A search for retrovirus infection in systemic lupus erythematosus and rheumatoid arthritis.

Pelton, B K; North, M. E.; Palmer, R. F.; Hylton, W; Smith‐Burchnell, Caroline; Sinclair, A; Malkovsky, Miroslav; Dalgleish, A. G.; Denman, A. M.

doi:10.1136/ard.47.3.206

Cited by 30 publications

(5 citation statements)

References 17 publications

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“…Evidence of retroviral genomic material in individual patients with autoimmune diseases has also been described, for example, the demonstration of HIV-1-related messenger RNA sequences, by in situ hybridization, in peripheral blood cells of a patient with systemic lupus erythematosus (SLE) (20), and the development of A-type retroviral particles in lymphoid cell cocultures of salivary gland homogenate derived from a patient with Sjogren's syndrome (21). Attempts to isolate a replicating retrovirus from the peripheral blood cells of SLE patients, however, have been unsuccessful (22).…”

mentioning

confidence: 99%

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Ranki

Kurki

Riepponen

et al. 1992

Arthritis & Rheumatism

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Objective. To study the relationship between antibodies that recognize human retroviral proteins and the presence of clinical features and ribonucleoprotein antibodies in patients with autoimmune connective tissue diseases (CTDs).Methods. Antibodies against native human immunodeficiency virus type 1 (HIV-1) and human T cell leukemiahymphoma virus type I, recombinant HIV-1 Nef protein, and ribonucleoprotein antigens were determined by immunoblot of sera from 65 prospectively studied patients with definite ur suspected CTDs of autoimmune type.Results. Antibodies to retroviral proteins (ARP), most frequently to HIV Gag proteins p55 and p24, were found in 64% of 22 patients with systemic lupus erythematosus (SLE), in 63% of 8 patients with discoid LE From the

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mentioning

confidence: 99%

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Ranki

Kurki

Riepponen

et al. 1992

Arthritis & Rheumatism

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“…However, CA reactivity in EIB was not perfectly correlated with whole virus EIA reactivity; differences in antigen conformation or purity may have been responsible. HTLV-reactive antibodies were not over-represented in our SLE patient sera (11)(12)(13)(14)(15), but the sensitivity of the test for these antibodies was not optimized.…”

Section: Discussionmentioning

confidence: 99%

Increased Antiretroviral Antibody Reactivity in Sera from a Defined Population of Patients with Systemic Lupus Erythematosus

Blomberg

Nived

Pipkorn

et al. 1994

Arthritis & Rheumatism

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Objective. The implied role of retroviruses in the pathogenesis of murine systemic lupus erythematosus (SLE) led us to study antiretroviral antibodies in a population-based SLE cohort.Methods. Immunoassays using whole virus and synthetic peptides were performed on sera from 72 patients with SLE and 88 control subjects.Results. Reactions with whole baboon endogenous virus occurred more frequently in patients with SLE, and correlated with the presence of anti-RNP and anti8m. Some retroviral env and gag peptides, several of which were similar to U1 small nuclear RNP, reacted Submitted for publication September 9, 1992; accepted in revised form June 10, 1993. more strongly in patients with SLE, and their presence was correlated with discoid rash, hematologic disorder, and other symptoms. Conclusion. These results provide circumstantial evidence for involvement of retroviruses in the pathogenesis of human SLE; further studies should be carried out using other techniques for measurement of retroviral expression.

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“…The published literature proposes various roles for class I (HERV-E, and to a lesser extent -W, and -H) and class II (HERV-K) HERVs in autoimmune diseases [ 70 , 71 , 72 , 73 ]. A common denominator among these papers is the idea that their transcriptional upregulation will trigger various aspects of an antiviral immune response, including autoantibodies against retroviral proteins [ 74 , 75 , 76 , 77 ]. A popular suggestion is that HERV proteins may trigger autoimmunity by molecular mimicry [ 70 , 78 ] through accidental similarities between these proteins and other self-proteins.…”

Section: Transposable Elements In the Human Genomementioning

confidence: 99%

Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus

Ukadike

Mustelin

2021

JCM

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Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. While its etiology remains elusive, current understanding suggests a multifactorial process with contributions by genetic, immunologic, hormonal, and environmental factors. A hypothesis that combines several of these factors proposes that genomic elements, the L1 retrotransposons, are instrumental in SLE pathogenesis. L1 retroelements are transcriptionally activated in SLE and produce two proteins, ORF1p and ORF2p, which are immunogenic and can drive type I interferon (IFN) production by producing DNA species that activate cytosolic DNA sensors. In addition, these two proteins reside in RNA-rich macromolecular assemblies that also contain well-known SLE autoantigens like Ro60. We surmise that cells expressing L1 will exhibit all the hallmarks of cells infected by a virus, resulting in a cellular and humoral immune response similar to those in chronic viral infections. However, unlike exogenous viruses, L1 retroelements cannot be eliminated from the host genome. Hence, dysregulated L1 will cause a chronic, but perhaps episodic, challenge for the immune system. The clinical and immunological features of SLE can be at least partly explained by this model. Here we review the support for, and the gaps in, this hypothesis of SLE and its potential for new diagnostic, prognostic, and therapeutic options in SLE.

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A search for retrovirus infection in systemic lupus erythematosus and rheumatoid arthritis.

Cited by 30 publications

References 17 publications

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Antibodies to retroviral proteins in autoimmune connective tissue disease. Relation to clinical manifestations and ribonucleoprotein autoantibodies

Increased Antiretroviral Antibody Reactivity in Sera from a Defined Population of Patients with Systemic Lupus Erythematosus

Implications of Endogenous Retroelements in the Etiopathogenesis of Systemic Lupus Erythematosus

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