A Screening Method to Identify Potential Endocrine Disruptors Using Chemical Toxicity Big Data and a Deep Learning Model with a Focus on Cleaning and Laundry Products

Lee, Inhye; Ji, Kyunghee

doi:10.5668/jehs.2021.47.5.462

Cited by 5 publications

(7 citation statements)

References 29 publications

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“…The Korean government has regulated DBP, DEHP, and BBzP to be under 0.1% in cosmetics since 2010 and re‐enacted the legislation as of January 2022, adding DnOP, DiBP, DiNP, and DiDP to the restricted substance list 35,36 . Despite the regulation, high levels of phthalates in PVC materials and consumer products were constantly reported 37 . The levels of DEHP, DiNP, and DiDP found in sludge from domestic wastewater treatment plants were the highest, accounting for 90% of the ΣPhthalate concentration 38 …”

Section: Resultsmentioning

confidence: 99%

“…The Korean Ministry of Environment (KMOE) has added DBP, DiNP, DEHP, and BBzP as restricted substances for use in electrical and electronic equipment as of 2019 55 . Therefore, the use of APs in electronic appliances increased as a replacement for phthalates 37 . In 2013, high levels of APs were detected in sediment samples collected from coastal locations near metal production and electronics facilities in Korea 56 .…”

Section: Resultsmentioning

confidence: 99%

“…55 Therefore, the use of APs in electronic appliances increased as a replacement for phthalates. 37 In 2013, high levels of APs were detected in sediment samples collected from coastal locations near metal production and electronics facilities in Korea. 56 Among the APs, DEHTP, DEHA, and TOTM detected in >90% of the samples were suggested as the predominant alternatives.…”

Section: Determinants In Association With Contaminants In Shdmentioning

confidence: 99%

“…39 Similarly, increased use of APs in various consumer products was reported in Korea. 37 APs detected in PVC materials, office supplies, and toys contributed up to 58% of the total plasticizers; particularly, DEHTP in PVC products was the highest, up to 579 times higher than the ΣPhthalates. 37 DEHTP is an isomeric compound of DEHP, increasingly used as replacement for phthalates in children's care and consumer products.…”

Section: Contaminants In Shdmentioning

confidence: 99%

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Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust

Kim

Park

Lee³

et al. 2022

Indoor Air

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Settled house dust (SHD) is a reservoir for various contaminants, including endocrine‐disrupting chemicals (EDCs), trace metals, and house dust mite allergens. This study aimed to characterize various chemical and biological contaminants in SHD and identify determinants governing the indoor contaminants. In total, 106 SHD samples were collected from 106 houses in Seoul and Gyeonggi Province, Korea, in 2021. Bedding dust samples were collected from 30 of these 106 houses. All participants completed a questionnaire comprised of housing and lifestyle‐related factors. The samples were analyzed for 18 organophosphate flame retardants (OPFRs), 16 phthalates, five alternative plasticizers (APs), seven trace metals, and two house dust mite allergens (Dermatophagoides farinae type 1 [Der f1] and Dermatophagoides pteronyssinus type 1 [Der p1]). A multiple regression analysis was conducted to identify the determinants governing the concentrations and profiles of various contaminants. OPFRs, phthalates, APs, and trace metals were detected in all SHD samples, indicating ubiquitous contamination in indoor environments. Among the three EDC groups, APs were detected at the highest concentrations (geometric mean [GM] (geometric standard deviation, [GSD]): 1452 (1.6) μg/g in total), followed by phthalates (GM (GSD): 676 (1.4) μg/g in total) and OPFRs (GM (GSD): 10 (1.4) μg/g in total). Der f1 was detected in all bedding dust samples with significantly higher levels than Der p1 (GM (GSD): 0.1 (1.8) μg/g vs. 1.4 × 10−3 (2.3) μg/g). The concentrations of OPFRs, plasticizers, and trace metals in SHD were significantly associated with the type and number of electronic appliances and combustion activities. Der f1 was significantly associated with the number of occupants and water penetration. Ventilation, vacuum cleaning, and wet cleaning or dry mopping significantly reduced the levels of most contaminants in SHD. As residents are persistently exposed to a wide array of pollutants, comprehensive and adequate measures are required to prevent potential exposures.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Determinants In Association With Contaminants In Shdmentioning

confidence: 99%

Section: Contaminants In Shdmentioning

confidence: 99%

See 2 more Smart Citations

Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust

Kim

Park

Lee³

et al. 2022

Indoor Air

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show abstract

“…In addition, their usage has shown reproductive toxicity in children 11,12 . Therefore, the governments of several countries, such as the United States, the European Union, and the Republic of Korea, are regulating the usage of phthalates in products 13,14 . The information of regulated phthalates in several countries is summarized in Table 1.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of phthalates using a pyrolyzer gas chromatography/mass spectrometry method

et al. 2023

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A pyrolyzer gas chromatography/mass spectrometry (GC/MS) method eliminates toxic solvents that burden our environment and can address the crucial problem of the solvent extraction GC/MS method. The purpose of this study is to establish an efficient quantitative analysis method for 10 phthalates that are regulated by the several governments. A change of concentrations over time for phthalates and internal standards was measured to verify the feasibility of using an auto sampler that facilitates analyzing multiple samples. Both standards maintained constant concentrations over the appropriate time for analysis. A certified reference material under the auspices of the Korea Research Institute of Standards and Science was used to verify the calibration curve obtained by the pyrolyzer GC/MS method, and a deviation was considered similar to the solvent extraction GC/MS method. Then, the limit of detection and limit of quantitation values were confirmed for various consumer products. To verify the reliability of the method, a comparative test with several accredited testing institutes was conducted, and the results were within the standard deviations of the results provided by the institutes. These results indicate that the pyrolyzer GC/MS method can be used in not only screening but also in accurate quantitative analysis.

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Thyroid hormone disrupting potentials of benzisothiazolinone in embryo-larval zebrafish and rat pituitary GH3 cell line

Kwon

Jeong

Kho

et al. 2023

Ecotoxicology and Environmental Safety

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A Screening Method to Identify Potential Endocrine Disruptors Using Chemical Toxicity Big Data and a Deep Learning Model with a Focus on Cleaning and Laundry Products

Cited by 5 publications

References 29 publications

Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust

Simultaneous assessment of organophosphate flame retardants, plasticizers, trace metals, and house dust mite allergens in settled house dust

Quantitative analysis of phthalates using a pyrolyzer gas chromatography/mass spectrometry method

Thyroid hormone disrupting potentials of benzisothiazolinone in embryo-larval zebrafish and rat pituitary GH3 cell line

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