A role for the cortex in sleep–wake regulation

Krone, Lukas B.; Yamagata, Tomoko; Blanco‐Duque, Cristina; Guillaumin, Mathilde C. C.; Kahn, Martin; Vinne, Vincent van der; McKillop, Laura E; Tam, Shu K. E.; Peirson, Stuart N.; Akerman, Colin J.; Hoerder‐Suabedissen, Anna; Molnár, Zoltán; Vyazovskiy, Vladyslav V.

doi:10.1038/s41593-021-00894-6

Cited by 102 publications

(87 citation statements)

References 49 publications

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“…There is little reason to expect that the cortical signatures of the sleeping donor would entrain subcortical structures (such as the SCN or VLPO) of the recipient. Nevertheless, recent research confirms that cortical structures play a role in regulating sleep homeostasis and global sleep-wake dynamics (Krone et al, 2021), leaving room for the possibility that the state of sleep may be induced by entrainment, as suggested here.…”

Section: Brain Waves As Neural Correlates Of Brain Statessupporting

confidence: 52%

Replicating Cortical Signatures May Open the Possibility for “Transplanting” Brain States via Brain Entrainment

Poltorak

2021

Front. Hum. Neurosci.

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Brain states, which correlate with specific motor, cognitive, and emotional states, may be monitored with noninvasive techniques such as electroencephalography (EEG) and magnetoencephalography (MEG) that measure macroscopic cortical activity manifested as oscillatory network dynamics. These rhythmic cortical signatures provide insight into the neuronal activity used to identify pathological cortical function in numerous neurological and psychiatric conditions. Sensory and transcranial stimulation, entraining the brain with specific brain rhythms, can effectively induce desired brain states (such as state of sleep or state of attention) correlated with such cortical rhythms. Because brain states have distinct neural correlates, it may be possible to induce a desired brain state by replicating these neural correlates through stimulation. To do so, we propose recording brain waves from a “donor” in a particular brain state using EEG/MEG to extract cortical signatures of the brain state. These cortical signatures would then be inverted and used to entrain the brain of a “recipient” via sensory or transcranial stimulation. We propose that brain states may thus be transferred between people by acquiring an associated cortical signature from a donor, which, following processing, may be applied to a recipient through sensory or transcranial stimulation. This technique may provide a novel and effective neuromodulation approach to the noninvasive, non-pharmacological treatment of a variety of psychiatric and neurological disorders for which current treatments are mostly limited to pharmacotherapeutic interventions.

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Section: Brain Waves As Neural Correlates Of Brain Statessupporting

confidence: 52%

Replicating Cortical Signatures May Open the Possibility for “Transplanting” Brain States via Brain Entrainment

Poltorak

2021

Front. Hum. Neurosci.

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“… 23 The frontal dominance reflects the increased sensitivity of the EEG derived from this cortical region to perturbations of sleep homeostasis relative to more posterior regions. 14 , 38 , 39 Moreover, all participants in the present study performed in-laboratory tests using visual modalities, lasting approximately 20 min, five times during each shift. Visual tests actively engage the occipital cortex, and the EEG responses may also be a result of local, use-dependent sleep homeostatic processes induced by cognitive workload and visual neural processing during the shift.…”

Section: Discussionmentioning

confidence: 99%

“…For instance, the synaptosomal-associated Protein, 25 kDa (SNAP-25) serves both as a driver of circadian rhythmicity 50 and a regulator of sleep-dependent slow wave activity. 38 A question to be asked is whether the sleep homeostatic response remains or reaches a peak level after three night shifts, and if this is regulated by an allostatic process (at the level of cellular physiology, sleep EEG and/or other physiological responses) when facing additional sleep loss.…”

Section: Discussionmentioning

confidence: 99%

Sleep Homeostasis and Night Work: A Polysomnographic Study of Daytime Sleep Following Three Consecutive Simulated Night Shifts

Pedersen¹,

Sunde²,

Wisor³

et al. 2022

NSS

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Purpose Millions of people work at times that overlap with the habitual time for sleep. Consequently, sleep often occurs during the day. Daytime sleep is, however, characterized by reduced sleep duration. Despite preserved time spent in deep NREM sleep (stage N3), daytime sleep is subjectively rated as less restorative. Knowledge on how night work influences homeostatic sleep pressure is limited. Therefore, we aimed to explore the effect of three consecutive simulated night shifts on daytime sleep and markers of sleep homeostasis. Patients and Methods We performed continuous EEG, EMG and EOG recordings in the subjects’ home setting for one nighttime sleep opportunity, and for the daytime sleep opportunities following three consecutive simulated night shifts. Results For all daytime sleep opportunities, total sleep time was reduced compared to nighttime sleep. While time spent in stage N3 was preserved, sleep pressure at sleep onset, measured by slow wave activity (1–4 Hz), was higher than nighttime sleep and higher on day 3 than on day 1 and 2. Elevated EEG power during daytime sleep was sustained through 6 h of time in bed. Slow wave energy was not significantly different from nighttime sleep after 6 h, reflecting a less efficient relief of sleep pressure. Conclusion Adaptation to daytime sleep following three consecutive simulated night shifts is limited. The increased homeostatic response and continuation of sleep pressure relief even after 6 h of sleep, are assumed to reflect a challenge for appropriate homeostatic reduction to occur.

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“…Previous studies have shown that autonomous activity and sleep-wake rhythm are regulated by the nervous system (Mišić et al, 2016;Oikonomou et al, 2019;Jackson et al, 2020;Krone et al, 2021) and Hp infection might directly or indirectly affect the nervous system via the microbiome-gut-brain axis (Gorlé et al, 2021). Vacuolating cytotoxin A (VacA) is a major cytotoxin produced by Hp in the stomach (Cover et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice

Liu

Zheng²,

Zhang

et al. 2022

Front. Pharmacol.

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Many reports have shown that patients with Hp-associated chronic gastritis exhibit anxiety and poor sleep quality. However, less is known about the effects and specific manifestations of Hp-associated chronic gastritis on autonomous activity and sleep quality in animals. Here, we investigated the effect of Helicobacter pylori (Hp)-associated chronic gastritis on autonomous activity and sleep quality in mice. To do this, a Hp-associated chronic gastritis mouse model was first established, then analyzed for autonomous activity, relative to controls, for 15 min using an autonomous activity tester. Next, sleep quality of mice was detected by sodium pentobarbital-induced sleep experiment and results compared between groups. The results showed that male mice in the model group exhibited higher activity counts but lower forelimb lift counts, relative to those in the control group, although there were no significant differences (all p > .05). Conversely, female mice in the model group recorded lower activity counts, albeit at no significant difference (p > .05), and significantly lower counts of forelimb lift (p < .05), relative to those in the control group. Notably, male mice in the model group had longer sleep latency and shorter sleep duration than those in the control group, albeit at no significant differences (all p > .05). On the other hand, female mice in the model group recorded significantly longer sleep latency as well as shorter sleep duration compared to those in the control group (all p < .01). We conclude that Hp-associated chronic gastritis exerts certain effects on autonomous activity and sleep quality of mice in a gender-dependent manner. Notably, female mice with Hp-associated chronic gastritis had lower activity and forelimb lift counts, as well as prolonged sleep latency, and shortened sleep duration. These effects were all statistically significant except for activity counts.

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A role for the cortex in sleep–wake regulation

Cited by 102 publications

References 49 publications

Replicating Cortical Signatures May Open the Possibility for “Transplanting” Brain States via Brain Entrainment

Replicating Cortical Signatures May Open the Possibility for “Transplanting” Brain States via Brain Entrainment

Sleep Homeostasis and Night Work: A Polysomnographic Study of Daytime Sleep Following Three Consecutive Simulated Night Shifts

Effect of Helicobacter pylori-Associated Chronic Gastritis on Autonomous Activity and Sleep Quality in Mice

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