A ROS-scavenging hydrogel loaded with bacterial quorum sensing inhibitor hyperbranched poly-L-lysine promotes the wound scar-free healing of infected skin in vivo

Stimuli-responsive therapeutic systems for the treatment of diabetic infected wounds

“…Recently, it has been found that the hydrogel with adjustable bioactive activity has a good application prospect in the removal of pathogens and biofilms. 111,112 For example, a magnetite iron oxide (Fe 3 O 4 )/chitin gel nanocomposite was designed for biofilm eradication (Fig. 8A).…”

Targeted Anti-Biofilm Therapy: Dissecting Targets in the Biofilm Life Cycle

“…In addition, accessory gene regulator ( agr ) is the most classic QS system of S. aureus [ 113 ]. Xu et al verified that hyperbranched poly-L-lysine (HBPL) inhibited QS mediated by the agr system and inhibited expression of QS-related genes ( Figure 5 b) [ 114 ]. Luteolin, as a QSI, also inhibited downregulation of agrA gene, but whether it has a targeted effect needs further study [ 115 ].…”

In Situ Cross-Linked Collagen-Based Biological Patch Integrating Anti-Infection and Anti-Calcification Properties

“…27 In addition, biocompatibility and antimicrobial activity are sometimes contradictory, such as that excessive use of silver and other metal nano antibacterial agents can adversely affect the biocompatibility of the material. 32 Quaternary ammonium compounds have broad-spectrum antibacterial properties, but quaternary ammonium salts present in the free state are more toxic. If antimicrobial quaternary ammonium groups are organically incorporated into the material, the material can have long-lasting antimicrobial properties without destroying biocompatibility.…”

“…In order to prevent infection after the patch is implanted or when the biological patch is used in complex or contaminated abdominal wall defect repair and other application scenarios, , the biological patch should have certain antimicrobial properties. For improving the antimicrobial properties of biomaterials, researchers have taken several methods, such as depositing metal nanoparticles with antibacterial activity on the material, , adding natural plant essential oils, loading bacterial inhibitors, or loading photothermal conversion particles for photothermal therapy of antimicrobial activity. , However, the use of antibiotics can lead to the development of bacterial resistance and even superbugs . In addition, biocompatibility and antimicrobial activity are sometimes contradictory, such as that excessive use of silver and other metal nano antibacterial agents can adversely affect the biocompatibility of the material .…”

“…For improving the antimicrobial properties of biomaterials, researchers have taken several methods, such as depositing metal nanoparticles with antibacterial activity on the material, , adding natural plant essential oils, loading bacterial inhibitors, or loading photothermal conversion particles for photothermal therapy of antimicrobial activity. , However, the use of antibiotics can lead to the development of bacterial resistance and even superbugs . In addition, biocompatibility and antimicrobial activity are sometimes contradictory, such as that excessive use of silver and other metal nano antibacterial agents can adversely affect the biocompatibility of the material . Quaternary ammonium compounds have broad-spectrum antibacterial properties, but quaternary ammonium salts present in the free state are more toxic.…”