A sensitive liquid chromatography–tandem mass spectrometry method for the quantification of mometasone furoate in human plasma

Sahasranaman, Srikumar; Tang, Yufei; Biniasz, Diana; Hochhaus, Günther

doi:10.1016/j.jchromb.2005.01.018

Cited by 20 publications

(10 citation statements)

References 15 publications

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“…The plasma concentrations of budesonide, beclometasone monopropionate (the active metabolite of beclometasone dipropionate), fluticasone propionate and mometasone furoate were determined using validated high‐performance liquid chromatography/tandem mass spectrometry methods with a Micromass Quattro LC‐Z triple quadrupole mass spectrometer (Beverley, MA, USA) at the College of Pharmacy, Department of Pharmaceutics, University of Florida, USA [9–12]. The lower limits of detection for the assays were 15 pg ml −1 for beclometasone monopropionate, fluticasone propionate and mometasone furoate and 50 pg ml −1 for budesonide.…”

Section: Methodsmentioning

confidence: 99%

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma

Mortimer

Harrison

Tang

et al. 2006

Brit J Clinical Pharma

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AimsTo compare the pharmacokinetic profiles of beclometasone, budesonide, fluticasone and mometasone following inhalation in patients with asthma, and explore the relationship between lung function and plasma drug concentrations. MethodsThirty subjects with asthma and a forced expiratory volume in 1 s (FEV 1 ) ranging from 36 to 138% predicted, inhaled 800 µ g beclometasone, budesonide and mometasone and 1000 µ g fluticasone in random order. Plasma drug concentrations were measured over 8 h and the relationship between the area under the plasma concentration-time curve (AUC 0 − 8 ) and lung function was modelled using linear regression. Estimated AUC 0 − 8 values at 50 and 100% predicted FEV 1 were compared for each drug. ResultsPharmacokinetic profiles differed markedly between the drugs. Correlation coefficients for the relation between FEV 1 % predicted and AUC 0 − 8 values for beclometasone, budesonide, fluticasone and mometasone were 0.37 ( P = 0.05), 0.33 ( P = 0.08), 0.25 ( P = 0.2) and 0.52 ( P = 0.004), respectively, and estimated AUC 0 − 8 values were 1.3 [95% confidence interval (CI) 1.0, 1.8], 1.3 (95% CI 1.0, 1.8), 1.4 (95% CI 0.9, 2.2) and 2.2 (95% CI 1.3, 3.5) times higher for the four drugs, respectively, at 100 compared with 50% predicted FEV 1. ConclusionThe higher plasma concentrations of inhaled corticosteroids in patients with a higher FEV 1 % predicted suggests that, for any given dose, these patients will be at greater risk of developing adverse systemic effects with long-term use.

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Section: Methodsmentioning

confidence: 99%

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma

Mortimer

Harrison

Tang

et al. 2006

Brit J Clinical Pharma

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“…Both the drugs are marketed as combined dose cream formulation in the ratio of 10:1 w/w TH: MF. Literature survey reveals that Terbinafine hydrochloride (TH) can be estimated by spectrophotometrically, HPTLC and HPLC individually or with other drugs in bulk drugs and in human plasma [1][2][3][4][5] while Mometasone furoate (MF) can be estimated by spectrophotometrically, HPLC and HPTLC in combination with other drugs [6][7][8][9][10] . However, there is no analytical method has been reported for the estimation of TH and MF in a combined dosage formulation.…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of HPTLC Method for Simultaneous Estimation of Terbinafine Hydrochloride and Mometasone Furoate in Combined Dosage Form

Patel

2016

J. Chil. Chem. Soc.

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A new simple, precise, accurate, specific and selective high performance thin layer chromatographic (HPTLC) method has been developed for the simultaneous estimation of Terbinafine hydrochloride (TH) and Mometasone furoate (MF) in cream dosage form. The chromatographic separation was achieved on Merck precoated silica gel aluminium plate 60 F254 using Toluene: Ethyl acetate: Glacial acetic acid (8: 4: 0.1 v/v) as mobile phase. The densitometric scanning was carried out at 248 nm. Response was found to be linear in the concentration range of 1000-3000 ng/band with correlation coefficient (r 2 = 0.999) for Terbinafine hydrochloride and 100-300 ng/band with correlation coefficient (r 2 = 0.998) for Mometasone furoate. All parameters of method, repeatability, precision, LOD, LOQ, % recovery were validated as per ICH guidelines. The proposed procedure was successfully applied for the simultaneous determination of both drugs in commercial cream preparation. The advantage of the method is simplicity, reasonable sensitivity, rapidity, excellent resolving power, low cost and is a more effective option than other chromatographic techniques in routine quality control.

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“…Literature survey revealed the determination of mometasone furoate (MF) in plasma by LC-tandem mass spectrometry (Sahasranaman et al, 2005), and by HPLC with stability studies (Teng et al, 2001). Also, MF was determined in its dosage form by HPLC (Ourique et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Forced degradation of mometasone furoate and development of two RP-HPLC methods for its determination with formoterol fumarate or salicylic acid

El‐Bagary

Fouad

El-Shal

et al. 2016

Arabian Journal of Chemistry

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Two simple, selective and precise stability-indicating reversed-phase liquid chromatographic methods were developed and validated for the determination of mometasone furoate in two binary mixtures, with formoterol fumarate (Mixture 1) and salicylic acid (Mixture 2). Also, a forced degradation study of mometasone furoate was carried out including acid and alkali hydrolysis, oxidation, thermal and photo-degradation. For mixture 1, the method was based on isocratic elution using a mobile phase consisting of (Acetonitrile: 3 mM Sodium lauryl sulfate) (60:40, v/v) at a flow rate of 1 ml min À1 . Quantitation was achieved applying dual wavelength detection where mometasone furoate and its degradation products were detected at 247 nm and formoterol fumarate and its degradation product were detected at 214 nm at 30°C. For mixture 2 and for the forced degradation study, separation was based on isocratic elution of mometasone furoate, its degradation products and salicylic acid on a reversed phase C8 column using a mobile phase consisting of acetonitrile:water:methanol:glacial acetic acid (60:30:10:0.1, v/v) at a flow rate of 2 mL min À1 . Quantitation was achieved with UV detection at 240 nm. In addition, products from alkaline forced degradation of mometasone furoate were verified by LC-MS. Linearity, accuracy and precision were found to be acceptable over the concentration range of 10-800 lg mL À1 and 5-60 lg mL À1 for mometasone furoate and formoterol fumarate, respectively and over the concentration range of 5-320 lg mL À1 and 20-1280 lg mL À1 for mometasone furoate and salicylic acid,

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A sensitive liquid chromatography–tandem mass spectrometry method for the quantification of mometasone furoate in human plasma

Cited by 20 publications

References 15 publications

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma

Plasma concentrations of inhaled corticosteroids in relation to airflow obstruction in asthma

Development and Validation of HPTLC Method for Simultaneous Estimation of Terbinafine Hydrochloride and Mometasone Furoate in Combined Dosage Form

Forced degradation of mometasone furoate and development of two RP-HPLC methods for its determination with formoterol fumarate or salicylic acid

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