A Review: Proteomics in Nasopharyngeal Carcinoma

Abstract

Although radiotherapy is generally effective in the treatment of major nasopharyngeal carcinoma (NPC), this treatment still makes approximately 20% of patients radioresistant. Therefore, the identification of blood or biopsy biomarkers that can predict the treatment response to radioresistance and that can diagnosis early stages of NPC would be highly useful to improve this situation. Proteomics is widely used in NPC for searching biomarkers and comparing differentially expressed proteins. In this review, an overview of proteomics with different samples related to NPC and common proteomics methods was made. In conclusion, identical proteins are sorted as follows: Keratin is ranked the highest followed by such proteins as annexin, heat shock protein, 14-3-3σ, nm-23 protein, cathepsin, heterogeneous nuclear ribonucleoproteins, enolase, triosephosphate isomerase, stathmin, prohibitin, and vimentin. This ranking indicates that these proteins may be NPC-related proteins and have potential value for further studies.

Elevated expression of CD93 promotes angiogenesis and tumor growth in nasopharyngeal carcinoma

“…As is known to all, NPC is a highly metastatic head and neck cancer with high incidence and mortality rates in China and Southeast Asia [21,22]. So, it is important to understand the potential mechanism associated with NPC progression.…”

<p>Amyloid Beta (A4) Precursor Protein: A Potential Biomarker for Recurrent Nasopharyngeal Carcinoma</p>

“…With the improvement in radiotherapy techniques, about 20% of patients with NPC still have recurrence. 2 Currently, the diagnosis of rNPC relies mostly on imaging or biopsy due to lack of markers. At present, CEA is a recurrence-related biomarker for colorectal tumors.…”

MicroRNA-210 negatively regulates the radiosensitivity of nasopharyngeal carcinoma cells

“…Following radiotherapy, the five-year survival percentage for patients with NPC has increased from 50-60% to a current percentage of ~70%. However, following radical radiotherapy, ~20% of NPC patients still have residual tumors (6). Local treatment failure and distant metastasis are the key factors which prevent therapeutic efficacy, and intrinsic or acquired radiation resistance is one of the primary reasons causing the failure of radiotherapy and worse treatment outcomes (7,8).…”