A self-gelling powder based on polyacrylic acid/polyacrylamide/quaternate chitosan for rapid hemostasis

Tan, Zhouying; Li, Xi; Yu, Chaojie; Yao, Mengmeng; Zhao, Zhongming; Guo, Bingyan; Liu, Liang; Wei, Yuping; Yao, Fanglian; Zhang, Hong; Li, Junjie

doi:10.1016/j.ijbiomac.2023.123449

Cited by 39 publications

(16 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The broad peak at 3000–3500 cm –1 is generated by the hydroxyl (–OH) and the stretching vibration of N–H bonds . The peak at 1654 cm –1 represents the stretching vibration of amide I bonds (CO). , The peak at 1600 cm –1 represents the bending vibration of amide II bonds (N–H) . And the peak at 1043 cm –1 is generated by the vibration of the P–O bond in PO 4 3– . , …”

Section: Resultsmentioning

confidence: 99%

Terpolymer-Hydroxyapatite Hybrid Hydrogel Prepared by Photopolymerization Under Green LED Irradiation for Wound Hemostasis

Zhao,

Deng,

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

Multifunctional materials with hemostasis, adhesive, and antibacterial properties must be developed to meet the demand for wound hemostasis. In this work, a hybrid hydrogel (ATD-HAp hydrogel) based on a terpolymer and hydroxyapatite (HAp) was prepared by photopolymerization within 1 min under green LED irradiation. The polymer chains of ATD-HAp hydrogel with adjustable tensile and adhesion properties and antibacterial properties were formed by copolymerization of acrylamide, N-[tris(hydroxymethyl)methyl] acrylamide, and dimethyldiallylammonium chloride and methacrylated carboxymethyl chitosan as a cross-linking agent. HAp was added to the hydrogel to release Ca 2+ to promote coagulation. The results showed that ATD-HAp hydrogel had good tensile (196.7 kPa), wet-adhesive (10.3 kPa), self-healing, antibacterial properties, and coagulation. And the ATD-HAp hydrogel had excellent blood compatibility and biocompatibility. Furthermore, the experimental results of the hemostasis model in mice proved that the ATD-HAp hydrogel can significantly shorten the hemostasis time and reduce blood loss. Therefore, the ATD-HAp hydrogel has great potential in the field of wound hemostasis.

show abstract

Section: Resultsmentioning

confidence: 99%

Terpolymer-Hydroxyapatite Hybrid Hydrogel Prepared by Photopolymerization Under Green LED Irradiation for Wound Hemostasis

Zhao,

Deng,

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

show abstract

“…Challenging scenarios of wound bleeding frequently occur in real-life situations, imposing stringent requirements for the development of hemostatic hydrogels capable of effectively addressing these complexities. [112][113][114] Presently, natural polymers, synthetic polymers, inorganic compounds, and metal-based materials are utilized in the formulation of hemostatic hydrogels. 115 The common natural polymer hemostatic materials are polysaccharide and collagen.…”

Section: Hemostasismentioning

confidence: 99%

Hydrogel-based dressings designed to facilitate wound healing

Zhang,

Liu,

Cheng

et al. 2024

Mater. Adv.

View full text Add to dashboard Cite

show abstract

“…It is worth noting that some hemostatic powders can transform into hydrogels, which improves the portability of hemostatic materials. 16–19 The advantages of powder include convenience, time efficiency, diverse application methods, and suitability for large-area wounds. However, hemostatic powder cannot be applied to noncompressible torso hemostasis.…”

Section: Introductionmentioning

confidence: 99%