A Role for the Respiratory Chain in Regulating Meiosis Initiation in <i>Saccharomyces cerevisiae</i>

Zhao, Haichao; Wang, Qian; Liu, Chao; Shang, Yun; Wen, Fuping; Wang, Fang; Liu, Weixiao; Xiao, Wei; Li, Wei

doi:10.1534/genetics.118.300689

Cited by 22 publications

(19 citation statements)

References 52 publications

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“…In addition to trehalose and glycogen metabolism, our previous study also identified mitochondrial biomass as an excellent predictor for meiosis (Arguello‐Miranda et al, ). These results were consistent with the essential requirement of functional mitochondria for meiosis (Zhao et al, ). Cells with dysfunctional mitochondria, known as “petite,” or with defects in oxidative ATP production are unable to sporulate (Jambhekar & Amon, ).…”

Section: Introductionsupporting

confidence: 91%

Functional interrelationships between carbohydrate and lipid storage, and mitochondrial activity during sporulation in Saccharomyces cerevisiae

Liu

Wood

Marchand

et al. 2020

Yeast

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In Saccharomyces cerevisiae under conditions of nutrient stress, meiosis precedes the formation of spores. Although the molecular mechanisms that regulate meiosis, such as meiotic recombination and nuclear divisions, have been extensively studied, the metabolic factors that determine the efficiency of sporulation are less understood. Here, we have directly assessed the relationship between metabolic stores and sporulation in S. cerevisiae by genetically disrupting the synthetic pathways for the carbohydrate stores, glycogen (gsy1/2Δ cells), trehalose (tps1Δ cells), or both (gsy1/2Δ and tps1Δ cells). We show that storage carbohydrate‐deficient strains are highly inefficient in sporulation. Although glycogen and trehalose stores can partially compensate for each other, they have differential effects on sporulation rate and spore number. Interestingly, deletion of the G1 cyclin, CLN3, which resulted in an increase in cell size, mitochondria and lipid stores, partially rescued meiosis progression and spore ascus formation but not spore number in storage carbohydrate‐deficient strains. Sporulation efficiency in the carbohydrate‐deficient strain exhibited a greater dependency on mitochondrial activity and lipid stores than wild‐type yeast. Taken together, our results provide new insights into the complex crosstalk between metabolic factors that support gametogenesis.

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Section: Introductionsupporting

confidence: 91%

Functional interrelationships between carbohydrate and lipid storage, and mitochondrial activity during sporulation in Saccharomyces cerevisiae

Liu

Wood

Marchand

et al. 2020

Yeast

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“…Sporulation requires respiration 73,74 . Relaxed selection on sporulation may therefore indirectly lower the selection also for respiration, and this could partially account for the worse respiratory growth in domesticated lineages.…”

Section: Discussionmentioning

confidence: 99%

Domestication reprogrammed the budding yeast life cycle

Chiara

Barré

Persson

et al. 2020

Preprint

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Domestication of plants and animals is the foundation for feeding the worldpopulation. We report that domestication of the model yeast S. cerevisiae reprogrammed its life cycle entirely. We tracked growth, gamete formation and cell survival across many environments for nearly 1000 genome sequenced isolates and found a remarkable dichotomy between domesticated and wild yeasts. Wild yeasts near uniformly trigger meiosis and sporulate when encountering nutrient depletions, whereas domestication relaxed selection on sexual reproduction and favoured survival as quiescent cells. Domestication also systematically enhanced fermentative over respiratory traits while decreasing stress tolerance. We show that this yeast domestication syndrome was driven by aneuploidies and gene function losses that emerged independently in multiple domesticated lineages during the specie's recent evolutionary history. We found domestication to be the most dramatic event in budding yeast evolution, raising questions on how much domestication has distorted our understanding of this key model species.

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“…A nonautonomous feedback loop requires an extracellular signal, and one candidate signal for the Rim101-Ime1 loop is alkaline pH. For example, sporulating colonies increase the pH of their environment (Hayashi et al 1998; Piccirillo et al 2010; Zhao et al 2018), and alkaline pH is the primary stimulus for the Rim101/AR pathway. To determine whether increased pH drives the Rim101-Ime1 positive-feedback loop, we performed two types of experiments.…”

Section: Resultsmentioning

confidence: 99%

How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies

et al. 2019

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A Role for the Respiratory Chain in Regulating Meiosis Initiation in Saccharomyces cerevisiae

Abstract: 23Meiosis is a specific type of cell division that is essential for sexual reproduction in most

Cited by 22 publications

References 52 publications

Functional interrelationships between carbohydrate and lipid storage, and mitochondrial activity during sporulation in Saccharomyces cerevisiae

Functional interrelationships between carbohydrate and lipid storage, and mitochondrial activity during sporulation in Saccharomyces cerevisiae

Domestication reprogrammed the budding yeast life cycle

How Boundaries Form: Linked Nonautonomous Feedback Loops Regulate Pattern Formation in Yeast Colonies

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