A secondary metabolite amberin from<i>Amberboa ramosa</i>

Ibrahim, Muhammad; Imran, Muhammad; Ali, Bakhat; Hussain, Riaz; Rehmani, Fouzia Sultana; Malik, Abdul

doi:10.1080/10286020.2011.647503

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Literature survey revealed that triterpenoids, flavonoids, steroids and sesquiterpene lactones have previously been reported from this species [4,5]. In this study we have isolated four guaianolides (sesquiterpenes) out of which Amberbin C ( 1 ) was identified as a new compound while other three Amberin ( 2 ) [6], Amberbin A ( 3 ) and Amberbin B ( 4 ) [7] were previously been reported from the same source. All structures were elucidated by using different spectroscopic techniques like UV, IR, EI-MS, 1D and 2D NMR techniques.…”

Section: Introductionmentioning

confidence: 71%

Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa

Ibrahim

Farooq

Hussain

et al. 2013

Chemistry Central Journal

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BackgroundAlzheimer’s disease (AD) is characterized by a progressive memory loss that leads to a profound emotional disturbance in later stages. As no safe and effective drug is yet available for the treatment of AD, secondary metabolites from plants may be instrumental in meeting this challenge. Keeping in view this point we evaluated sesquiterpenes of medicinal plant Amberboa ramosa for their cholinesterase inhibitory activity.ResultsFour sesquiterpene lactones have been isolated from the ethyl acetate soluble fraction of Amberboa ramosa. In which one compound Amberbin C (1) was found to be new while other three Amberin (2), Amberbin A (3), and Amberbin B (4) were previously reported ones. The structures of the isolated compounds were elucidated using different spectroscopic techniques. Isolated compounds were tested for their inhibitory potential against acetyl cholinesterase and butyryl cholinesterase enzymes. All compounds showed excellent inhibitory activities against acetyl cholinesterase and butyryl cholinesterase.ConclusionsA new sesquiterpene lactone has been isolated and fully characterized, the sesquiterpene lactones from Amberboa ramosa showed good inhibitory activities against acetyl cholinesterase and butyryl cholinesterase enzymes, this study indicated that sesquiterpene lactone can become interesting lead molecules in drug development against Alzheimer’s disease (AD).

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Section: Introductionmentioning

confidence: 71%

Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa

Ibrahim

Farooq

Hussain

et al. 2013

Chemistry Central Journal

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“…Te phytochemical investigations have confrmed the presence of sesquiterpenes, favonoid (jaceosidine, apigenin, chrysoeriol, 5,7,4′-trihydroxy-3,8-dimethoxylfavone), long-chain esters, cycloartane-triterpenoids, lactone (cynaropicrin, amberen, ramosine), glycoside (Kaempferol 5-O-β-D-gluco-pyranoside), alkaloids, carbohydrates, tannins, saponins, anthraquinones, and steroids in O. ramosa Roxb. extracts [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Oligochaeta ramosa (Roxb.) Extract Regulates Lipid Metabolism and Exerts Hepatoprotective Effects in Cadmium-Induced Hepatic Injury in Rats

Aslam

Ahmad

Hassan

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Environmental pollutants present a potential source of toxicity when exposed to humans. The study was aimed at investigating the potential of Oligochaeta ramosa (Roxb.) as a hepatoprotective agent in cadmium-induced hepatotoxicity causing lipid profile disturbance. The aqueous methanolic (30 : 70 v/v) extract of O. ramosa Roxb. (AME.Or) was subjected to preliminary phytochemical analysis, whereas the antioxidant activity of its constituents was investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The hepatoprotective and antihyperlipidemic effects of AME.Or was investigated by dividing animals into five groups (A–E). Animals were either treated with normal saline or CdCl2 (6.5 mg/kg, intraperitoneally) followed by treatment with silymarin (100 mg/kg), or AME.Or (200 mg/kg) and AME.Or (400 mg/kg) for consecutive three weeks. Blood samples were collected, and the serum lipid profile was assessed on the 11th and 21st day of treatment. Histopathological analysis was performed after euthanization. In vitro analysis of AME.Or revealed 64% inhibition as free radicals scavenging potential during DPPH, total phenolic content (TPC) (79.92 mgGAE/g), and total flavonoids content (TFC) (38.75 mgRE/g). The group intoxicated with CdCl2 showed significantly high ( p ≤ 0.05 ) levels of the liver function indicators and lipid profile than in the control group. The higher dose of AME.Or (400 mg/kg) significantly decreased the aspartate aminotransferase (AST), alanine transferase (ALT), alkaline phosphatase (ALP), total bilirubin ( p ≤ 0.001 ), decreased total cholesterol and triglycerides ( p ≤ 0.01 ) while significantly increased high density lipoprotein (HDL; p ≤ 0.01 ) as compared to the intoxicated group. The histopathological analysis of the liver revealed signs of necrosis in the intoxicated group, while AME.Or treated groups showed marked improvement. The findings accentuate the therapeutic importance of O. ramosa (Roxb.) as a hepatoprotective remedy.

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“…Phytochemical investigations revealed the presence of flavone (jaceosidine), sesquiterpene lactone (cynaropicrine, amberin, amberbins A, amberbins B, apigenin, crysoeriol, jaseocidine, ramosine, tricontane), longchain esters, cycloartane-triterpenoids and glycoside (5,7,4'-trihydroxy-3,8-dimethoxylflavone 5-O-β-D-gluco -pyranoside) (Forgacs et al, 1981;Khan et al, 2004;Khan et al, 2005a;Khan et al, 2005b;Ibrahim et al, 2010;Ibrahim et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological evaluation and validation for the folkloric use of <i>Oligochaeta ramose</i> in constipation and diarrhea

Hussain¹,

Raza²,

Janbaz³

2014

Bangladesh J Pharmacol

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Crude extract of Oligochaeta ramosa and its fractions were studied to rationalize its traditional use in GIT disturbance. In spontaneous contracting jejunum preparation, O. ramosa (0.01-1.0 mg/mL) caused a transient spasmogenic effect followed by the spasmolytic effect at higher doses (3.0-10.0 mg/mL). In atropinized jejunum preparation, O. ramosa inhibit the spontaneous and K + (80 mM)-induced contraction at the similar doses (0.01-1.0 mg/mL), suggesting calcium channel blocking effect. The calcium channel blocking effect was confirmed when pretreatment of tissue with O. ramosa produced a dose-dependent shift in Ca 2+ dose-response curve to the right, similar to that produced by the verapamil. Activity-directed fractionation revealed that the spasmolytic effect is concentrated in the dichloromethane fraction while, aqueous fraction contains both spasmogenic and spasmolytic constituents. This study validate the presence of both spasmogenic and spasmolytic components mediated through muscarinic receptor activation and calcium channel blockade respectively, which may explain its traditional uses in constipation and diarrhea. Article Info

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A secondary metabolite amberin fromAmberboa ramosa

Cited by 6 publications

References 12 publications

Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa

Acetyl and butyryl cholinesterase inhibitory sesquiterpene lactones from Amberboa ramosa

Oligochaeta ramosa (Roxb.) Extract Regulates Lipid Metabolism and Exerts Hepatoprotective Effects in Cadmium-Induced Hepatic Injury in Rats

Pharmacological evaluation and validation for the folkloric use of <i>Oligochaeta ramose</i> in constipation and diarrhea

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