A self-powered and thermally-responsive drug delivery system based on conducting polymers

Ge, Dongtao; Qi, Rucai; Mu, Jing; Ru, Xiaoning; Hong, Shimin; Ji, Shan; Linkov, Vladimir; Shi, Wei

doi:10.1016/j.elecom.2010.05.035

Cited by 22 publications

(12 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the second type of release system, the molecules are delivered by applying an external electrical potential to oxidise and/or reduce the films [57]. In general, two types of stimulation protocols can be used named step potential and cyclic potential.…”

Section: Drug Deliverymentioning

confidence: 99%

“…In the first technique, the CP is electrochemically deposited in a metal substrate such as titanium foil [57]. In the second technique, the polymer film attached or detached from a metal substrate, for example, Pt or Au, is connected to a separate anode electrode such as Zn-or Mg-based alloys [62].…”

Section: Drug Deliverymentioning

confidence: 99%

“…Ge et al [57] used the first technique with the model drug adenosine triphosphate (ATP). The drug was incorporated into the polymer matrix during the electrochemical polymerisation of PPy by depositing the polymer on pure polished titanium foil.…”

Section: Drug Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

View full text Add to dashboard Cite

Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted.

show abstract

Section: Drug Deliverymentioning

confidence: 99%

Section: Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

View full text Add to dashboard Cite

show abstract

“…Recently, our group extended the application of PPy nanowire network to this field, obtaining an effective drug release system with high adenosine triphosphate (ATP) release efficiency [5]. 2 It is well known that CPs can be used as drug carriers due to their unique dopingdedoping and stimulus-responsive property [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], where drugs can be incorporated into CPs as dopants and then be released upon electrical stimulation. Therefore, the capacity of drug loading is dependent on the doping level (which is usually low) and the type of drugs is restricted to the charged and small molecules.…”

Section: Introductionmentioning

confidence: 99%

Enhanced drug loading capacity of polypyrrole nanowire network for controlled drug release

et al. 2013

Self Cite

View full text Add to dashboard Cite

For a conducting polymer (CP) based drug release system, drug loading is often accomplished by a doping process, in which drug is incorporated into polymer as dopant. Therefore, the drug loading capacity is relatively low and the range of drugs can be loaded is limited. In the present work, a polypyrrole (PPy) nanowire network is prepared by an electrochemical method and it is found that the micro-and nanogaps among the individual nanowires of the PPy nanowire network can be used as reservoir to store drugs. Therefore, the drug loading capacity is dependent on the volume of these micro-and nano-vacancies, instead of the doping level. The range of loaded drugs also can be theoretically extended to any drugs, instead of only charged dopants. In fact, it is confirmed here that both hydrophilic and lipophilic drugs can be loaded into the micro-and nano-gaps due to the amphilicity of the PPy nanowire network. As a result, both drug loading capacity and the range of drugs can be loaded are significantly improved. After being covered with a protective PPy film, controlled drug release from the prepared system is achieved by electrical stimulation (cyclic voltammetry, CV) and the amount of drug released can be controlled by changing the scan rate of CV and the thickness of the protective PPy film.

show abstract

“…Moreover, their electrchemical and physical properties can be altered and controlled through stimulation such as electricity and pH. Currently, nanostructured CPs such as polypyrrole (PPy), polyurethane, polyaniline (PANI) and their derivatives have been used in biosensors, neural probes, and controlled release systems, etc …”

Section: Introductionmentioning

confidence: 99%