A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives

Pelch, Katherine E.; Wignall, Jessica A.; Goldstone, Alexandra E.; Ross, Pam; Blain, Robyn; Shapiro, Andrew J.; Holmgren, Stephanie; Hsieh, Jui Hua; Svoboda, Daniel; Auerbach, Scott S.; Parham, Fredrick M.; Masten, Scott A.; Walker, Vickie R.; Rooney, Andrew A.; Thayer, Kristina A.

doi:10.1016/j.tox.2019.06.006

Cited by 203 publications

(116 citation statements)

References 138 publications

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“…Unfortunately, though, the safety of BPA analogues in comparison with that of BPA still perplexes the scientific community. Indeed, the endocrine disrupting potential of some BPs has been intensely investigated in recent years, with results showing that some analogues are more toxic than BPA (D. Chen et al., ; M. Y. Chen, Ike, & Fujita, ; Liu et al., ; Pelch et al., ; Ramilo, Valverde, Lago, Vieites, & Cabado, ; Rochester & Bolden, ; Roelofs, van den Berg, Bovee, Piersma, & van Duursen, ; Rosenmai et al., ; G. Russo et al., ). This resulted in products labeled as “BPA‐free” (Scherer, Maynard, Dolinoy, Fagerlin, & Zikmund‐Fisher, ).…”

Section: Introductionmentioning

confidence: 99%

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Russo

Varriale

Barbato

et al. 2019

Journal of Food Science

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Section: Introductionmentioning

confidence: 99%

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Russo

Varriale

Barbato

et al. 2019

Journal of Food Science

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“…Restrictions on the use of BPA in consumer products have led to its replacement by a number of BP analogues. Recently, more than 200 BPs have been identified as BPA analogues in consumer goods [ 23 , 24 , 25 ]. However, only a few have been considered relevant to human exposure even though they have widespread use ( Table 1 ) and their presence has been documented in the environment.…”

Section: Introductionmentioning

confidence: 99%

“…The selected compounds are structurally similar to BPA with analogous physicochemical properties ( Table 1 ), but their effects on animals and humans have been poorly studied [ 30 , 31 ]. Little is known about the toxicity of alternative BPs, and most of the toxicological information is limited to their endocrine disrupting potential [ 23 ]. Some studies suggested that these BPs have biological activities comparable to those of BPA due to their structural similarity [ 32 , 33 , 34 ]; other studies suggested that they have endocrine and toxicological activities even greater than BPA [ 35 , 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

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Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Lucarini

Krasniqi

Rosset³

et al. 2020

IJERPH

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Restrictions on the use of bisphenol A (BPA) in consumer products led to its replacement by various bisphenol (BP) analogues, yet young children’s exposure to these analogues has been poorly characterized so far. This study aimed to characterize infants’ and toddlers’ exposure to BPA and 14 emerging BP analogues (i.e., bisphenol AF, bisphenol AP, bisphenol B, bisphenol BP, bisphenol C (BPC), bisphenol E, bisphenol F (BPF), bisphenol G, bisphenol M (BPM), bisphenol P, bisphenol PH, bisphenol S (BPS), bisphenol TMC, and bisphenol Z). We extracted infants’ and toddlers’ urine from diapers (n = 109) collected in Swiss daycare centers as a practical and noninvasive alternative approach to urinary biomonitoring. Bisphenols were present in 47% of the samples, with BPC and BPM being the most frequently detected (23% and 25% of all samples, respectively). The mean concentrations of urinary BPS and BPF were greater than that of BPA. This contrasts with data reported previously. Furthermore, statistical analysis revealed a significant and negative correlation between urinary BPM concentration and the population’s age. Our results provide a first characterization of infants’ and toddlers’ exposure to bisphenols in Switzerland. This knowledge can be used to support ongoing biomonitoring studies and to prioritize exposure reduction and prevention strategies.

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“…BPA belongs to the class of EDs since it exerts estrogenic activity, even at concentrations below 1 ng/L. There are a limited number of studies on the BPA analogues' hormonal effects [9]. Some of the BPA substitutes seem to have more estrogenic effects than BPA [8].…”

Section: Introductionmentioning

confidence: 99%

Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice

Malaisé

Lencina

Cartier

et al. 2019

Preprint

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Background Bisphenol A (BPA), one of the highest-volume chemicals produced worldwide, has been identified as an endocrine disruptor. Many peer-reviewing studies have reported adverse effects of low dose BPA exposure, particularly during perinatal period (gestation and/or lactation). We previously demonstrated that perinatal oral exposure to BPA (via gavage of mothers during gestation and lactation) has long-term consequences on immune response and intestinal barrier functions. Due to its adverse effects on several developmental and physiological processes, BPA was removed from consumer products and replaced by chemical substitutes such as BPS or BPF, that are structurally similar and not well studied compare to BPA. Here, we aimed to compare perinatal oral exposure to these bisphenols (BPs) at two doses (5 and 50 mg/kg body weight (BW)/day (d)) on gut barrier and immune system in female offspring mice at adulthood (Post Natal Day PND70). Methods Pregnant female mice were orally exposed to BPA, BPS or BPF at 5 or 50 μg/kg BW/d from 15th day of gravidity to weaning of pups at PostNatal Day (PND) 21. Gut barrier function and the humoral and cellular immune responses of adult offspring (PND70) were analysed at intestinal and systemic levels. Results In female offspring, perinatal oral BP exposure led to adverse effects on intestinal barrier and immune response that were dependant of the BP nature (A, S or F) and dose of exposure. Stronger impacts were observed with BPS at the dose of 5µg/kg BW/d on inflammatory markers in feces associated with an increase of anti-E. coli IgG, revealing a defect of gut barrier. BPA and BPF exposure induced prominent changes at low dose in offspring mice, in term of gut barrier functions and cellular immune responses, provoking an intestinal and systemic Th1/Th17 inflammation. Conclusion These findings provide, for the first time, a comparative study of long-time consequences of BPA, S and F perinatal exposure by oral route in offspring mice. This work warms that it is mandatory to consider immune markers and dose in risk assessment associated to new BPA’s alternatives. Keywords: Bisphenol A, Bisphenol S, Bisphenol F, Immune responses, Perinatal exposure, Intestine, Th1/Th17, immunoglobulin, cytokines

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A scoping review of the health and toxicological activity of bisphenol A (BPA) structural analogues and functional alternatives

Cited by 203 publications

References 138 publications

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Are Canned Beverages Industries Progressively Switching to Bisphenol AF?

Exposure to New Emerging Bisphenols Among Young Children in Switzerland

Perinatal oral exposure to low doses of bisphenol A, S or F impairs gut barrier and immune functions in female offspring mice

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