A Role for Endothelin in Neuropathic Pain After Chronic Constriction Injury of the Sciatic Nerve

Klass, Markus; Hord, Allen H.; Wilcox, Melissa M.; Denson, Don; Csete, Marie

doi:10.1213/01.ane.0000180766.74782.7e

Cited by 32 publications

(25 citation statements)

References 48 publications

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“…1998a), injected subcutaneously into the plantar surface of the hind paw, (Baamonde et al 2004;Balonov et al 2006;Gokin et al 2001;Houck et al 2004;Menendez et al 2003b;Piovezan et al 1998Piovezan et al , 2004Verri et al 2004Verri et al , 2005 or skin of the back (Mujenda et al 2007), and injected into tumor-bearing tissues Schmidt et al 2007;Wacnik et al 2001). In contrast, the newer ET A receptor-selective antagonists have been administered systemically (Chichorro et al 2006a;Klass et al 2005;Matwyshyn et al 2006;Piovezan et al 2000;Trentin et al 2006). Because we were interested in the role of ET A receptors near the tumor, presumably on the terminals of C nociceptors, we chose BQ-123 as the ET A receptor-selective antagonist as it has been shown to be effective when injected into peripheral tissues.…”

Section: Discussionmentioning

confidence: 99%

“…For example, systemic administration of an ET A receptor-selective antagonist attenuated mechanical allodynia in the streptozotocin-induced diabetic rat model of neuropathic pain (Jarvis et al 2000) and heat and mechanical hyperalgesia produced by chronic constriction injury of the sciatic nerve (Klass et al 2005). However, a similar constriction injury to the infraorbital nerve produced mechanical allodynia that was attenuated by systemic administration of an ET B receptor-selective antagonist (Chichorro et al 2006a).…”

Section: Role Of Et-1 In Inflammatory Neuropathic and Tumor-evoked mentioning

confidence: 99%

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Tumor-Evoked Sensitization of C Nociceptors: A Role for Endothelin

Hamamoto

Khasabov

Cain

et al. 2008

Journal of Neurophysiology

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Hamamoto DT, Khasabov SG, Cain DM, Simone DA. Tumorevoked sensitization of C nonciceptos: a role for endothelin. J Neurophysiol 100: 2300 -2311, 2008. First published August 6, 2008 doi:10.1152/jn.01337.2007. Primary and metastatic cancers that effect bone are frequently associated with pain. Sensitization of primary afferent C nociceptors innervating tissue near the tumor likely contributes to the chronic pain and hyperalgesia accompanying this condition. This study focused on the role of the endogenous peptide endothelin-1 (ET-1) as a potential peripheral algogen implicated in the process of cancer pain. Electrophysiological response properties, including ongoing activity and responses evoked by heat stimuli, of C nociceptors were recorded in vivo from the tibial nerve in anesthetized control mice and mice exhibiting mechanical hyperalgesia following implantation of fibrosarcoma cells into and around the calcaneus bone. ET-1 (100 M) injected into the receptive fields of C nociceptors innervating the plantar surface of the hind paw evoked an increase in ongoing activity in both control and tumor-bearing mice. Moreover, the selective ET A receptor antagonist, BQ-123 (3 mM), attenuated tumor-evoked ongoing activity in tumor-bearing mice. Whereas ET-1 produced sensitization of C nociceptors to heat stimuli in control mice, C nociceptors in tumor-bearing mice were sensitized to heat, and their responses were not further increased by ET-1. Importantly, administration of BQ-123 attenuated tumor-evoked sensitization of C nociceptors to heat. We conclude that ET-1 at the tumor site contributes to tumor-evoked excitation and sensitization of C nociceptors through an ET A receptor mediated mechanism.

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Section: Discussionmentioning

confidence: 99%

Section: Role Of Et-1 In Inflammatory Neuropathic and Tumor-evoked mentioning

confidence: 99%

Tumor-Evoked Sensitization of C Nociceptors: A Role for Endothelin

Hamamoto

Khasabov

Cain

et al. 2008

Journal of Neurophysiology

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“…In mice with neuropathic pain after chronic constriction injury of the sciatic nerve Klass et al [16] found that endothelin was a mediator of pain in general. They suggest that their results motivate studies of endothelin as a potential novel therapy for neuropathic pain.…”

Section: Immune Markers and Neuropeptidesmentioning

confidence: 99%

Stress biomarkers' associations to pain in the neck, shoulder and back in healthy media workers: 12-month prospective follow-up

et al. 2007

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Physiological and psychological mechanisms have been proposed to link stress and musculoskeletal pain (MSP), and a number of stress biomarkers in patients with chronic pain have shown to be associated with stress-related disorders as well as health and recovery. The aim was to study if similar results might be found in a working population, in stress and computer intensive occupations with mild/moderate pain in neck, shoulder and back. The questions were if there are: (1) associations between self rated neck, shoulder and back pain (VAS) on one hand and stress-related (catabolic), recovery related (anabolic) variables, cardiovascular/lifestyle factors and immune markers on the other hand. (2) associations between long term changes in pain and stress marker values (6 month period). (3) predictive values in stress biomarkers for pain (12 month period) A study group with 121 media workers, 67 males (average 45 years) and 53 females (average 43 years), at three news departments of a media company was recruited. Pain occurrence and pain level in neck, shoulder, upper and low back were self-rated at three times with a 6-month interval towards the last month. Stress biomarker sampling was performed, at the same intervals. An additional similar questionnaire with momentary ratings focusing on ''at present'' i.e. within the same hour as stress biomarker sampling was performed. There were no changes in medicine intake or computer working hours during the 12 month study period. The total pain level and prevalence of pain decreased between baseline and 12 monthś follow-up. The rate of participation was 95%. Cross-sectional analyses on differences in stress biomarkers in groups of ''no pain'' and ''pain'' showed less beneficial stress biomarker levels (P \ 0.05) in the ''pain'' group after age and gender adjustments in: S-DHEA-S and P-endothelin, S-insulin and P-fibrinogen. Analyses of each gender separately, adjusted for age, revealed in males differences in S-insulin, saliva cortisol 3, and P-endothelin. Furthermore, tendencies were seen in BMI, P-fibrinogen, and S-testosterone. In the female ''pain'' group a less beneficial P-BNP level was found. Longitudinal analysis of changes in pain levels and stress biomarkers within an interval of 6 months showed beneficial changes in the following stress markers: P-NPY, S-albumin, S-growth hormone and S-HDL when pain decreased, and vice versa when pain increased. Linear regression analyses showed statistically significant predicting values at the initial test instance for pain 12 months later in lower S-DHEA-S and S-albumin and higher B-HbA1c and P-fibrinogen. In stepwise regression and after age and gender adjustments, the associations with S-DHEA-S remained statistically significant. The present study shows that individuals in working life with a high level of regenerative/anabolic activity have less pain than other subjects, and that decreased regenerative/anabolic activity is associated with increasing pain. The levels of NPY, albumin, GH and HDL increased when pain de...

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“…in a diabetic rat model of neuropathic pain [15,18]. Intravenous ET-B, but not ET-A, receptor antagonist reduces mechanical allodynia in rats with trigeminal neuropathic pain [3].…”

Section: Discussionmentioning

confidence: 99%

“…whereas local or systemic ET-receptor antagonists attenuate a variety of nociceptive states [1,3,7,11,15,[18][19][20]26]. However, little is known about the role of ET receptors found in the spinal cord in nociception [23].…”

Section: Introductionmentioning

confidence: 99%