A roadmap of strategies to support cardiovascular researchers: from policy to practice

Chapman, Niamh; Thomas, Emma; Tan, Joanne; Inglis, Sally C.; Wu, Jason; Climie, Rachel E.; Picone, Dean; Blekkenhorst, Lauren C.; Wise, Steven G.; Colafella, Katrina M Mirabito; Calkin, Anna C.; Marques, Francine Z.

doi:10.1038/s41569-022-00700-1

Cited by 9 publications

(2 citation statements)

References 66 publications

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“…As displayed, virtually all conditions show a sex-driven disparity or a gender bias for injuries, but two conditions are of paramount importance when dealing with sex differences: cardiovascular diseases (CVDs) and neurological disorders. This is particularly true considering that CVDs are a leading cause of death, whereas neurological disorders strongly impact the quality of life of affected patients [ 5 , 6 ]. For these reasons, such conditions are constantly studied from a prevention and treatment point of view, and accumulating evidence suggests that both share an underlying sex difference [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-Related Differences of Matrix Metalloproteinases (MMPs): New Perspectives for These Biomarkers in Cardiovascular and Neurological Diseases

Trentini

Manfrinato

Castellazzi

et al. 2022

JPM

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It is now established that sex differences occur in clinical manifestation, disease progression, and prognosis for both cardiovascular (CVDs) and central nervous system (CNS) disorders. As such, a great deal of effort is now being put into understanding these differences and turning them into “advantages”: (a) for the discovery of new sex-specific biomarkers and (b) through a review of old biomarkers from the perspective of the “newly” discovered sex/gender medicine. This is also true for matrix metalloproteinases (MMPs), enzymes involved in extracellular matrix (ECM) remodelling, which play a role in both CVDs and CNS disorders. However, most of the studies conducted up to now relegated sex to a mere confounding variable used for statistical model correction rather than a determining factor that can influence MMP levels and, in turn, disease prognosis. Consistently, this approach causes a loss of information that might help clinicians in identifying novel patterns and improve the applicability of MMPs in clinical practice by providing sex-specific threshold values. In this scenario, the current review aims to gather the available knowledge on sex-related differences in MMPs levels in CVDs and CNS conditions, hoping to shed light on their use as sex-specific biomarkers of disease prognosis or progression.

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Section: Introductionmentioning

confidence: 99%

Sex-Related Differences of Matrix Metalloproteinases (MMPs): New Perspectives for These Biomarkers in Cardiovascular and Neurological Diseases

Trentini

Manfrinato

Castellazzi

et al. 2022

JPM

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show abstract

“…(2019); Vos et al (2020). However, the field of CVD research is currently confronted with inadequate funding and a shortage of researchers, particularly women, who are leaving the field (Chapman et al, 2022;Nicholls, 2018). To facilitate a comprehensive analysis of CVD-related data, we have collected a database of NIH-funded heart disease research publications and related information spanning the period from 2002 to 2020.…”

Section: Introductionmentioning

confidence: 99%

Gender Gap and Impact Analysis in Cardiovascular Research

Rozenshteyn,

Homayouni

2023

Preprint

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The objective of this study is to assess gender inequalities in research publications in the field of heart disease and to examine the influence of these disparities on research success. Our approach employs explainable machine learning models to gauge publication impact, uncovering the key institutional and demographic factors contributing to successful research outcomes, measured by the beneficiaries of the published research. We analyze a database of heart disease research publications funded by the National Institutes of Health (NIH) from 2002 to 2020. Our analysis uncovers gender disparities, particularly a greater presence of male first authors in prominent journals and institutions. Furthermore, works authored by males generally garner more citations and achieve higher NIH funding scores than those by females, highlighting an enduring gender disparity in publication rates and visibility. In conclusion, this study offers crucial insights into the determinants of impactful publications in the field of heart disease research, encompassing institutional affiliations, gender inequalities, journal rankings, and study types.

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An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15

et al. 2023

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A roadmap of strategies to support cardiovascular researchers: from policy to practice

Cited by 9 publications

References 66 publications

Sex-Related Differences of Matrix Metalloproteinases (MMPs): New Perspectives for These Biomarkers in Cardiovascular and Neurological Diseases

Sex-Related Differences of Matrix Metalloproteinases (MMPs): New Perspectives for These Biomarkers in Cardiovascular and Neurological Diseases

Gender Gap and Impact Analysis in Cardiovascular Research

An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15

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