A self-assembled framework that interpenetrates in crystal but does not interpenetrate in solution

Conjugating aldoxorubicin to supramolecular organic frameworks: polymeric prodrugs with enhanced therapeutic efficacy and safety

“…Dialysis experiments (bag M W cur-off: 1000 Dalton) supported that this conjugation proceeded quantitatively (Fig. S1, ESI†), 39,40 because UV-vis absorption spectroscopy showed no observable amount of free AlDox diffused from the dialysis bag after 4 hours at pH 7.4, 41 whereas for the solution of free AlDox of the identical concentration, 97% diffusion was observed (Fig. S2, ESI†).…”

Supramolecular Organic Frameworks: Exploring Water-Soluble, Regular Nanopores for Biomedical Applications

“…The sizes of dSOFs were typically 50 to 150 nm, which rival nanoscale macromolecular carriers in utilizing the EPR effect and also allow considerable maintenance of included drugs. Their aperture size was defined (2.1 nm) and large enough to include many drugs and linear biomacromolecules but not rigid guests beyond this size . Thus, guest inclusion has also been used to evaluate the aperture of the SOFs.…”

“…The dynamic character of dSOFs made it difficult to investigate the structure or possible defects of their apertures in solution. However, the crystal structure of a 3D dSOF did confirm the formation of the porous framework through the encapsulation of CB[8] for appended hydrophobic arms of the tetrahedral component …”

“…Their aperture size was defined (2.1 nm) and large enough to include many drugs and linear biomacromolecules but not rigid guests beyond this size. 40 Thus, guest inclusion has also been used to evaluate the aperture of the SOFs. Although T1a−h are semirigid, fully conjugated precursors can also form similar frameworks.…”

“…However, the crystal structure of a 3D dSOF did confirm the formation of the porous framework through the encapsulation of CB [8] for appended hydrophobic arms of the tetrahedral component. 40…”