A Risk Prediction Score for Kidney Failure or Mortality in Rhabdomyolysis

Admission Characteristics and Outcomes of ED Patients With Rhabdomyolysis

“…The independent predictors of death or AKI were age (50-70 years, 1.5 points; 71-80 years, 2.5 points; >80 years, 3 points), female sex (1 point), cause of rhabdomyolysis (origin not seizures, syncope, exercise, statins, or myositis, 3 points), and values of initial creatinine (1.4-2.2 mg/dL, 1.5 points; >2.2 mg/dL, 3 points), CK (>40.000 U/L, 2 points), phosphate (4.0-5.4 mg/dL, 1.5 points; >5.4 mg/dL, 3 points), calcium (>7.5 mg/dL, 2 points), and bicarbonate (>19 mEq/L, 2 points). Mortality rate or AKI for patients with a score under 5 was 3% and with a score over 10 was 59.2% (25). According to another recent study of 126 patients with rhabdomyolysis, the following variables on admission were independently associated with AKI; peak CK (>12.750 U/L; [odds ratio (OR), 4.9; 95% CI, 1.4-16.8]), hypoalbuminemia (<33 mg/dL; OR, 5.1; 95% CI, 1.4-17.7), metabolic acidosis (OR, 5.3; 95% CI, 1.4-20.3), and decreased PT (<82%; OR, 4.4; 95% CI, 1.3-4.5) (16).…”

“…In the United States, data from the National Hospital Discharge Survey in 1995, the main underlying cause of rhabdomyolysis is alcohol intoxication, followed by illicit drug use (24). However, in the recently larger adult study from United States conducted by McMahon et al identified 2371 patients and they found the main causative factor of rhabdomyolysis was trauma (25). In another important retrospective study from Spain performed by Rodriguez et al, the researchers examined 126 patients with severe rhabdomyolysis (defined as serum CK level > 5000 IU/L), the most frequent cause was prolonged immobilization due to consumption of illicit drugs abuse (16).…”

“…In our study, with regard to the admission phosphate levels, there was significant difference between the survivors and non-survivors groups. Recently, a large study conducted by McMahon et al showed that hyperphosphatemia was associated with increased risk of developing AKI and mortality even when it was mild degree (25). It remains unclear whether the relationship between hyperphosphatemia and adverse outcomes is causative or only associative.…”

Acute Kidney Injury with Rhabdomyolysis: 25 Years Experience from a Tertiary Care Center

“…Many large series have been published in the past, reporting relative frequencies of different etiologies [4] [5] [10]. In the present study, we report AKI secondary to rhabdomyolysis from single tertiary care center, over a period of 25 years.…”

Treningsutløst rabdomyolyse – en ny tendens?

“…Utløsende årsak, alder, kjønn og eventuelle komplikasjoner ved innleggelsen, som akutt nyresvikt med elektrolyttforstyrrelser, er viktige faktorer i vurderingen av prognosen (26).…”