A screening study on the mutagen formation potential of 44 pesticides

Takanashi, Hirokazu; Kishida, Misako; Abiru, Kazuya; Kondo, Takashi; Kameya, Takashi; Matsushita, Taku; Nakajima, Tsunenori; Ohki, Akira

doi:10.2166/aqua.2013.021

Cited by 3 publications

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“…If a compound is removed from the aqueous phase by entrapment in flocs during coagulation or by adsorption onto PAC particles, it will not contact chlorine, which is applied to the water in the final disinfection process. subsequent chlorination by using mutagenicity formation potential (MFP) (Takanashi et al 2013, Takanashi et al 2014, Takanashi et al 2016) as an index of toxicity induced after chlorination. The investigation did not address the effectiveness of ozonation.…”

Section: Mutagenicity Formation Potential Of Compounds Difficult To R...mentioning

confidence: 99%

“…The mutagenicity of raw drinking water is dramatically increased after chlorination (Cheh et al 1980, Vartiainen andLiimatainen 1986), a clear indication that mutagenic by-products are generated during chlorination. The increase of mutagenicity might be partly due to pesticides in the raw water, because some pesticide solutions have evinced mutagenicity after chlorination although they did not before chlorination (Takanashi et al 2013). The fact that some pesticide TPs have also increased mutagenicity after chlorination (Takanashi et al 2014) may partly account for the increase of mutagenicity.…”

Section: Introductionmentioning

confidence: 99%

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Removals of pesticides and pesticide transformation products during drinking water treatment processes and their impact on mutagen formation potential after chlorination

et al. 2018

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Removal efficiencies of 28 pesticide transformation products (TPs) and 15 parent pesticides during steps in drinking water treatment (coagulation-sedimentation, activated carbon adsorption, and ozonation) were estimated via laboratory-scale batch experiments, and the mechanisms underlying the removal at each step were elucidated via regression analyses. The removal via powdered activated carbon (PAC) treatment was correlated positively with the log K at pH 7. The adjusted coefficient of determination (r) increased when the energy level of the highest occupied molecular orbital (HOMO) was added as an explanatory variable, the suggestion being that adsorption onto PAC particles was largely governed by hydrophobic interactions. The residual error could be partly explained by π-π electron donor-acceptor interactions between the graphene surface of the PAC particles and the adsorbates. The removal via ozonation correlated positively with the energy level of the HOMO, probably because compounds with relatively high energy level HOMOs could more easily transfer an electron to the lowest unoccupied molecular orbital of ozone. Overall, the TPs tended to be more difficult to remove via PAC adsorption and ozonation than their parent pesticides. However, the TPs that were difficult to remove via PAC adsorption did not induce strong mutagenicity after chlorination, and the TPs that were associated with strong mutagenicity after chlorination could be removed via PAC adsorption. Therefore, PAC adsorption is hypothesized to be an effective method of treating drinking water to reduce the possibility of post-chlorination mutagenicity associated with both TPs and their parent pesticides.

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Section: Mutagenicity Formation Potential Of Compounds Difficult To R...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Removals of pesticides and pesticide transformation products during drinking water treatment processes and their impact on mutagen formation potential after chlorination

et al. 2018

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“…They were focused on in this study because they are the pesticides listed in "Complementary Items for Setting the Targets for Water Quality Management in Japan" document by the Ministry of Health, Labour and Welfare Japan. The mutagenicity data and the MFP data of these eight pesticides were obtained from our previous study (Takanashi et al, 2013a). The PTPWs of these eleven pesticides were selected based on our review article (Takanashi et al, 2013b).…”

Section: Chemicalsmentioning

confidence: 99%

“…These facts triggered research interests on whether pesticides and PTPWs produce mutagens when they react with chlorine. Thus, we published the test results on the mutagenicity and the mutagen formation potential (MFP) of 44 pesticides upon chlorination (Takanashi et al, 2013a), but the results were limited only for pesticides and no PTPWs were tested.…”

Section: Introductionmentioning

confidence: 99%

A Screening Study of Mutagen Formation Potential (MFP) of Pesticide Transformation Products in Water Environments (PTPWs) to Investigate the MFP Changes from their Parent Pesticides through Transformations

Takanashi

Hama

Nakajima

et al. 2014

J. of Wat. ^|^ Envir. Tech.

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The mutagenicity of one pesticide and 20 pesticide transformation products in water environments (PTPWs), the mutagen formation potential (MFP) of three pesticides and 28 PTPWs were investigated with the Ames Salmonella mutagenicity assay. The mutagenicity of 2-hydroxybenzyl alcohol (a PTPW of iprobenfos) was positive before chlorination. Out of 28 PTPWs, 18 were positive for the MFP. The difference of the MFP distributions between the parent pesticides and their PTPWs was tested statistically, indicating no increase in the MFP through the transformations. Of the 28 couples of parent pesticides and their PTPWs tested, seven couples increased their MFP through the transformations. The greatest ratio of the increase was 38, which was observed for iprobenfos and its PTPW 3-hydroxybenzyl alcohol.

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Identification of a mutagenic chlorination by-product produced from (E)-1, 3-dichloropropene (a component of nematocide DD) by using high resolution LC/MS and multivariate analysis

et al. 2018

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A screening study on the mutagen formation potential of 44 pesticides

Cited by 3 publications

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Removals of pesticides and pesticide transformation products during drinking water treatment processes and their impact on mutagen formation potential after chlorination

Removals of pesticides and pesticide transformation products during drinking water treatment processes and their impact on mutagen formation potential after chlorination

A Screening Study of Mutagen Formation Potential (MFP) of Pesticide Transformation Products in Water Environments (PTPWs) to Investigate the MFP Changes from their Parent Pesticides through Transformations

Identification of a mutagenic chlorination by-product produced from (E)-1, 3-dichloropropene (a component of nematocide DD) by using high resolution LC/MS and multivariate analysis

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