A Salmon Thrombin-Fibrin Bandage Controls Arterial Bleeding in a Swine Aortotomy Model

Abstract

Fibrin dressing using salmon-derived thrombin and fibrinogen is effective in controlling severe, uncontrolled bleeding. This dressing may offer an alternative to dressings composed of human coagulation proteins.

Stability, sterility, coagulation, and immunologic studies of salmon coagulation proteins with potential use for mammalian wound healing and cell engineering

“…Our results demonstrate that a salmon-derived fibrinogen and thrombin complex preparation does not cause disturbances in peripheral blood coagulation in experimental animals. Together with previous studies demonstrating efficacy of salmon fibrin as a hemostatic agent [15], these data motivate further work to test the suitability of salmonderived coagulation proteins for clinical applications.…”

“…Recent studies show that salmon-derived thrombin and fibrinogen are biologically equivalent to proteins used in existing FG [12][13][14] and can be used instead of bovine-derived materials. In several animal models including swine aortotomy [15], salmon FG performed either equal to or better than commercially available glues derived from mammalian proteins. Pilot experiments on guinea pigs reveal that the thrombin/ fibrinogen complex derived from salmon blood does not cause a biological reaction after a one time administration.…”

In Pursuit of Functional Electrospun Materials for Clinical Applications in Humans

“…For example, SURGICLOT ® developed by St. Teresa Medical, Inc. ® (NCT02509208) is being evaluated as a hemostatic dressing that uses electrospun dextran fibers to deliver 10 In pursuit of functional electrospun materials for clinical applications Review thrombin and fibrinogen proteins to promote blood clotting at a surgical or wound site [15,16]. A transdermal patch comprised four layers of electrospun polyurethane fibers and designed to release nitric oxide (NO) delivered as bound nitrite on polysulfonate beads has been evaluated in two different Phase III, doubleblind clinical trials [17][18][19].…”

The potential for salmon fibrin and thrombin to mitigate pain subsequent to cervical nerve root injury

“…Further, salmon fibrin clots readily at temperatures as low as 0°C, while human fibrinogen activated by thrombin clots slowly below 23°C [33]; this difference provides an advantage in situations where hypothermia must be used. A swine aortotomy model demonstrated salmon fibrin dressing to be effective in controlling severe bleeding [34]. Although there is an increased focus on the use of salmon-derived blood products for repair and tissue healing, few studies have investigated these materials for repair of neuronal tissue or for their potential to alleviate pain.…”