A role of peptidergic nerves in the internal anal sphincter of Hirschsprung's disease

Tomita, Ryouichi; Morita, Ken; Tanjoh, Katsuhisa; Munakata, Keimei

doi:10.1016/s0039-6060(99)70289-8

Cited by 12 publications

(5 citation statements)

References 27 publications

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“…SP is released from intestinal nerves to stimulate acetylcholine release from other intestinal nerves, and for production of rhythmic contraction in the intestinal smooth muscle [13]. A possible role has also been suggested for SPcontaining nerves in the effector control of the internal anal sphincter and its dysfunction [14]. SP is a member of the tachykinin family of peptides and its effects are mediated through the stimulation of tachykinin NK1, NK2 and NK3 receptors, preferentially by the NK1 receptor [15].…”

Section: Introductionmentioning

confidence: 99%

Age-related changes in substance P-immunoreactive nerve structures of the rat recto-anal region

et al. 2010

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AbstractThe recto-anal region is innervated by extrinsic and intrinsic nerves and a number of neuropeptides including substance P (SP) have been suggested to participate in the regulation of intestinal movements. We examined the age-related changes in the distribution of SP-immunoreactive nerve structures in the distal part of the rat large intestine. Using immunohistochemistry, the presence of SP was studied in fresh tissues from Wistar rats at different ages taken at three sampling sites, the distal rectum, anal canal and internal anal sphincter. In the 15-day old rats the myenteric plexus of the distal rectum and anal canal was well outlined by numerous SP-immunoreactive varicose nerve fibres encircling immunonegative perikarya. In the circular muscle layer, nerve fibres and small nerve bundles ran parallel to the muscle cells, while in the longitudinal muscle layer, only occasional nerve fibres were seen. At the level of the internal anal sphincter, no myenteric ganglia were present. Here, thin varicose fibers ran parallel to the smooth muscle cells. In the 3-month old rats, a larger number of intensely staining SP-immunoreactive nerve fibres were found and in the circular muscle layer, thicker nerve strands were observed. In the 26-month old rats, the density and staining intensity of SP-immunopositive nerve fibres in the myenteric plexus was lower than in the 3-month-old rats. Similar changes in the SP-immunostained fibres in the internal anal sphincter were observed. Degenerative alterations in SP-containing fibres during aging appear to play a role in ano-rectal motility and sphincter control.

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Section: Introductionmentioning

confidence: 99%

Age-related changes in substance P-immunoreactive nerve structures of the rat recto-anal region

et al. 2010

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“…The mechanism of intestinal movement is complicated in humans, and its control probably involves the delicate functioning of the nervous systems (central, peripheral, intestinal wall nerves), the immune system (gastrointestinal hormones and cytokines), and other factors such as carbon monoxide [18][19][20][21][22], and studies from various perspectives are therefore required.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Jejunal Interdigestive Migrating Motor Complex and Quality of Life after Total Gastrectomy with Roux‐en‐Y Reconstruction for Early Gastric Cancer

et al. 2003

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A total of 22 patients (16 men, 6 women; age 33 to 70 years, m mean, 60.2 years) 1.0 to 1.5 years (mean 1 year and 2 months) after total gastrectomy with Roux‐en‐Y reconstruction for early gastric cancer (D2 lymph node dissection, curability A) were divided into two groups based on the occurrence of interdigestive migrating motor complex, phase III (IMMC‐pIII) from the Roux‐en‐Y loop, and postoperative quality of life (QOL) was compared. Results were as follows: (1) Patients in the IMMC‐ pIII positive group (n = 12) had more appetite and ate more food with less decrease in body weight than those in the IMMC‐pIII negative group (n = 10). (2) Patients in the IMMC‐pIII positive group clearly had fewer symptoms, such as early dumping symptoms (systemic symptoms), symptoms of reflux esophagitis (e.g., heartburn, feeling of regurgitation, difficult swallowing), nausea, abdominal pain, diarrhea, abdominal fullness, and borborygmus, than those in the IMMC‐pIII negative group. These results showed a more satisfactory condition in regard to abdominal symptoms in the IMMC‐pIII positive group than in the IMMC‐pIII negative group.

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“…13,14 하지만 최근에 와서는 비아 드레날린성 비콜린성(nonadrenergic noncholinergic, NANC) 신경계가 장관운동의 조절에 중요한 역할을 함이 알려졌으며 정상 대장에서 장관운동의 조절에 NANC 흥분성 신경보다 NANC 억제성 신경이 주도적 인 역할을 한다고 알려졌다. [15][16][17]…”

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The Effect of Autonomic Nerve System on Neurotensin Induced Motility in Isolated, Vascularly Perfused Rat Colon

Kim

Seo

et al. 2010

Intest Res

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Background/Aims: Although neurotensin (NT) stimulates colon motility and the passage of intestinal contents, the associated mechanism of action remains unclear. The objective of this study was to investigate the effects of NT on colon motility using isolated rat colon. Methods: Intraluminal pressure was measured at both the proximal and distal portions of the isolated colon. An isolated rat colon was perfused with Krebs solution via the superior mesenteric artery. After stabilization, NT was administered in concentrations of 14, 28, 138 and 276 pM. After pretreatment with phentolamine, propranolol, hexamethonium, atropine or tetrodotoxin, NT was administered at a concentration of 276 pM, and then the intraluminal pressure was monitored. Results: NT significantly increased colon motility at concentrations of 14, 28, 138, and 276 in the proximal colon (25.1±6.5%, 175.4±117.0%, 240.8±115.1% and 252.3±110.6%, respectively) and in the distal colon (35.6±11.8%, 97.5±35.1%, 132.7±36.7% and 212.1±75.2%, respectively). The stimulant effect of NT was more potent in the proximal colon, in a concentration-dependent manner (P＜0.05). The stimulant effect of NT was significantly inhibited by atropine at both the proximal and distal colon and by tetrodotoxin at the proximal colon, but not by tetrodotoxin at the distal colon and not by propranolol, phentolamine, or hexamethonium at both the proximal and distal colon. Conclusions: NT increased colon motility at both the proximal and distal portions of the rat colon. The effects were more prominent at the proximal portion. The results of this study suggest that the stimulant action of NT may be mediated by local cholinergic muscarinic receptors.

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A role of peptidergic nerves in the internal anal sphincter of Hirschsprung's disease

Cited by 12 publications

References 27 publications

Age-related changes in substance P-immunoreactive nerve structures of the rat recto-anal region

Age-related changes in substance P-immunoreactive nerve structures of the rat recto-anal region

Relationship between Jejunal Interdigestive Migrating Motor Complex and Quality of Life after Total Gastrectomy with Roux‐en‐Y Reconstruction for Early Gastric Cancer

The Effect of Autonomic Nerve System on Neurotensin Induced Motility in Isolated, Vascularly Perfused Rat Colon

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