A Scoping Review of the Use of Silver-impregnated Dressings for the Treatment of Chronic Wounds

Rodriguez-Arguello, Jimena; Lienhard, Karin; Patel, Pooja P.; Geransar, Rose; Somayaji, Ranjani; Parsons, Laurie; Conly, John; Ho, Chester

doi:10.25270/owm.2018.3.1431

Cited by 22 publications

(28 citation statements)

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“…Chronic wounds are a term used to encompass all wounds that fail to heal within 12 weeks and can include, but are not limited to, diabetic foot ulcers, pressure sores, and venous leg ulcers ( Rodriguez-Arguello et al, 2018 ). Chronic wounds often remain recalcitrant due to their diverse microbial communities ( Gardner et al, 2013 ; Kalan et al, 2016 ), which can profoundly affect clinical outcome ( Baldan et al, 2014 ; Wolcott et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

“…Silver (Ag) and silver nanoparticles (AgNPs) exhibit potent antimicrobial efficacy against a range of bacterial species ( Ruparelia et al, 2008 ), including antibiotic-resistant strains ( Mekkawy et al, 2017 ; Tiwari et al, 2017a , b ) and established biofilms ( Ueno et al, 2016 ) in experimental settings. In the clinic, the evidence for silver efficacy is less robust, underpinning variability in clinical use ( Rodriguez-Arguello et al, 2018 ). Incorporating Ag and AgNPs into BG has been suggested as a potential alternative to antibiotics for reducing infection in a range of clinical applications ( Zhao et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

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A Novel Silver Bioactive Glass Elicits Antimicrobial Efficacy Against Pseudomonas aeruginosa and Staphylococcus aureus in an ex Vivo Skin Wound Biofilm Model

Wilkinson

Iveson

Catherall³

et al. 2018

Front. Microbiol.

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Biofilm infection is now understood to be a potent contributor to the recalcitrant nature of chronic wounds. Bacterial biofilms evade the host immune response and show increased resistance to antibiotics. Along with improvements in antibiotic stewardship, effective new anti-biofilm therapies are urgently needed for effective wound management. Previous studies have shown that bioactive glass (Bg) is able to promote healing with moderate bactericidal activity. Here we tested the antimicrobial efficacy of a novel BG incorporating silver (BgAg), against both planktonic and biofilm forms of the wound-relevant bacteria Pseudomonas aeruginosa and Staphylococcus aureus. BgAg was stable, long lasting, and potently effective against planktonic bacteria in time-kill assays (6-log reduction in bacterial viability within 2 h) and in agar diffusion assays. BgAg reduced bacterial load in a physiologically relevant ex vivo porcine wound biofilm model; P. aeruginosa (2-log reduction) and S. aureus (3-log reduction). BgAg also conferred strong effects against P. aeruginosa biofilm virulence, reducing both protease activity and virulence gene expression. Co-culture biofilms appeared more resistant to BgAg, where a selective reduction in S. aureus was observed. Finally, BgAg was shown to benefit the host response to biofilm infection, directly reducing host tissue cell death. Taken together, the findings provide evidence that BgAg elicits potent antimicrobial effects against planktonic and single-species biofilms, with beneficial effects on the host tissue response. Further investigations are required to elucidate the specific consequences of BG administration on polymicrobial biofilms, and further explore the effects on host–microbe interactions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Novel Silver Bioactive Glass Elicits Antimicrobial Efficacy Against Pseudomonas aeruginosa and Staphylococcus aureus in an ex Vivo Skin Wound Biofilm Model

Wilkinson

Iveson

Catherall³

et al. 2018

Front. Microbiol.

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“…The antiseptic mechanism of silver ions is to inhibit cell division, damage the bacterial cell membrane, disruption transport in the cell, which leads to its death. Silver, as a local antiseptic, has a different mechanism of action from antibiotics and multidirectional effect on a bacterial cell, which means that the likelihood of developing resistance to silver is very low [35,36].…”

Section: Silver Ionsmentioning

confidence: 99%

“…They include: Ū Polyhexamethylene biguanide (poliheksanid, PHMB) [2,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28], Ū Dequaline chloride [2,5,19,20,25,29,31,32], Ū Povidone iodine [33,34], Ū Sliver ions [26,30,[35][36][37][38][39][40], Ū Boric acid [41][42][43][44][45], Ū Chlorhexidine [46][47][48], Ū Lactic acid bacteria with or without estriol [49,50].…”

Section: Introductionmentioning

confidence: 99%

Polish Society of Gynecologists and Obstetricians recommendation on the use of antiseptics for treatment of inflammatory vaginitis

et al. 2020

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Undertook the analysis of literature, specialist knowledge and clinical experience on treatment options for non-specific vaginal inflammations of bacterial, fungal, mixed and unknown aetiology. The recommendation presents the current state of knowledge on this subject on the day of the published analysis. However, the expert group reserves the right to update this position in the event of new and significant scientific reports.

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“…73 However, some patients may present discomfort and pain when a silver-containing dressing is applied. 74 For patients in which silver-containing dressing is not indicated, dialkylcarbomoyl chloridecoated dressings may also be used for the management of infections and moisture imbalance in wounds. 75 These high-technology dressings are active also against methicillin-resistant S.aureus (MRSA) and Pseudomonas aeruginosa, two of the most difficult-to-treat bacteria.…”

Section: Topical Treatmentmentioning

confidence: 99%

<p>Management of digital ulcers in systemic sclerosis</p>

Barsotti¹,

Battista²,

Venturini³

et al. 2019

CWCMR

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Systemic sclerosis (SSc) is a rare disease characterized by autoimmune pathogenesis, alterations to the vascular system, and fibrosis of the skin and internal organs. Digital ulcers (DUs) are common in SSc patients, and represent a major burden for the patients. The management of DUs in systemic sclerosis is difficult, because it needs a multimodal therapeutic approach, as local treatment alone is usually insufficient and also systemic treatment with vasoactive drugs and modification of the lifestyle are usually required for healing of the wounds. In this review, we describe the optimal management of DUs according to recent literature and our clinical practice for systemic and local treatment of chronic digital wounds in SSc patients.

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A Scoping Review of the Use of Silver-impregnated Dressings for the Treatment of Chronic Wounds

Abstract: This research is made possible through the generous support of Exciton Technologies Inc.

Cited by 22 publications

References 0 publications

A Novel Silver Bioactive Glass Elicits Antimicrobial Efficacy Against Pseudomonas aeruginosa and Staphylococcus aureus in an ex Vivo Skin Wound Biofilm Model

A Novel Silver Bioactive Glass Elicits Antimicrobial Efficacy Against Pseudomonas aeruginosa and Staphylococcus aureus in an ex Vivo Skin Wound Biofilm Model

Polish Society of Gynecologists and Obstetricians recommendation on the use of antiseptics for treatment of inflammatory vaginitis

<p>Management of digital ulcers in systemic sclerosis</p>

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