A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice

Diao, Pan; Wang, Xiaojing; Jia, Fangping; Kimura, Takefumi; Hu, Xiao; Shirotori, Saki; Nakamura, Ibuki; Sato, Yoshiko; Nakayama, Jun; Moriya, Kyoji; Koike, Kazuhiko; Gonzalez, Frank J.; Aoyama, Toshifumi

doi:10.1016/j.jnutbio.2020.108460

Cited by 13 publications

(23 citation statements)

References 45 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The comparative densitometric analysis of protein spots included liver samples isolated from 32 mice fed a 3-month diet consisted of a set of 510 spots that occurred on each of 2DE gels. The values of each spot's intensity in the four groups in two technical replications for individuals were used to analyze the multiple regression function recorded in the form of a model (1). The same model (1) was used to analyze biochemical and relative expression levels of selected target genes.…”

Section: Discussionmentioning

confidence: 99%

“…Significant differences between means were determined using the statistical model (1). Results were considered significant at AB -p < 0.05; CD -p < 0.01; EF -p < 0.001 and highlighted in bold.…”

Section: Analysis Of Liver Proteome Differencesmentioning

confidence: 99%

“…Saturated fatty acids (SFAs) are mainly found in dairy foods, lards, processed meats—e.g., salami, sausage and bacon—manufactured foods—including snacks, cakes and biscuits—and deep-fried foods. Plant-derived oils like palm and coconut oils are also sources of SFAs [ 1 ]. In recent years, interest in coconut oil consumption has increased.…”

Section: Introductionmentioning

confidence: 99%

“…A positive correlation was also found between the plasma PUFA/SFA and HDL-c/LDL-c ratios (r = +66, p < 0.01) in the group of patients with type 2 diabetes mellitus (T2DM) and hypertension [ 12 ]. Additionally, female mortality caused by breast cancer was the highest in the group characterized by high saturated fat intake [ 1 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

et al. 2021

View full text Add to dashboard Cite

The aim of the study was to evaluate the effect of different types of high-fat diets (HFDs) on the proteomic profile of mouse liver. The analysis included four dietary groups of mice fed a standard diet (STD group), a high-fat diet rich in SFAs (SFA group), and high-fat diets dominated by PUFAs with linoleic acid (LA, C18:2n–6) to α-linolenic acid (ALA, C18:3n–3) ratios of 14:1 (14:1 group) and 5:1 (5:1 group). After three months of diets, liver proteins were resolved by two-dimensional gel electrophoresis (2DE) using 17 cm non-linear 3–10 pH gradient strips. Protein spots with different expression were identified by MALDI-TOF/TOF. The expression of 13 liver proteins was changed in the SFA group compared to the STD group (↓: ALB, APOA1, IVD, MAT1A, OAT and PHB; ↑: ALDH1L1, UniProtKB—Q91V76, GALK1, GPD1, HMGCS2, KHK and TKFC). Eleven proteins with altered expression were recorded in the 14:1 group compared to the SFA group (↓: ARG1, FTL1, GPD1, HGD, HMGCS2 and MAT1A; ↑: APOA1, CA3, GLO1, HDHD3 and IVD). The expression of 11 proteins was altered in the 5:1 group compared to the SFA group (↓: ATP5F1B, FTL1, GALK1, HGD, HSPA9, HSPD1, PC and TKFC; ↑: ACAT2, CA3 and GSTP1). High-PUFA diets significantly affected the expression of proteins involved in, e.g., carbohydrate metabolism, and had varying effects on plasma total cholesterol and glucose levels. The outcomes of this study revealed crucial liver proteins affected by different high-fat diets.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Analysis Of Liver Proteome Differencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In the same study, the results also demonstrated that excessive SFA intake stimulated TLR4 and inflammasome signaling, leading to the persistent activation of NF‐κB signaling. More than that, long‐term SFA‐rich diet intake promoted JNK/AP‐1 signaling and the overexpression of cyclin D1 and p62, which result in liver tumorigenesis (Diao et al., 2020). Previous epidemiological studies have also suggested that higher consumption of SFAs can lead to the development of breast and rectal cancer (Xia, Ma, Wang, & Sun, 2015).…”

Section: Application Of Different Lipids In Cancer Malnutritionmentioning

confidence: 99%

New perspective toward nutritional support for malnourished cancer patients: Role of lipids

Wang

Zhang

Liu

et al. 2021

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

To improve the difficulties related to malnutrition, nutritional support has become an essential part of multidisciplinary comprehensive treatment for cancer. Lipids are essential nutrient source for the human body, and nowadays in clinical practices, it has a positive interventional effect on patients suffering from cancer. However, contribution of lipids in nutritional support of cancer patients is still poorly understood. Moreover, the sensory and physicochemical properties of lipids can severely restrict their applications in lipid‐rich formula foods. In this review article, for the first time, we have presented a summary of the existing studies which were related to the associations between different lipids and improved malnutrition in cancer patients and discussed possible mechanisms. Subsequently, we discussed the challenges and effective solutions during processing of lipids into formula foods. Further, by considering existing problems in current lipid nutritional support, we proposed a novel method for the treatment of malnutrition, including developing individualized lipid nutrition for different patients depending on the individual's genotype and enterotype. Nonetheless, this review study provides a new direction for future research on nutritional support and the development of lipid‐rich formula foods for cancer patients, and probably will help to improve the efficacy of lipids in the treatment of cancer malnutrition.

show abstract

Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice

et al. 2021

View full text Add to dashboard Cite

A saturated fatty acid-rich diet enhances hepatic lipogenesis and tumorigenesis in HCV core gene transgenic mice

Cited by 13 publications

References 45 publications

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

Effects of Three-Month Administration of High-Saturated Fat Diet and High-Polyunsaturated Fat Diets with Different Linoleic Acid (LA, C18:2n–6) to α-Linolenic Acid (ALA, C18:3n–3) Ratio on the Mouse Liver Proteome

New perspective toward nutritional support for malnourished cancer patients: Role of lipids

Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice

Contact Info

Product

Resources

About