A second look: No effect of the COMT Val158Met polymorphism on conflict adaptation in youth with chromosome 22q11.2 deletion syndrome

Stoddard, Joel; Takarae, Yukari; Simon, Tony J.

doi:10.1016/j.schres.2011.12.011

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…These results are in line with some previous studies from our group and those of others, suggesting that 22q11.2DS COMT Met carriers are more severely affected in terms of cognition and behavior compared to 22q11.2DS Val carriers (Gothelf et al 2005;Schneider et al 2012). Other studies, however, did not find such an association between COMT genotype and the cognitive and psychiatric phenotype of 22q11.2DS (Stoddard et al 2012;Monks et al 2014). …”

Section: Comt Genotype and Mother-child Interactionsupporting

confidence: 93%

Mother–Child Interaction as a Window to a Unique Social Phenotype in 22q11.2 Deletion Syndrome and in Williams Syndrome

Weisman

Feldman

Burg-Malki

et al. 2015

J Autism Dev Disord

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Mother-child interactions in 22q11.2 Deletion syndrome (22q11.2DS) and Williams syndrome (WS) were coded for maternal sensitivity/intrusiveness, child's expression of affect, levels of engagement, and dyadic reciprocity. WS children were found to express more positive emotions towards their mothers compared to 22q11.2DS children and those with developmental delay in a conflict interaction. During the same interaction, dyads of 22q11.2DS children were characterized by higher levels of maternal intrusiveness, lower levels of child's engagement and reduced reciprocity compared to dyads of typically developing children. Finally, 22q11.2DS children with the COMT Met allele showed less adaptive behaviors than children with the Val allele. Dyadic behaviors partially coincided with the distinct social phenotypes in these syndromes and are potential behavioral markers of psychopathological trajectory.

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