A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material

Yin, Huishuang; Song, Peiqin; Chen, Xingyu; Huang, Huihua

doi:10.1016/j.ijbiomac.2022.09.060

Cited by 36 publications

(17 citation statements)

References 39 publications

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“…Similarly, by using imine bonds, Li et al [49] generated self-healing hydrogel dressings composed of aldehyde-modified sodium hyaluronate (AHA), hydrazine-modified sodium hyaluronate (ADA), and aldehyde modified cellulose nanocrystals (oxi-CNC) (Figure 4c). When these hydrogel dressings are separated into two pieces, they can self-heal and rejoin In view of the problems encountered in previous studies, Yin et al [47] published a paper in which they described hydrogel dressings constructed using the aldehyde group of oxidized microcrystalline cellulose (OMCC) from pineapple peel (PP) crosslinked with the amino group of carboxymethyl chitosan (CMCS) from hericium erinaceus residues (HER) and using the Schiff base reaction for its construction (Figure 4b). Due to the continuous fracturing and regeneration of the imine bond, the researchers divided the network composed of the hydrogel dressing into two parts, and it took 5 h to achieve self-healing.…”

Section: Imine Bondsmentioning

confidence: 99%

Advances in Functional Hydrogel Wound Dressings: A Review

et al. 2023

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One of the most advanced, promising, and commercially viable research issues in the world of hydrogel dressing is gaining functionality to achieve improved therapeutic impact or even intelligent wound repair. In addition to the merits of ordinary hydrogel dressings, functional hydrogel dressings can adjust their chemical/physical properties to satisfy different wound types, carry out the corresponding reactions to actively create a healing environment conducive to wound repair, and can also control drug release to provide a long-lasting benefit. Although a lot of in-depth research has been conducted over the last few decades, very few studies have been properly summarized. In order to give researchers a basic blueprint for designing functional hydrogel dressings and to motivate them to develop ever-more intelligent wound dressings, we summarized the development of functional hydrogel dressings in recent years, as well as the current situation and future trends, in light of their preparation mechanisms and functional effects.

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Section: Imine Bondsmentioning

confidence: 99%

Advances in Functional Hydrogel Wound Dressings: A Review

et al. 2023

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“…In neutral or alkaline aqueous solutions, Schiff bases will form between the amino and aldehyde groups (aldimine condensation), which will hydrolyze in weakly acidic pH. 138…”

Section: Applications Of Peptide Hydrogelsmentioning

confidence: 99%

“…In neutral or alkaline aqueous solutions, Schiff bases will form between the amino and aldehyde groups (aldimine condensation), which will hydrolyze in weakly acidic pH. 138 Wang et al 139 designed the aldehyde-terminal peptide Nap-G D F D F D pY-CHO and used the carboxy-terminal peptide Nap-G D F D F D pY-COOH as a control, using Dox as an amine drug encapsulated in hydrogel to test the release of cumulative drug at different pH. The results showed that the release rate of Dox from the CHO-Dox gel was higher in acidic PBS solution than in alkaline PBS solution, and this phenomenon is consistent with the pH-dependent behavior of Schiff bases.…”

Section: Drug Releasementioning

confidence: 99%

Mechanisms and influencing factors of peptide hydrogel formation and biomedicine applications of hydrogels

Zhang,

Zhao,

2023

Soft Matter

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“…The compression strength of N05-2 and N05-4 basically restored to the initial value after 1 h. This is in contrast to other findings in which the higher recovery of hydrogels ascribes to the presence of a greater number of crosslinking Schiff base bonds in the network. [27,28] The faster healing rate of the N05 hydrogel group could be hypothesized as the remaining available hydrogen bonds and electrostatic interactions between the polymers. At a higher oxidation level, the dense crosslink structure may reduce the movement of the polymer, leading to lower support from physical bonds during the healing process.…”

Section: Self-healing Properties and Compression Testmentioning

confidence: 99%

Oxidized Xanthan Gum Crosslinked NOCC: Hydrogel System and Their Biological Stability from Oxidation Levels of the Polymer

Quan,

Do,

Luong

et al. 2023

Macromolecular Bioscience

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Dynamic hydrogel systems from N,O‐carboxymethyl chitosan (NOCC) have been investigated in the past years which has facilitated their widespread use in many biomedical engineering applications. However, the influence of the polymer's oxidation levels on the hydrogel biological properties has not been fully investigated. In this study, chitosan was converted into NOCC and introduced to react spontaneously with oxidized xanthan gum (OXG) to form several injectable hydrogels with controlled degradability. Different oxidation levels of xanthan gum, as well as NOCC/OXG volume ratios, were trialed. The infrared spectroscopy spectra verified chemical modification on OXG and successful crosslinking. With increasing oxidation levels, more dialdehyde groups were introduced into the OXG, resulting in changes in physical properties including gelation, swelling, and self‐healing efficiency. Under different volume ratios, the hydrogel showed a stable structure and rigidity with higher mechanical properties and a slower degradation rate. The shear‐thinning and self‐healing properties of the hydrogels were confirmed. In vitro assays with L929 cells showed the biocompatibility of all formulations although the use of a high amount of OXG15 and OXG25 limited the cell proliferation capacity. Findings in this study suggested a suitable amount of OXG at different oxidation levels in NOCC hydrogel systems for tissue engineering applications.This article is protected by copyright. All rights reserved

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A self-healing hydrogel based on oxidized microcrystalline cellulose and carboxymethyl chitosan as wound dressing material

Cited by 36 publications

References 39 publications

Advances in Functional Hydrogel Wound Dressings: A Review

Advances in Functional Hydrogel Wound Dressings: A Review

Mechanisms and influencing factors of peptide hydrogel formation and biomedicine applications of hydrogels

Oxidized Xanthan Gum Crosslinked NOCC: Hydrogel System and Their Biological Stability from Oxidation Levels of the Polymer

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