A review on wound healing

Visha, MG; Karunagaran, Monika

doi:10.4103/ijcpc.ijcpc_13_19

Cited by 14 publications

(2 citation statements)

References 1 publication

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“…In days 5-7 of wound healing, fibroblasts migrate into the wound, laying down new collagen of the subtypes I and III. Early in normal wound recovery, type III collagen predominates [43], supporting our morphological findings on day 7. Type III collagen is first synthesized to provide a collagenous scaffold for endothelial cells migration to form the network of capillaries typically seen in the granu- On day 7, all groups showed deposition of thin and delicate fibrils of type III collagen in a predominantly reticular pattern.…”

Section: Hydroalcoholic Extract Of V Labrusca Improves Type Iii Collagen Deposition In Day 7 Of Wound Healing But Do Not Induce Excessivesupporting

confidence: 88%

Histological Evidence of Wound Healing Improvement in Rats Treated with Oral Administration of Hydroalcoholic Extract of Vitis labrusca

Santos

Pereira-Filho

et al. 2021

CIMB

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Plant extracts rich in phenolic compounds have been demonstrated to accelerate wound healing, but their use by oral route has been poorly studied. The leaves of Vitis labrusca are rich in phenolic acids and flavonoids. The goal of this study was to assess the healing properties of the oral administration of hydroalcoholic extract of V. labrusca leaves (HEVL) in a murine model. HEVL was obtained by Soxhlet and dynamic maceration, and their yield and phenolic acids and flavonoid contents were determined. For the wound healing assay, 8 mm wounds were performed on the back of 48 Wistar rats, assigned into four groups (n = 12): CTR (distilled water), HEVL100, HEVL200, and HEVL300 (HEVL at 100, 200, and 300 mg/kg, respectively). On days 7 and 14, wound closure rates were assessed, and the healing wounds were subjected to histological analysis. Soxhlet-obtained extract was selected for the wound healing assay because it provided a higher yield and phenolic acid and flavonoid contents. HEVL significantly reduced leukocytosis in the peripheral blood (p < 0.05), accelerated wound closure (p < 0.05), and improved collagenization (p < 0.05) on day 7, as well as enhanced the epidermal tissue thickness (p < 0.001) and elastic fiber deposition on day 14 (p < 0.01). Furthermore, HEVL promoted an increase in the histological grading of wound healing on both days 7 and 14 (p < 0.01). The doses of 200 and 300 mg/kg provided better results than 100 mg/Kg. Our data provide histological evidence that the oral administration of HEVL improves wound healing in rodents. Therefore, the extract can be a potential oral medicine for healing purposes.

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Section: Hydroalcoholic Extract Of V Labrusca Improves Type Iii Collagen Deposition In Day 7 Of Wound Healing But Do Not Induce Excessivesupporting

confidence: 88%

Histological Evidence of Wound Healing Improvement in Rats Treated with Oral Administration of Hydroalcoholic Extract of Vitis labrusca

Santos

Pereira-Filho

et al. 2021

CIMB

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“…Granulation tissue is the growth of new tissue that occurs when the wound is undergoing a healing process, consisting of new capillaries and fibroblast cells that fill the cavity (Han, 2023;Shah et al, 2020). Granulation tissue formation is an important step in the proliferative and wound healing phase (Visha & Karunagaran, 2019). Granular tissue is a reddish network that contains capillaries at the base of the wound (Alhajj & Goyal, 2020).…”

Section: Introductionmentioning

confidence: 99%

Utilization of Red Fruit on The Growth of Tissue Granulation in Diabetic Wounds

Tondok,

Tafor,

Ruben

et al. 2023

jppipa, pendidikan ipa, fisika, biologi, kimia

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The utilization of red fruit on the growth of granulation tissue in diabetic wounds aims to determine the benefits of red fruit which have been scientifically proven through research in Indonesia. Methods: Conducting a literature search using the Google Scholar application and conducting an analysis of the literature included in the inclusion criteria. Results: From the search results and research results which conclude about the benefits of red fruit. Conclusion: The benefits of red fruit on the growth of granulation tissue in diabetic wounds, namely red fruit contains carotene (12,000 ppm), beta-carotene (700 ppm), tocopherol (11,000 ppm). The benefits of red fruit on the growth of granulation tissue also affect diabetic wound healing because granulation tissue is the growth of new tissue that occurs when a wound is undergoing a healing process, consisting of new capillaries and fibroblast cells that fill the cavity. Granulation tissue formation is an important step in the proliferative and healing phase of the wound. Granular tissue is a reddish network that contains capillaries at the base of the wound

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