A scoping review of African natural products against gastric ulcers and Helicobacter pylori

Dinat, S.; Orchard, Ané; Vuuren, Sandy van

doi:10.1016/j.jep.2022.115698

Cited by 19 publications

(7 citation statements)

References 147 publications

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“…Several natural products with anti- H. pylori properties are found in the scientific literature, such as Aloe vera [ 12 ], Syzygium aromaticum [ 13 ], Canarium album Raeusch. [ 14 ], essential oils and South African honey [ 15 ]. Due to the scientific interest in finding therapeutic alternatives in natural products to control and combat the infection of H. pylori , and the good results found, it is promising to look for new products that have not yet been studied that may present this property.…”

Section: Introductionmentioning

confidence: 99%

Brazilian Red Propolis Presents Promising Anti-H. pylori Activity in In Vitro and In Vivo Assays with the Ability to Modulate the Immune Response

et al. 2022

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Helicobacter pylori is a Gram-negative, microaerophilic, curved-rod, flagellated bacterium commonly found in the stomach mucosa and associated with different gastrointestinal diseases. With high levels of prevalence worldwide, it has developed resistance to the antibiotics used in its therapy. Brazilian red propolis has been studied due to its biological properties, and in the literature, it has shown promising antibacterial activities. The aim of this study was to evaluate anti-H. pylori from the crude hydroalcoholic extract of Brazilian red propolis (CHEBRP). For this, in vitro determination of the minimum inhibitory and bactericidal concentration (MIC/MBC) and synergistic activity and in vivo, microbiological, and histopathological analyses using Wistar rats were carried out using CHEBRP against H. pylori strains (ATCC 46523 and clinical isolate). CHEBRP presented MIC/MBC of 50 and 100 μg/mL against H. pylori strains (ATCC 43526 and clinical isolate, respectively) and tetracycline MIC/MBC of 0.74 µg/mL. The association of CHEBRP with tetracycline had an indifferent effect. In the stomach mucosa of rats, all treatments performed significantly decreased the number of H. pylori, and a concentration of 300 mg/kg was able to modulate the inflammatory response in the tissue. Therefore, CHEBRP showed promising anti-H. pylori in in vitro and in vivo assays.

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Section: Introductionmentioning

confidence: 99%

Brazilian Red Propolis Presents Promising Anti-H. pylori Activity in In Vitro and In Vivo Assays with the Ability to Modulate the Immune Response

et al. 2022

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“…Across the globe, extensive research has delved into the antiulcer potential of various traditional medicinal herbs 79,80,81 . One such herbal remedy B. ciliata has gained attention for its reported efficacy in addressing stomach disorders and gastric ulcers 82,83 because of its traditional usage in the treatment of stomach disorder.…”

Section: Antiulcer Activitymentioning

confidence: 99%

Bridging Tradition and Modern Pharmacology of Bergenia ciliata (Haw.) Sternb: A Review

Rai,

Rai

2024

J. Drug Delivery Ther.

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Bergenia ciliata, a perennial rhizomatous herb holds a special place in the traditional herbal healthcare system due to its diverse therapeutic uses and potentials. Validation of its efficacy with scientific investigation is a prerequisite of any prospective herbal resource. The plant is a rich source of various bioactive chemical compounds. The present review is an attempt to consolidates comprehensive information sourced from 100 different literatures, exploring the plant's distribution, phytochemistry, traditional medicinal uses, and pharmacological activities specially focusing on some prevalent diseases of present day. The herb’s antimicrobial, anticancer, antiulcer and antidiabetic properties signify its potential in modern pharmacology. The review underscores B. ciliata's relevance in drug development and nutraceutical formulations, bridging age-old wisdom with contemporary healthcare solutions. Further exploration into its bioactive compounds and clinical applications promises innovative avenues in therapeutic intervention. Keywords: Bergenia ciliata, perennial rhizomatous herb, traditional herbal healthcare, age-old wisdom

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Section: Introductionmentioning

confidence: 99%

“…It has been reported that many natural products derived from medicinal plants, with broad and varied biological activities, as well as good efficacy and safety characteristics, have been used as anti-ulcer treatments to provide more choice for patients. 8 Berberine (BBR) is an alkaloid component of Scutellaria baicalensis Georgi, Phellodendron amurense Rupr, and Coptis chinensis Franch, that has excellent anti-bacterial and anti-diarrheal effects with few side effects. 9,10 According to the literature, BBR exerts anti-gastric ulcer activity by modulating H + /K + -ATPase activity and the dynamic balance of pro-oxidant and antioxidant systems.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism

Guo,

Lu,

Zhang

et al. 2024

JIR

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Background and Objective Peptic ulcer is a high incidence gastrointestinal disease in China. Berberine (BBR) is a natural product isolated from the Chinese herb Coptis chinensis Franch that has protective effects in digestive diseases. We aimed to evaluate the ability of BBR to attenuate acute gastric ulcer induced by one-time administration of ethanol in the rat. Methods Tissue pathological morphology, macroscopic score, ulcer healing rate, and serum levels of the inflammatory cytokines nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), and anti-inflammatory interleukin-10 (IL-10) were used to determine the efficacy of BBR and evaluated to identify the optimal dosage. Subsequently, transcriptome and metabolome sequencing were conducted in Control, Model, and optimal dosage groups to explore the pathogenesis of the disease and the mechanism of action of the drug. The levels of malondialdehyde (MDA), myeloperoxidase (MPO), as well as those of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were determined by enzyme-linked immunosorbent assay to verify the results of transcriptomics and metabolomics analyses. Results BBR significantly improved the pathological morphology of gastric ulcers, increased the macroscopic score and healing rate, decreased serum levels of NO, IL-6, and PGE2, and increased serum levels of IL-10, thus effectively alleviating gastric ulcer severity. Transcriptome results showed that the therapeutic effect of BBR was mainly mediated by the arachidonic acid metabolism pathway at the gene level, which is closely associated with inflammation and increased levels of reactive oxygen species (ROS). The differentially accumulated metabolite prostaglandin E1, which is a negative regulator of ROS, was significantly up-regulated after BBR administration. The validation results indicated that BBR pretreatment increased SOD and GSH-Px enzyme activities, while reducing levels of the oxidative products MDA and MPO. Conclusion This study demonstrated that BBR exerts a protective effect on acute gastric ulcer by promoting tricarboxylic acid cycle-mediated arachidonic acid metabolism.

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A scoping review of African natural products against gastric ulcers and Helicobacter pylori

Cited by 19 publications

References 147 publications

Brazilian Red Propolis Presents Promising Anti-H. pylori Activity in In Vitro and In Vivo Assays with the Ability to Modulate the Immune Response

Brazilian Red Propolis Presents Promising Anti-H. pylori Activity in In Vitro and In Vivo Assays with the Ability to Modulate the Immune Response

Bridging Tradition and Modern Pharmacology of Bergenia ciliata (Haw.) Sternb: A Review

Protective Effect of Berberine on Acute Gastric Ulcer by Promotion of Tricarboxylic Acid Cycle-Mediated Arachidonic Acid Metabolism

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