A Schiff base hydrogel dressing loading extracts from Periplaneta Americana for diabetic wound healing

Guo, Fengbiao; Liu, Yang; Chen, Shengqin; Lin, Yukai; Yue, Yan

doi:10.1016/j.ijbiomac.2023.123256

Cited by 14 publications

(5 citation statements)

References 45 publications

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“…In a skin wound model of diabetic mice, the hydrogel bio-adhesive not only down-regulated inflammation but also promoted neovascularization and proregenerative macrophage activation. Oxidized HA (OHA), which inherits the fascinating physical and chemical properties of HA, has also been recruited to design hydrogel bio-adhesives [125]. In a study by Han et al, OHA was cross-linked with CMCS via Schiff base reaction to form a biocompatible and biodegradable hydrogel bio-adhesive (CMCS-OHA) for hemostasis [92].…”

Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

“…Its linear sugar chain is composed of (1-4) β-D-mannuronic acid (M) and (1-4) α-L-guluronic acid (G) repeating units [127,128]. The Oxidized HA (OHA), which inherits the fascinating physical and chemical properties of HA, has also been recruited to design hydrogel bio-adhesives [125]. In a study by Han et al, OHA was cross-linked with CMCS via Schiff base reaction to form a biocompatible and biodegradable hydrogel bio-adhesive (CMCS-OHA) for hemostasis [92].…”

Section: Alginatementioning

confidence: 99%

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Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Yang

Wang

2023

Gels

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Wound healing is a long-term and complex biological process that involves multiple hemostasis, inflammation, proliferation, and remodeling stages. In order to realize comprehensive and systematic wound management, appropriate wound treatment bio-adhesives are urgently needed. Hydrogel bio-adhesives have excellent properties and show unique and remarkable advantages in the field of wound management. This review begins with a detailed description of the design criteria and functionalities of ideal hydrogel bio-adhesives for wound healing. Then, recent advances in polysaccharide-based multifunctional hydrogel bio-adhesives, which involve chitosan, hyaluronic acid, alginate, cellulose, dextran, konjac glucomannan, chondroitin sulfate, and other polysaccharides, are comprehensively discussed. Finally, the current challenges and future research directions of polysaccharide-based hydrogel bio-adhesives for wound healing are proposed to stimulate further exploration by researchers.

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Section: Hyaluronic Acid (Ha)mentioning

confidence: 99%

Section: Alginatementioning

confidence: 99%

Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Yang

Wang

2023

Gels

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“…31 In addition, hydrogels developed by Schiff-base reactions can form reversible carbon−nitrogen double bonds through dynamic covalent bond reactions between aldehyde groups and amino groups. 32 Once the carbon−nitrogen double bonds in the hydrogel network structure are broken, the amino groups or aldehyde groups at the broken site can quickly and spontaneously react with the surrounding aldehyde groups or amino groups to reform new carbon−nitrogen double bond structures 33 and therefore endow the hydrogels with injectable, self-healing functions. 34 Additionally, wound healing is often accompanied by bacterial infection, and the most effective ways to tackle infection in clinical practices are antibiotic employment or bioactive molecules incorporated into the wound dressing.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, hydrogels with three-dimensional network porous structure, superior biocompatibility, and extracellular matrix-like microenvironment have attracted much attention and have been favored by many researchers. − Hydrogels possess significant advantages in absorbing large amounts of tissue exudates, moisturizing and cooling wounds, relieving pain, and promoting wound healing. − Moreover, hydrogels with antibacterial and bactericidal properties and injectable and self-healing capabilities are more suitable for the treatment of infected wounds because these types of hydrogels can not only promptly remove bacteria from infected wounds, eliminate wound inflammation, and reduce dressing change frequency, but they are also suitable for treatment of irregular wounds, promote and accelerate the healing of infected wounds, and have therefore been highly favored . In addition, hydrogels developed by Schiff-base reactions can form reversible carbon–nitrogen double bonds through dynamic covalent bond reactions between aldehyde groups and amino groups . Once the carbon–nitrogen double bonds in the hydrogel network structure are broken, the amino groups or aldehyde groups at the broken site can quickly and spontaneously react with the surrounding aldehyde groups or amino groups to reform new carbon–nitrogen double bond structures and therefore endow the hydrogels with injectable, self-healing functions …”

Section: Introductionmentioning

confidence: 99%

Turning Polysaccharides into Injectable and Rapid Self-Healing Antibacterial Hydrogels for Antibacterial Treatment and Bacterial-Infected Wound Healing

Gao,

Deng,

et al. 2024

Langmuir

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Great efforts have been devoted to the development of novel and multifunctional wound dressing materials to meet the different needs of wound healing. Herein, we covalently grafted quaternary ammonium groups (QAGs) containing 12-carbon straight-chain alkanes to the dextran polymer skeleton. We then oxidized the resulting product into oxidized quaternized dextran (OQD). The obtained OQD polymer is rich in antibacterial QAGs and aldehyde groups. It can react with glycol chitosan (GC) via the Schiff-base reaction to form a multifunctional GC@OQD hydrogel with good self-healing behavior, hemostasis, injectability, inherent superior antibacterial activity, biocompatibility, and excellent promotion of healing of methicillin-resistant Staphylococcus aureus (MRSA)-infected wounds. The biosafe and nontoxic GC@OQD hydrogel with a three-dimensional porous network structure possesses an excellent swelling rate and water retention capacity. It can be used for hemostasis and treating irregular wounds. The designed GC@OQD hydrogel with inherent antibacterial activity possesses good antibacterial efficacy on both S. aureus (Gram-positive bacteria) and Escherichia coli (Gram-negative bacteria), as well as MRSA bacteria, with antibacterial activity greater than 99%. It can be used for the treatment of wounds infected by MRSA and significantly promotes the healing of wounds. Thus, the multifunctional antibacterial GC@OQD hydrogel has the potential to be applied in clinical practice as a wound dressing.

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“… 14 , 29 , 30 Yue et al developed a CMCS-based hydrogel dressing loaded with active peptides that can effectively promote the healing of diabetic wounds. 31 However, CMCS hydrogels have inherently poor antimicrobial properties and lack long-lasting active ingredients (active ingredients such as peptides are prone to inactivation) to promote tissue repair, which limits their use in skin repair. Tannic acid (TA) is a naturally occurring organic compound found in plants.…”

Section: Introductionmentioning

confidence: 99%

A TA/Cu2+ Nanoparticle Enhanced Carboxymethyl Chitosan-Based Hydrogel Dressing with Antioxidant Properties and Promoting Wound Healing

Huang,

Chen,

Cheng

et al. 2024

IJN

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Background As the first line of immune defense and the largest organ of body, skin is vulnerable to damage caused by surgery, burns, collisions and other factors. Wound healing in the skin is a long and complex physiological process that is influenced by a number of different factors. Proper wound care can greatly improve the speed of wound healing and reduce the generation of scars. However, traditional wound dressings (bandages, gauze, etc.) often used in clinical practice have a single function, lack of active ingredients and are limited in use. Hydrogels with three-dimensional network structure are a potential biomedical material because of their physical and chemical environment similar to extracellular matrix. In particular, hydrogel dressings with low price, good biocompatibility, degradability, antibacterial and angiogenic activity are favored by the public. Methods Here, a carboxymethyl chitosan-based hydrogel dressing (CMCS-TA/Cu 2+ ) reinforced by copper ion crosslinked tannic acid (TA/Cu 2+ ) nanoparticles was developed. This study investigated the physical and chemical characteristics, cytotoxicity, and angiogenesis of TA/Cu 2+ nanoparticles and CMCS-TA/Cu 2+ hydrogels. Furthermore, a full-thickness skin defect wound model was employed to assess the in vivo wound healing capacity of hydrogel dressings. Results The introduction of TA/Cu 2+ nanoparticles not only could increase the mechanical properties of the hydrogel but also continuously releases copper ions to promote cell migration (the cell migration could reach 92% at 48 h) and tubule formation, remove free radicals and promote wound healing (repair rate could reach 90% at 9 days). Conclusion Experiments have proved that CMCS-TA/Cu 2+ hydrogel has good cytocompatibility, antioxidant and wound healing ability, providing an advantageous solution for skin repair.

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A Schiff base hydrogel dressing loading extracts from Periplaneta Americana for diabetic wound healing

Cited by 14 publications

References 45 publications

Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Polysaccharide-Based Multifunctional Hydrogel Bio-Adhesives for Wound Healing: A Review

Turning Polysaccharides into Injectable and Rapid Self-Healing Antibacterial Hydrogels for Antibacterial Treatment and Bacterial-Infected Wound Healing

A TA/Cu2+ Nanoparticle Enhanced Carboxymethyl Chitosan-Based Hydrogel Dressing with Antioxidant Properties and Promoting Wound Healing

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