Based on method 1, HPTLC fingerprinting of TC showed three marker compounds (7-9) from clerodane furanoditerpenes and clerodane diterpene glycoside under white light and UV 366 nm after derivatization. (Figure 3A,B) The prominent, pink-colored band (a) at retention factor (R f ) 0.77 showed the presence of compound (8) with compound (9), the dark pink band (b) at R f 0.69 and the maroon-colored band (c) at R f 0.04 for compound (7) under white light after derivatization with VSR(Figure 3A,B). Comparatively, due to lower R f, this method found less significantly suitable compound (7) in TCE.…”

“…For the simultaneous analysis, the separation of 10 compounds in the TCE was targeted and influenced by (1) polar matrix, (2) resolution of adjacent peaks,(3) shorter time (4) chemistry of targeted compounds. To achieve this, A-the sample extraction method and B-chromatographic conditions (column selection, temperature, mobile phase composition, and flow rate) were optimized [37] 1 for compounds (7)(8)(9) in method 1 (A) at white light after derivatization (B) at 366 nm after derivatization. For compounds (3)(4) in method 2 at UV 366 nm(C) before and (D) after derivatization with increasing retention factor (R f )…”

“…The reference compounds used in this study were cordifolioside A(1), syringin(2), magnoflorine(3), 20-β-hydroxy ecdysone(4), tetrahydropalmatine(5), jatrorrhizine (6), tinosporaside (7), 8-hydroxy tinosporide (8), tinosporide (9), and columbin (10). Compounds 1, 4, 7-10 were isolated from the stems of the TC in-house laboratory, and compounds 2-3, and 5-6 were procured from Chemfaces (Wuhan, Hubei, CN) (Figure 2).…”

“…Tinospora cordifolia (TC) (family Menispermaceae), commonly known as "Giloy" or "Guduchi," has been recommended in Ayurveda as a Rasayana due to its immuneboosting, detoxifying properties and promoting longevity [2]. In Ayurveda, TC is well known as Rasayana for its highest medicinal values [3][4][5][6][7][8]. The clinical results showed alleviating allergic rhinitis, sneezing, nasal obstruction, and pruritus in a randomized clinical trial over eight weeks [9,10].…”