A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats

Capriles, Nancy; Rodaros, Demetra; Sorge, Robert E.; Stewart, Jane

doi:10.1007/s00213-002-1283-z

Cited by 373 publications

(324 citation statements)

References 30 publications

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“…This work has shown that the circuitry involved in mediating reinstatement induced by footshock overlaps substantially with that involved in mediating reinstatement induced by drug-associated cues and by drug priming (Shaham et al, 2003). Thus, regions such as the VTA, the PFC and the nucleus accumbens are all part of the circuitry involved in these different types of reinstatement (Bossert et al, 2006Capriles et al, 2003;Fuchs et al, 2005;McFarland et al, 2004;McFarland and Kalivas, 2001). Local infusion of a D1 receptor antagonist into the PFC blocked footshockinduced reinstatement suggesting that such reinstatement could result from enhanced dopaminergic activity in the PFC (Capriles et al, 2003).…”

Section: Discussionmentioning

confidence: 93%

“…Thus, regions such as the VTA, the PFC and the nucleus accumbens are all part of the circuitry involved in these different types of reinstatement (Bossert et al, 2006Capriles et al, 2003;Fuchs et al, 2005;McFarland et al, 2004;McFarland and Kalivas, 2001). Local infusion of a D1 receptor antagonist into the PFC blocked footshockinduced reinstatement suggesting that such reinstatement could result from enhanced dopaminergic activity in the PFC (Capriles et al, 2003). Yohimbine activates a number of brain regions that are also activated by footshock, including the nucleus accumbens, the VTA and the PFC (Funk et al, 2006;Singewald et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

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The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues

Fletcher

Rizos

Sinyard

et al. 2007

Neuropsychopharmacol

112

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Previously, we showed that the 5-HT 2C receptor agonist Ro60-0175 reduces cocaine self-administration, and the ability of cocaine to reinstate responding after extinction of drug-seeking behavior. The present experiments extended these findings further by determining whether the effects of Ro60-0175 on self-administration were sustained with repeated treatment, and whether Ro60-0175 altered reinstatement induced by the pharmacological stressor yohimbine, or by the context in which self-administration occurred. In Experiment 1, Ro60-0175 (1 mg/kg, s.c.) reduced cocaine (0.25 mg/infusion) self-administration maintained by a progressive ratio schedule. This reduction was sustained over eight daily injections. In Experiment 2, rats self-administered cocaine in daily 2 h sessions for 15 days on a FR1 schedule. Following extinction, yohimbine (1 mg/kg, i.p.) reinstated responding, and this effect was reduced dose dependently by Ro60-0175 (0.3-3 mg/kg, s.c.). In Experiment 3, rats were trained to respond for cocaine on a FR1 schedule in a distinct environmental context (A); responding was then extinguished in a different context (B). Reinstatement tests occurred in either context A or B.Responding was reinstated only when rats were tested in the original self-administration context (A). This reinstatement was reduced dose dependently by Ro60-0175. All effects of Ro60-0175 were blocked by the 5-HT 2C receptor antagonist SB242084. Thus, Ro60-0175, acting via 5-HT 2C receptors, reduces cocaine self-administration and cocaine-seeking triggered by a stressor and by drug-associated cues. The effects of Ro60-0175 do not exhibit tolerance within the 8-day test period. These results indicate that selective 5-HT 2C receptor agonists may be a useful pharmacological strategy for treatment of drug abuse.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues

Fletcher

Rizos

Sinyard

et al. 2007

Neuropsychopharmacol

112

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“…In these studies, physical stress (foot shock) given for various periods of time reinstated rat leverpressing for ethanol (Liu and Weiss 2003;Martin-Fardon et al 2000), cocaine (Capriles et al 2003;Lu et al 2001), heroin (Leri et al 2004;Shaham and Stewart 1996;Zhou et al 2008), and morphine (Mueller et al 2002). Also, immobilization stress given within the place preference chamber is capable of producing reinstatement of cocaine-seeking behavior in male Sprague-Dawley rats (Sanchez et al 2003).…”

Section: Consequences Of Csc On Body Weight Gain and Anxiety-like Behmentioning

confidence: 99%

Chronic psychosocial stress causes delayed extinction and exacerbates reinstatement of ethanol-induced conditioned place preference in mice

Bahí

Dreyer

2013

Psychopharmacology

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Rationale We have shown previously, using an animal model of voluntary ethanol intake and ethanol-conditioned place preference (EtOH-CPP), that exposure to chronic psychosocial stress induces increased ethanol intake and EtOH-CPP acquisition in mice. Objective Here, we examined the impact of chronic subordinate colony (CSC) exposure on EtOH-CPP extinction, as well as ethanol-induced reinstatement of CPP. Methods Mice were conditioned with saline or 1.5 g/kg ethanol and were tested in the EtOH-CPP model. In the first experiment, the mice were subjected to 19 days of chronic stress, and EtOH-CPP extinction was assessed during seven daily trials without ethanol injection. In the second experiment and after the EtOH-CPP test, the mice were subjected to 7 days of extinction trials before the 19 days of chronic stress. Druginduced EtOH-CPP reinstatement was induced by a priming injection of 0.5 g/kg ethanol. Results Compared to the single-housed colony mice, CSC mice exhibited increased anxiety-like behavior in the elevated plus maze (EPM) and the open field tests. Interestingly, the CSC mice showed delayed EtOH-CPP extinction. More importantly, CSC mice showed increased alcohol-induced reinstatement of the EtOH-CPP behavior. Conclusion Taken together, this study indicates that chronic psychosocial stress can have long-term effects on EtOH-CPP extinction as well as drug-induced reinstatement behavior and may provide a suitable model to study the latent effects of chronic psychosocial stress on extinction and relapse to drug abuse.

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“…Imaging studies of cocaine addicts show that both cocaine and cocaine-paired cues increase metabolic activity in this circuit (Maas et al, 1998;Kilts et al, 2001;Grant et al, 1996;Breiter et al, 1997;Childress et al, 1999). Preclinical studies based on reinstatement models also point to the important role of this circuit in cocaine-seeking behavior (McFarland and Kalivas, 2001;Capriles et al, 2003;McLaughlin and See, 2003). In fact, preclinical evidence has identified specific receptor mechanisms by which various components of the mesocorticolimbic circuit control behavioral responses to cocaine.…”

Section: Introductionmentioning

confidence: 99%

Ionotropic Glutamate Receptors in the Ventral Tegmental Area Regulate Cocaine-Seeking Behavior in Rats

Sun

Akins

Mattingly

et al. 2005

Neuropsychopharmacol

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Drug addiction is characterized by compulsive drug-seeking and drug-taking behavior and by a high rate of relapse even after long periods of abstinence. Although the mesocorticolimbic dopamine (DA) pathway is thought to play a critical role in drug craving and relapse, recent evidence also implicates glutamate, an amino acid known to activate DA neurons in the ventral tegmental area (VTA) via ionotropic receptors. To assess whether increased glutamate transmission in the VTA is involved in cocaine-primed drug-seeking behavior, we tested rats in a between-session reinstatement model. They were trained to press a lever for cocaine infusions (0.25 mg/ infusion) accompanied by compound stimuli (light and tone) under a modified fixed-ratio 5 reinforcement schedule. Cocaine-primed reinstatement was conducted after lever pressing was extinguished in the absence of the conditioned stimuli. Blockade of ionotropic glutamate receptors in the VTA by local application of kynurenate (0.0, 1.0, 3.2, and 5.6 mg/side) dose-dependently decreased cocaineprimed reinstatement, whereas sucrose-primed reinstatement of sucrose-seeking behavior was unaffected. In addition, the minimum effective dose for decreasing cocaine-primed reinstatement was ineffective in the substantia nigra. Together, these data indicate that glutamatergic activation of the VTA is critical for cocaine-primed reinstatement. Because such activation can increase impulse flow in DA neurons and thus DA release in mesocorticolimbic targets, this glutamate-DA interaction in the VTA may underlie cocaine-primed relapse to cocaine-seeking behavior.

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A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats

Abstract: These results suggest that the PL and OFC regions form part of the circuitry mediating the effects of foot shock stress on reinstatement of drug seeking and that the PL region may be a common pathway for cue, drug and foot-shock stress-induced reinstatement of drug seeking.

Cited by 373 publications

References 30 publications

The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues

The 5-HT2C Receptor Agonist Ro60-0175 Reduces Cocaine Self-Administration and Reinstatement Induced by the Stressor Yohimbine, and Contextual Cues

Chronic psychosocial stress causes delayed extinction and exacerbates reinstatement of ethanol-induced conditioned place preference in mice

Ionotropic Glutamate Receptors in the Ventral Tegmental Area Regulate Cocaine-Seeking Behavior in Rats

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