A review on various classes of secondary metabolites and biological activities of Lamiaceae (Labiatae) (2002-2018)

Abdelaty, Nousiba A.; Attia, Eman Zekry; Hamed, Ashraf; Desoukey, Samar Yehia

doi:10.2139/ssrn.3776664

Cited by 4 publications

(5 citation statements)

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“…The studies on P. viscosa resulted in the isolation of a total 27 compounds, comprising 2 oleanan-type triterpene saponins, ▶ Table 5 Phenylethanoid glycosides grouped according to glycosidation patterns . 68) and a megastigmane glycoside: phlomuroside (101). Samioside (37) isolated from P. samia [35] was also added to the activity screenings.…”

Section: Phets (Groupsmentioning

confidence: 99%

“…In this context, a recent review article on the antimalarial active compounds from the plants of Lamiaceae underlines their potential in the search for lead compounds [100]. The potential of Lamiaceae is also emphasized by a recent review focusing on flavonoids, fatty acid derivatives, and sterols and their wide range of biological activities [101].…”

Section: Compoundsmentioning

confidence: 99%

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Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Çalış

Başer

2021

Planta Med

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As the sixth-largest Angiosperm family, Lamiaceae contains more than 245 genera and 7886 species that are distributed worldwide. It is also the third-largest family based on the number of taxa in Turkey where it is represented by 46 genera and 782 taxa with a high endemism ratio (44%). Besides, Lamiaceae are rich in plants with economic and medicinal value containing volatile and nonvolatile compounds. Many aromatic plants of Lamiaceae such as Salvia, Sideritis, Stachys, Phlomis, and Teucrium species are used in traditional herbal medicine throughout Turkey as well as in other Mediterranean countries. Salvia (Sage tea “Adaçayı”), Sideritis (Mountain tea “Dağçayı”), Stachys (Hairy Tea “Tüylü Çay”), and Phlomis (Turkish sage “Çalba or Şalba”) are the largest genera that are used as herbal teas. This review focuses on the volatile and nonvolatile compounds of Lamiaceae from the genera Phlomis and Eremostachys of the subfamily Lamioideae with emphasis on iridoids, phenylethanoid glycosides, and essential oils.

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Section: Phets (Groupsmentioning

confidence: 99%

Section: Compoundsmentioning

confidence: 99%

Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Çalış

Başer

2021

Planta Med

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“…A profusion of secondary metabolites from these species has been isolated and identified, some of them presenting pharmacological activity [ 11 , 12 , 13 , 14 , 15 ]. Antioxidant, cytotoxic, anti-inflammatory, and antimicrobial (antibacterial, antifungal, and antiviral) are examples of biological activities with potential benefits for human health [ 16 , 17 , 18 ]. Ramos da Silva et al [ 19 ]) and Correia et al [ 20 ] have emphasized the properties of Lamiaceae essential oils as antioxidants.…”

Section: Introductionmentioning

confidence: 99%

A Metabolome Analysis and the Immunity of Phlomis purpurea against Phytophthora cinnamomi

Neves

Figueiredo

Maia

et al. 2023

Plants

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Phlomis purpurea grows spontaneously in the southern Iberian Peninsula, namely in cork oak (Quercus suber) forests. In a previous transcriptome analysis, we reported on its immunity against Phytophthora cinnamomi. However, little is known about the involvement of secondary metabolites in the P. purpurea defense response. It is known, though, that root exudates are toxic to this pathogen. To understand the involvement of secondary metabolites in the defense of P. purpurea, a metabolome analysis was performed using the leaves and roots of plants challenged with the pathogen for over 72 h. The putatively identified compounds were constitutively produced. Alkaloids, fatty acids, flavonoids, glucosinolates, polyketides, prenol lipids, phenylpropanoids, sterols, and terpenoids were differentially produced in these leaves and roots along the experiment timescale. It must be emphasized that the constitutive production of taurine in leaves and its increase soon after challenging suggests its role in P. purpurea immunity against the stress imposed by the oomycete. The rapid increase in secondary metabolite production by this plant species accounts for a concerted action of multiple compounds and genes on the innate protection of Phlomis purpurea against Phytophthora cinnamomi. The combination of the metabolome with the transcriptome data previously disclosed confirms the mentioned innate immunity of this plant against a devastating pathogen. It suggests its potential as an antagonist in phytopathogens’ biological control. Its application in green forestry/agriculture is therefore possible.

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“…The species’ essential oil was found to display mosquito-repellent activity; however, the active agent for this mode of action was not yet detected [ 4 ]. The Lamiaceae family is known to harbor an interesting and valuable profile in secondary metabolites, including terpenoids, flavonoids, and phenylpropanoids [ 5 , 6 , 7 ]. These compounds play important roles in the plant’s interaction with its environment [ 8 , 9 ] as for the defense against abiotic and biotic stresses [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Differential RNA-Seq Analysis Predicts Genes Related to Terpene Tailoring in Caryopteris × clandonensis

Ritz

Ahmad

Brück

et al. 2023

Plants

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Enzymatic terpene functionalization is an essential part of plant secondary metabolite diversity. Within this, multiple terpene-modifying enzymes are required to enable the chemical diversity of volatile compounds essential in plant communication and defense. This work sheds light on the differentially transcribed genes within Caryopteris x clandonensis that are capable of functionalizing cyclic terpene scaffolds, which are the product of terpene cyclase action. The available genomic reference was subjected to further improvements to provide a comprehensive basis, where the number of contigs was minimized. RNA-Seq data of six cultivars, Dark Knight, Grand Bleu, Good as Gold, Hint of Gold, Pink Perfection, and Sunny Blue, were mapped on the reference, and their distinct transcription profile investigated. Within this data resource, we detected interesting variations and additionally genes with high and low transcript abundancies in leaves of Caryopteris x clandonensis related to terpene functionalization. As previously described, different cultivars vary in their modification of monoterpenes, especially limonene, resulting in different limonene-derived molecules. This study focuses on predicting the cytochrome p450 enzymes underlying this varied transcription pattern between investigated samples. Thus, making them a reasonable explanation for terpenoid differences between these plants. Furthermore, these data provide the basis for functional assays and the verification of putative enzyme activities.

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A review on various classes of secondary metabolites and biological activities of Lamiaceae (Labiatae) (2002-2018)

Cited by 4 publications

References 0 publications

Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

Review of Studies on Phlomis and Eremostachys Species (Lamiaceae) with Emphasis on Iridoids, Phenylethanoid Glycosides, and Essential Oils

A Metabolome Analysis and the Immunity of Phlomis purpurea against Phytophthora cinnamomi

Differential RNA-Seq Analysis Predicts Genes Related to Terpene Tailoring in Caryopteris × clandonensis

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