A Revolutionary, Proven Solution to Vascular Access Concerns: A Review of the Advantageous Properties and Benefits of Catheter Securement Cyanoacrylate Adhesives

Abstract

Intravascular catheters are widely used among hospitals; however, their failure rates are high, up to 50%, when secured by traditional techniques, such as tape and gauze. The use of catheter securement cyanoacrylate adhesives provides a unique approach to the issues surrounding the use of traditional securement techniques for vascular access devices by providing significant securement strength, barrier properties, antibacterial properties, hemostatic properties, and flexibility. The purpose of this research was to perform a thorough and systematic review of the current literature existing regarding the use of cyanoacrylate adhesive for the care and maintenance of vascular access devices.

Effectiveness of cyanoacrylate glue in the fixation of midline catheters and peripherally inserted central catheters in hospitalised adult patients: Randomised clinical trial (CIANO-ETI)

“…Recently, in clinical practice there has been growing interest in products for the safe securement of vascular access devices (VADs) to try to decrease their associated complications. One such product is cyanoacrylate glue (CAG), 1 – 3 with octyl-butyl-cyanoacrylate (e.g. Secure-Port IV™) being one of the most commonly used types today.…”

Color changing bioadhesive barrier for peripherally inserted central catheters

“…In USA alone, more than 300 million intravascular devices are purchased every year where the total of 60% to 90% of patients require intravenous catheters during the course of hospitalization (PICC devices account for ∼200 million used annually). 14 Catheter-related blood stream infections are one of the most complicated challenges in catheter-mediated therapeutic treatments. Alarming clinical data indicates 11% of catheter-related infections that resulted in patient death during hospitalisation.…”

“…Cyanoacrylate skin adhesives have also been approved for catheter insertion site fixation and antibacterial barrier, but can be problematic to remove once applied. 14 Although clinical reports indicate the same effectiveness against catheter-related blood infections for antibiotic patches and CA formulations, there is a possible trade-off between immediate catheter sealing ( i.e. ease of application in clinical settings) and potential allergenic effect acrylate-based tapes and adhesives.…”

“…8,[11][12][13] Since initial FDA approval of cyanoacrylate (CA) skin adhesive for wound closure in 1998 (Dermabond™), numerous clinical studies have evaluated adhesive-based catheter fixation. [11][12][13][14] Results suggest adhesives decrease device failures due to blood infections and serve as an effective method for long-term vascular catheter fixation. 15 Furthermore, it was found that acrylate surfaces have an inhibitory effect on Gram positive bacteria.…”

“…17 Formaldehyde and cyanoacetate are known cytotoxic leachates. 14 Exothermic polymerization can lead to burns and diffusion of unreacted acrylate monomers. 16 The latter is a well-known cause of contact dermatitis.…”