A search for a characteristic illness in children with serological evidence of viral or toxoplasma infection

Edwards, J M; Kessel, Irena; Gardner, S. D.; Eaton, Barbara; Pollock, T.M.; Fleck, D. G.; Gibson, Peter H.; Woodroof, M.; Porter, Allison

doi:10.1016/s0163-4453(81)91863-6

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…In the United Kingdom, the prevalence has been analysed in children but not, except inoutline, in adults (Cossart et al, 1975;Edwards et al, 1981). We now report on the prevalence of anti-B19 in all age groups of the general population in England and Wales.…”

Section: Introductionmentioning

confidence: 99%

The prevalence of antibody to human parvovirus B 19 in England and Wales

Cohen¹,

Buckley²

1988

Journal of Medical Microbiology

307

163

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Summary. The prevalence of antibody to human parvovirus B19 (anti-B19 IgG) in England and Wales was measured by an antibody-capture radioimmunoassay. Over 2000 sera were examined; 1422 from the general population, 374 from unselected children admitted to hospital and 300 from women attending an antenatal clinic. Waning levels of maternally-derived antibody were found in infants under 1 year old. In children 1-5 years old, 5-15% had anti-B19 IgG and this rose to 5040% in older children, young adults and women of child-bearing age. In older people, the prevalence of anti-B19 IgG increased with age, rising to more than 85% in those over 70 years old.

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Section: Introductionmentioning

confidence: 99%

The prevalence of antibody to human parvovirus B 19 in England and Wales

Cohen¹,

Buckley²

1988

Journal of Medical Microbiology

307

163

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“…The human parvovirus (Cossart et al 1975;Summers, Jones & Anderson, 1983) has been shown to be the cause of aplastic episodes in sickle cell anaemia (Pattison et al 1981;Serjeant et al 1981) and other chronic haemolytic anaemias (Duncan et al 1983;Kelleher et al 1983;Rao et al 1983). These are rare conditions in the UK, but infection with the virus is common in that 60 % of the adult population in the UK are seropositive (Cohen, Mortimer & Pereira, 1983), infection occurring most often in children of primary school age (Edwards et al 1981). The symptoms which accompany infection in haematologically normal people have until now been obscure.…”

Section: Introductionmentioning

confidence: 99%

An outbreak of erythema infectiosum associated with human parvovirus infection

Anderson¹,

Lewis²,

Kidd³

et al. 1984

J. Hyg.

316

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Erythema infectiosum (EI) or fifth disease is a mild, acute exanthematous disease, occurring mainly among children, for which a causative virus has long been sought. In May 1983 an outbreak of exanthematous illness was reported in a primary school in North London. Children attending the school were investigated by questionnaire and 162 (43.9%) reported an illness with the features of EI. In each of 36 cases investigated virologically the illness was associated with parvovirus infection. Moreover, pre-existing antibody to parvovirus was correlated with protection from EI in 16 of 17 close family contacts of cases. We propose therefore that EI is the common manifestation of infection with the human parvovirus.

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“…Seroepidemiological studies, on the other hand, revealed that the infection is widespread and age-stratification of antibody prevalence showed that the infection was most often acquired in childhood. [22][23][24] As more informative laboratory tests became available, it was possible to show that parvovirus B19 was the cause of a common childhood exanthem, erythema infectiosum (EI, also known as fifth disease or 'slapped cheek' disease). [24][25][26][27] Although clinically similar to and difficult to distinguish from rubella, EI had been recognised as a distinct clinical entity for more than a hundred years but hitherto its aetiology had been unknown.…”

Section: Disease Manifestations In Non-pregnant Patientsmentioning

confidence: 99%

Parvovirus B19 Infection in Pregnancy

Cohen

Kumar

2005

Fet. Matern. Med. Rev.

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Parvoviruses are widespread in nature, with a diversity of virus types affecting many animal species, usually in a species-specific manner. Some members of the parvovirus family give rise to asymptomatic infections but others are highly pathogenic, causing disease not only in adults but also in the young, the newborn and in the fetus. Parvoviruses of animals have for long been regarded as agents of reproductive failure and parvovirus B19 was recognised as a cause of fetal loss in humans in the 1980s. Moreover, following the control of congenital rubella by pre-pubertal and child vaccination, parvovirus B19 infection has emerged as probably the leading cause of viral embryopathy. This review will focus on the laboratory diagnosis of parvovirus B19 infection following exposure in pregnancy. The indications for testing maternal and fetal samples and the interpretation of test results will be discussed and a section is included on clinical management of the infection in pregnancy. The obstetric outcome in pregnant women who seroconvert will be reviewed.

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A search for a characteristic illness in children with serological evidence of viral or toxoplasma infection

Cited by 21 publications

References 7 publications

The prevalence of antibody to human parvovirus B 19 in England and Wales

The prevalence of antibody to human parvovirus B 19 in England and Wales

An outbreak of erythema infectiosum associated with human parvovirus infection

Parvovirus B19 Infection in Pregnancy

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