A sensitive electrochemical aptasensor based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles and flower-like MnO<sub>2</sub> nanosphere functionalized multi-walled carbon nanotubes

Xu, Wenju; Xue, Shuwen; Yi, Huayu; Jing, Pei; Chai, Yaqin; Yuan, Ruo

doi:10.1039/c4cc08860c

Cited by 68 publications

(21 citation statements)

References 27 publications

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“…In order to fabricate a stable matrix for the growth of MIP, gold nanoparticles (AuNPs) were assembled on the GCE surface first. The AuNPs can also function as the signal amplifier in this sensing system (Cao et al, 2011;Huang et al, 2015;Xu et al, 2015). The AuNPs were prepared according to the previous reports with a slight modification (Frens, 1973).…”

Section: Preparation Of the Metronidazole Imprinted Biomimetic Sensormentioning

confidence: 99%

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

Yan

Liu

et al. 2016

Biosensors and Bioelectronics

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Section: Preparation Of the Metronidazole Imprinted Biomimetic Sensormentioning

confidence: 99%

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

Yan

Liu

et al. 2016

Biosensors and Bioelectronics

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“…[13][14][15][16] This is owing to graphene possesses large specific surface area, unique electronic properties, unique physicochemical properties, high chemical and thermal stability. 27 Zhang et al have provided an easy approach to synthesize graphene nanosheets attached to spiky MnO 2 nanospheres which was applied in the detection of carcinoembryonic antigen. [19][20][21] In this regard, great efforts have been paid on the extension of nanostructure MnO 2 for other applications such as catalysis, sensors and so on.…”

Section: Introductionmentioning

confidence: 99%

A three dimensional Pt nanodendrite/graphene/MnO₂nanoflower modified electrode for the sensitive and selective detection of dopamine

et al. 2015

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An electrochemical sensor using novel three dimensional (3D) ternary Pt nanodendrites/reduce graphene oxide/MnO2 nanoflowers (Pt/RGO/MnO2) modified glassy carbon electrode was proposed for the selective and sensitive determination of dopamine (DA) in the presence of ascorbic acid (AA) and uric acid (UA). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to evaluate electrochemical behaviors of DA on the as-prepared electrode. The oxidation peak current of DA is linearly proportional to its concentration in the range from 1.5-215.56 μM, with a detection limit of 0.1 μM (at S/N=3). Compared to bare RGO, Pt nanodendrites/RGO and MnO2 nanoflowers modified electrodes, the 3D hierarchical ternary Pt/RGO/MnO2 composites displayed the highest electrocatalytic activity of the selective detection of DA. Moreover, the 3D Pt/RGO/MnO2 modified electrode can be reused with no obvious deterioration in the electrocatalytic performance. This work paves the way for developing a novel 3D nanostructure and offers new opportunities for improving the performance of electrochemical sensors with excellent sensitivity, repeatability and antiinterference.

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“…There can be a strongly synergistic interaction between Gr and its composite components, which can lead to enhanced catalytic activity and stability 9 . Various nanomaterials such as platinum nanoparticles with multi-walled carbon nanotubes 10 , graphene 11 and graphene oxide 12 have been introduced due to their ability for facilitating electron transfer of redox mediators, which leads to sensitive electrochemical aptasensors. Transition-metal dichalcogenides (TMDs) are atomically thin semiconductors of the type MX 2 , where M is a transition metal (Mo, W) and X is a chalcogen (S, Se, or Te).…”

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A sensitive electrochemical sensor for in vitro detection of parathyroid hormone based on a MoS2-graphene composite

Kim

Kulkarni

et al. 2016

Sci Rep

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This paper reports a biosensor based on a MoS2-graphene (MG) composite that can measure the parathyroid hormone (PTH) concentration in serum samples from patients. The interaction between PTH and MG was analysed via an electrochemical sensing technique. The MG was functionalized using l-cysteine. Following this, PTH could be covalently immobilized on the MG sensing electrode. The properties of MG were evaluated using scanning electron microscopy, high-resolution transmission electron microscopy, X-ray diffraction, Raman spectroscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectrometry. Following optimization of immobilized materials—such as MG, PTH, and alkaline phosphatase (ALP)—the performance of the MG sensor was investigated via cyclic voltammetry, to assess its linearity, repeatability, and reproducibility. Electrochemical impedance spectroscopy was performed on graphene oxide (GO) and MG-modified electrodes to confirm the capture of a monoclonal antibody (MAb) targeting PTH. Furthermore, the ALP-PTH-MG sensor exhibits a linear response towards PTH from artificial serum over a range of 1–50 pg mL−1. Moreover, patient sera (n = 30) were evaluated using the ALP-PTH-MG sensor and compared using standard equipment (Roche E 170). The P-value is less than 0.01 when evaluated with a t-test using Welch’s correction. This implies that the fabricated sensor can be deployed for medical diagnosis.

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A sensitive electrochemical aptasensor based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles and flower-like MnO₂ nanosphere functionalized multi-walled carbon nanotubes

Abstract: In this work, a sensitive electrochemical aptasensor for the detection of thrombin (TB) is developed and demonstrated based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles (PtNPs) and flower-like MnO2 nanosphere functionalized multi-walled carbon nanotubes (MWCNT-MnO2).

Cited by 68 publications

References 27 publications

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

A three dimensional Pt nanodendrite/graphene/MnO₂nanoflower modified electrode for the sensitive and selective detection of dopamine

A sensitive electrochemical sensor for in vitro detection of parathyroid hormone based on a MoS2-graphene composite

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A sensitive electrochemical aptasensor based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles and flower-like MnO2 nanosphere functionalized multi-walled carbon nanotubes

Abstract: In this work, a sensitive electrochemical aptasensor for the detection of thrombin (TB) is developed and demonstrated based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles (PtNPs) and flower-like MnO2 nanosphere functionalized multi-walled carbon nanotubes (MWCNT-MnO2).

Cited by 68 publications

References 27 publications

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

Biomimetic sensor based on molecularly imprinted polymer with nitroreductase-like activity for metronidazole detection

A three dimensional Pt nanodendrite/graphene/MnO2nanoflower modified electrode for the sensitive and selective detection of dopamine

A sensitive electrochemical sensor for in vitro detection of parathyroid hormone based on a MoS2-graphene composite

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A sensitive electrochemical aptasensor based on the co-catalysis of hemin/G-quadruplex, platinum nanoparticles and flower-like MnO₂ nanosphere functionalized multi-walled carbon nanotubes

A three dimensional Pt nanodendrite/graphene/MnO₂nanoflower modified electrode for the sensitive and selective detection of dopamine