Under conditions of consumer panic buying, satisfying demand with the available products is a complex problem. In reality, most retailers accept alternative products during panic situations. This study considers the case of firm-driven substitution of products (differing in weight) based on retailer preferences over two time-periods. In the proposed model, panic behavior emerged in the first time-period and interruption in supply occurred in the second time-period. Under this model, retail stores were segmented into high index (valuable) and low index (less valuable) customers. Before meeting the demand of low-index customers, wholesalers attempt to satiate high-index customer's panic buying behavior. To generate maximum wholesaler's total profit, we find the optimal amount of substitution quantity, quantity to order, and leftover units. The model is investigated for both without and with substitution. To gain managerial insights, we also examined the influence of both the degree of interruption in supply and substitution costs on profits and decisions. The results can assist business managers to improve the decision-making process.