Polymeric scaffold of Gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application

Kaparekar, Pallavi Shyam; Pathmanapan, Srinivetha; Anandasadagopan, Suresh Kumar

doi:10.1016/j.ijbiomac.2020.09.212

Cited by 60 publications

(29 citation statements)

References 70 publications

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“… Singh et al . (2019) and Kaparekar et al . (2020) have noted an improved wound contraction as well as a reduction in duration of re-epithelialization of the excision wound with the use of GA.…”

Section: Introductionmentioning

confidence: 97%

“…GA had been well demonstrated for antioxidant, analgesic, anti-inflammatory, including anti-diabetic properties. Singh et al (2019) and Kaparekar et al (2020) have noted an improved wound contraction as well as a reduction in duration of re-epithelialization of the excision wound with the use of GA. In short, all the beneficial features that GA possess to support its advancement into a practical wound recovery agent.…”

Section: Introductionmentioning

confidence: 98%

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Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Gan

Chin

2021

F1000Res

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Background: A dramatic growth in the prevalence of chronic wounds due to diabetes has represented serious global health care and economic issues. Hence, there is an imperative need to develop an effective and affordable wound dressing for chronic wounds. Recent research has featured the potential of bioactive compound gallic acid (GA) in the context of wound recovery due to their safety and comparatively low cost. However, there is a scarcity of research that focuses on formulating GA into a stable and functional hydrocolloid film dressing. Thus, this present study aimed to formulate and characterise GA-loaded alginate-based hydrocolloid film dressing which is potentially used as low to medium suppurating chronic wound treatment. Methods: The hydrocolloid composite films were pre-formulated by blending sodium alginate (SA) with different combinations of polymers. The hydrocolloid films were developed using solvent-casting method and the most satisfactory film formulation was further incorporated with various GA concentrations (0.1%, 0.5% and 1%). The drug-loaded films were then characterised for their physicochemical properties to assess their potential use as drug delivery systems for chronic wound treatment. Results: In the pre-formulation studies, sodium alginate-pectin (SA-PC) based hydrocolloid film was found to be the most satisfactory, for being homogenous and retaining smoothness on surface along with satisfactory film flexibility. The SA-PC film was chosen for further loading with GA in 0.1%, 0.5% and 1%. The characterisation studies revealed that all GA-loaded films possess superior wound dressing properties of acidic pH range (3.97-4.04), moderate viscosity (1600 mPa-s-3198 mPa-s), optimal moisture vapor transmission rate (1195 g/m2/day, 1237g/m2/day and 1112 g/m2/day), slower moisture absorption and film expansion rate and no chemical interaction between the GA and polymers under FTIR analysis. Conclusion: An SA-PC hydrocolloid film incorporated with gallic acid as a potentially applicable wound dressing for low to medium suppurating chronic wounds was successfully developed.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Gan

Chin

2021

F1000Res

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“…Prompted by the above findings, researchers have recently focused on GA formulations based on chitosan to enhance its properties and bioavailability. In this way, Kaparekar et al [ 50 ] developed a collagen-fibrin scaffold with GA-loaded chitosan nanoparticles (GA-CSNPs) to favor the sustained release of GA in the wound bed and expand its in vitro and in vivo bioavailability. Results in cell lines and experimental rats showed that the GA-CSNP scaffold increases the cell migration rate, accelerating wound contraction and shortening the epithelialization phase.…”

Section: Resultsmentioning

confidence: 99%

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Melguizo‐Rodríguez

Luna-Bertos

Ramos‐Torrecillas

et al. 2021

Foods

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The treatment of tissue damage produced by physical, chemical, or mechanical agents involves considerable direct and indirect costs to health care systems. Wound healing involves a series of molecular and cellular events aimed at repairing the defect in tissue integrity. These events can be favored by various natural agents, including the polyphenols in extra virgin olive oil (EVOO). The objective of this study was to review data on the potential effects of different phenolic compounds that can also be found in EVOO on wound healing and closure. Results of in vitro and animal studies demonstrate that polyphenols from different plant species, also present in EVOO, participate in different aspects of wound healing, accelerating this process through their anti-inflammatory, antioxidant, and antimicrobial properties and their stimulation of angiogenic activities required for granulation tissue formation and wound re-epithelialization. These results indicate the potential usefulness of EVOO phenolic compounds for wound treatment, either alone or in combination with other therapies. Human studies are warranted to verify this proposition.

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“…Table 2 illustrates the main classes of antibacterial plant constituents based on the categorization published by Cowan [ 69 ], including the representation of chemical structures of relevant examples. For instance, gallic acid (a phenolic acid), while loaded into CS-based NPs and dispersed within collagen and fibrin hydrogels [ 87 ], has shown an excellent DPPH (2,2-Diphenyl-2-picryl hydrazyl hydrate) radical scavenging activity even at the lowermost concentration of 0.05 mg/mL, strongly contributing for a faster re-epithelialization and wound contraction, qualities that are highly valued for wound dressing applications. In another study [ 88 ], thyme-essential-oil-loaded CS NPs and nanocapsules, rich in thymol and carvacrol (simple phenols), exhibited an antibacterial action dependent on thymol and carvacrol release rate, with 100% phenol release in 5 h (rather than 10 h) evoking 50% larger ZoIs, thus reinforcing their importance in the field.…”

Section: Plant-derived Biomoleculesmentioning

confidence: 99%

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

et al. 2021

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Marine-derived chitosan (CS) is a cationic polysaccharide widely studied for its bioactivity, which is mostly attached to its primary amine groups. CS is able to neutralize reactive oxygen species (ROS) from the microenvironments in which it is integrated, consequently reducing cell-induced oxidative stress. It also acts as a bacterial peripheral layer hindering nutrient intake and interacting with negatively charged outer cellular components, which lead to an increase in the cell permeability or to its lysis. Its biocompatibility, biodegradability, ease of processability (particularly in mild conditions), and chemical versatility has fueled CS study as a valuable matrix component of bioactive small-scaled organic drug-delivery systems, with current research also showcasing CS’s potential within tridimensional sponges, hydrogels and sutures, blended films, nanofiber sheets and fabric coatings. On the other hand, renewable plant-derived extracts are here emphasized, given their potential as eco-friendly radical scavengers, microbicidal agents, or alternatives to antibiotics, considering that most of the latter have induced bacterial resistance because of excessive and/or inappropriate use. Loading them into small-scaled particles potentiates a strong and sustained bioactivity, and a controlled release, using lower doses of bioactive compounds. A pH-triggered release, dependent on CS’s protonation/deprotonation of its amine groups, has been the most explored stimulus for that control. However, the use of CS derivatives, crosslinking agents, and/or additional stabilization processes is enabling slower release rates, following extract diffusion from the particle matrix, which can find major applicability in fiber-based systems within ROS-enriched microenvironments and/or spiked with microbes. Research on this is still in its infancy. Yet, the few published studies have already revealed that the composition, along with an adequate drug release rate, has an important role in controlling an existing infection, forming new tissue, and successfully closing a wound. A bioactive finishing of textiles has also been promoting high particle infiltration, superior washing durability, and biological response.

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Polymeric scaffold of Gallic acid loaded chitosan nanoparticles infused with collagen-fibrin for wound dressing application

Cited by 60 publications

References 70 publications

Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Formulation and characterisation of alginate hydrocolloid film dressing loaded with gallic acid for potential chronic wound healing

Potential Effects of Phenolic Compounds That Can Be Found in Olive Oil on Wound Healing

Bioactivity of Chitosan-Based Particles Loaded with Plant-Derived Extracts for Biomedical Applications: Emphasis on Antimicrobial Fiber-Based Systems

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