A risk signature with inflammatory and immune cells infiltration predicts survival and efficiency of chemotherapy in gastric cancer

Li, Sen; Sun, Shujuan; Sun, Hongmei; Ma, Ping; Zhang, Junli; Cao, Yanghui; Liu, Chenyu; Zhang, Xijie; Wang, Wenpeng; Li, Zhiguo; Ma, Yan; Xue, Yingwei; Zhao, Yuzhou

doi:10.1016/j.intimp.2021.107589

Cited by 5 publications

(6 citation statements)

References 33 publications

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“…This study showed that the abundance of infiltrating immune cells is related to the progression and prognosis of GC. In addition, there is also evidence that immune/stromal score is an important influencing factor of GC ( 40 , 41 ). According to CIBERSORT and ESTIMATE algorithms, we predicted the abundance of infiltrating immune cells and immune/stromal score in patients with GC.…”

Section: Discussionmentioning

confidence: 99%

A novel signature based on CeRNA and immune status predicts prognostic risk and drug sensitivity in gastric cancer patients

Cao

Zhang

et al. 2022

Front. Immunol.

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BackgroundAt present, there is increasing evidence that both competitive endogenous RNAs (ceRNAs) and immune status in the tumor microenvironment (TME) can affect the progression of gastric cancer (GC), and are closely related to the prognosis of patients. However, few studies have linked the two to jointly determine the prognosis of patients with GC. This study aimed to develop a combined prognostic model based on ceRNAs and immune biomarkers.MethodsFirst, the gene expression profiles and clinical information were downloaded from TCGA and GEO databases. Then two ceRNA networks were constructed on the basis of circRNA. Afterwards, the key genes were screened by univariate Cox regression analysis and Lasso regression analysis, and the ceRNA-related prognostic model was constructed by multivariate Cox regression analysis. Next, CIBERSORT and ESTIMATE algorithms were utilized to obtain the immune cell infiltration abundance and stromal/immune score in TME. Furthermore, the correlation between ceRNAs and immunity was found out through co-expression analysis, and another immune-related prognosis model was established. Finally, combining these two models, a comprehensive prognostic model was built and visualized with a nomogram.ResultsThe (circRNA, lncRNA)-miRNA-mRNA regulatory network of GC was constructed. The predictive power of ceRNA-related and immune-related prognosis models was moderate. Co-expression analysis showed that the ceRNA network was correlated with immunity. The integrated model of combined ceRNAs and immunity in the TCGA training set, the AUC values of 1, 3, and 5-year survival rates were 0.78, 0.76, and 0.78, respectively; in the independent external validation set GSE62254, they were 0.81, 0.79, and 0.78 respectively; in GSE15459, they were 0.84, 0.88 and 0.89 respectively. Besides, the prognostic score of the comprehensive model can predict chemotherapeutic drug resistance. Moreover, we found that plasma variant translocation 1 (PVT1) and infiltrating immune cells (mast cells) are worthy of further investigation as independent prognostic factors.ConclusionsTwo ceRNA regulatory networks were constructed based on circRNA. At the same time, a comprehensive prognosis model was established, which has a high clinical significance for prognosis prediction and chemotherapy drug selection of GC patients.

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Section: Discussionmentioning

confidence: 99%

A novel signature based on CeRNA and immune status predicts prognostic risk and drug sensitivity in gastric cancer patients

Cao

Zhang

et al. 2022

Front. Immunol.

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“… 291 The number of PD‐L1 + neutrophils and CD66b + neutrophils are associated with the survival of GC patients. 292 , 293 , 294 Interestingly, the number of FasL + PD‐L2 + neutrophils was reported to be associated with poor prognosis of GC in another study. These neutrophils owned immunosuppressive functions on tumor‐specific CD8 + T cells and promoted the growth and progression of human GC tumors both in vitro and in vivo.…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 93%

“…This suggested that neutrophil subsets might drive metastatic in specific tumor sites 291 . The number of PD‐L1 + neutrophils and CD66b + neutrophils are associated with the survival of GC patients 292–294 . Interestingly, the number of FasL + PD‐L2 + neutrophils was reported to be associated with poor prognosis of GC in another study.…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 97%

“…Targeting tumor‐associated CXCR2 + neutrophils and CCR2 + macrophages was reported to improve chemotherapeutic responses in pancreatic ductal adenocarcinoma 342 . In a nutshell, a series of studies have shown that it is necessary to investigate neutrophil heterogeneity in the context of pancreatic cancer treatment 266–343 . For subsequent investigation, the inductive factors of the emergence of diverse neutrophil subsets may be probed, enabling a brand‐new viewpoint for the treatment of pancreatic cancer.…”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

“… 342 In a nutshell, a series of studies have shown that it is necessary to investigate neutrophil heterogeneity in the context of pancreatic cancer treatment. 266 , 267 , 268 , 269 , 270 , 271 , 272 , 273 , 274 , 275 , 276 , 277 , 278 , 279 , 280 , 281 , 282 , 283 , 284 , 285 , 286 , 287 , 288 , 289 , 290 , 291 , 292 , 293 , 294 , 295 , 296 , 297 , 298 , 299 , 300 , 301 , 302 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , …”

Section: Neutrophil Heterogeneity In Diseasesmentioning

confidence: 99%

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The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Zhou

Cao

et al. 2023

MedComm

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Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high‐resolution viewpoint. A growing body of evidence has confirmed the double‐edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil‐related diseases.

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Exosomal miRNAs from neutrophils act as accurate biomarkers for gastric cancer diagnosis

Yu,

Zhang,

Wang

et al. 2024

Clinica Chimica Acta

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A risk signature with inflammatory and immune cells infiltration predicts survival and efficiency of chemotherapy in gastric cancer

Cited by 5 publications

References 33 publications

A novel signature based on CeRNA and immune status predicts prognostic risk and drug sensitivity in gastric cancer patients

A novel signature based on CeRNA and immune status predicts prognostic risk and drug sensitivity in gastric cancer patients

The double‐edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Exosomal miRNAs from neutrophils act as accurate biomarkers for gastric cancer diagnosis

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