A sensitive method for simultaneous determination of 12 classes of per- and polyfluoroalkyl substances (PFASs) in groundwater by ultrahigh performance liquid chromatography coupled with quadrupole orbitrap high resolution mass spectrometry

Liu, Siqi; Junaid, Muhammad; Zhong, Wei; Zhu, Youchang; Xu, Nan

doi:10.1016/j.chemosphere.2020.126327

Cited by 30 publications

(10 citation statements)

References 48 publications

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“…PFAS have been detected in groundwater from different sites worldwide due to multiple local or diffused contamination sources at levels above their limit of quantitation, a reference parameter that has progressively benefited from the introduction of technologies with higher sensitivity [154]. Among the different contamination pathways, the most severe impact derives from the environmental release of AFFFs used in firefight training facilities followed by the discharge of contaminated wastewater in effluents during PFAS manufacture activities.…”

Section: Pfas Occurrence In Ground Watermentioning

confidence: 99%

PFAS Molecules: A Major Concern for the Human Health and the Environment

Panieri

Baralić

Đukić-Ćosić

et al. 2022

Toxics

221

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Per- and polyfluoroalkyl substances (PFAS) are a group of over 4700 heterogeneous compounds with amphipathic properties and exceptional stability to chemical and thermal degradation. The unique properties of PFAS compounds has been exploited for almost 60 years and has largely contributed to their wide applicability over a vast range of industrial, professional and non-professional uses. However, increasing evidence indicate that these compounds represent also a serious concern for both wildlife and human health as a result of their ubiquitous distribution, their extreme persistence and their bioaccumulative potential. In light of the adverse effects that have been already documented in biota and human populations or that might occur in absence of prompt interventions, the competent authorities in matter of health and environment protection, the industries as well as scientists are cooperating to identify the most appropriate regulatory measures, substitution plans and remediation technologies to mitigate PFAS impacts. In this review, starting from PFAS chemistry, uses and environmental fate, we summarize the current knowledge on PFAS occurrence in different environmental media and their effects on living organisms, with a particular emphasis on humans. Also, we describe present and provisional legislative measures in the European Union framework strategy to regulate PFAS manufacture, import and use as well as some of the most promising treatment technologies designed to remediate PFAS contamination in different environmental compartments.

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Section: Pfas Occurrence In Ground Watermentioning

confidence: 99%

PFAS Molecules: A Major Concern for the Human Health and the Environment

Panieri

Baralić

Đukić-Ćosić

et al. 2022

Toxics

221

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“…30 For example, recent analysis of groundwater in China using HRMS has observed PFBA as one of the dominantly detected PFAS. 6 Another study utilizing MS/MS and HRMS observed high frequency of PFBA in seabird livers. 7 We hope this information will help to guide PFAS researchers in how to best verify PFBA quantification in biological matrices in the future to reduce potential over reporting of PFBA in the literature.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…3,4 The most investigated subclass of PFAS (often termed legacy PFAS) are the perfluoroalkyl acids (PFAAs). 5 Of the PFAAs, the two most studied to date are perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS); however, in recent decades, many applications of PFAS have transitioned to using shorter chain replacement PFAS, many of which have been quantified in both abiotic (e.g., drinking water) 6 and biotic matrices (e.g., plasma and tissue). 7 The investigation of PFAS in environmental and biological samples relies on both high-and low-resolution mass spectrometry (MS) techniques.…”

Section: ■ Introductionmentioning

confidence: 99%

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Bangma

Reiner

Fry

et al. 2021

Environ. Sci. Technol. Lett.

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The investigation of per- and polyfluorinated alkyl substances (PFAS) in environmental and biological samples relies on both high- and low-resolution mass spectrometry (MS) techniques. While high-resolution MS (HRMS) can be used for identification and quantification of novel compounds, low-resolution MS is the more commonly used and affordable approach for studies examining previously identified PFAS. Of note, perfluorobutanoic acid (PFBA) is one of the smaller PFAS observed in biological and environmental samples and has only one major MS/MS transition, preventing the use of qualitative transitions for verification. Recently, our laboratories undertook a targeted investigation of PFAS in the human placenta from high-risk pregnancies utilizing low-resolution, targeted MS/MS. Examination of placental samples revealed a widespread (n = 93/122 (76%)) chemical interferent in the quantitative ion channel for PFBA (213 → 169). PFBA concentrations were influenced by up to ∼3 ng/g. Therefore, additional chromatographic and HRMS/MS instrumentation was utilized to investigate the suspect peak and putatively assign the identity of the interfering compound as the saturated oxo-fatty acid (SOFA) 3-oxo-dodecanoic acid.

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“…Herbs have complex chemical systems involving various hydrophobic, hydrophilic, and amphiphilic molecules that feature a wide variety of acid-base properties, polarity, molecular mass, and content [( Luo et al, 2020 ), ( Wang et al, 2020 )], making it difficult to analyze their composition [( Feng et al, 2021 ), ( Ji et al, 2018 )]. In most previous studies, the systematic and comprehensive analysis of herb composition through liquid chromatography mass spectrometry had limited success due to limitations such as low precision and high detection limits [( Liu et al, 2020a )]. Fortunately, the ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) platform is a powerful tool for the comprehensive identification and analysis of ingredients in herbs due to its higher mass resolution, higher mass accuracy, wider dynamic range, and better sensitivity ( Liu et al, 2020b ; Xian et al, 2020 ; Yuan et al, 2020 ; Jia et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Revealing the Toxicity-Enhancing Essence of Glycyrrhiza on Genkwa Flos Based on Ultra-high-performance Liquid Chromatography Coupled With Quadrupole-Orbitrap High-Resolution Mass Spectrometry and Self-Assembled Supramolecular Technology

Yang

Yan

et al. 2021

Front. Chem.

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Researchers often focus on the mechanisms of synergistic agents, a few explore drug combinations that enhance toxicity, while few have studied the internal mechanism of compatibility enhancement in chemical level. Herein, we present a comprehensive analysis based on ultra-high-performance liquid chromatography coupled with quadrupole-Orbitrap high-resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) and a self-assembled supramolecular strategy, which reveals the toxicity-enhancing essence of glycyrrhizic acid originated in licorice when combined with Genkwa Flos. Through this method, we discovered the toxicity was enhanced through the formation of a supramolecular complex from Genkwa Flos/glycyrrhizic acid. The morphology and size distribution of the self-assembled nanoparticles were characterized by scanning electron microscopy and dynamic light scattering Furthermore, a total of 58 constituents (eight diterpenoids, 35 flavonoids, five phenylpropanoids, four nucleosides, two amino acids, and four other compounds) consisted from the supramolecular complex were identified through accurate-mass measurements in full-scan MS/data-dependent MS/MS mode. Based on the hydrophobic interaction of glycyrrhizic acid with yuanhuacine (one of main ingredients from Genkwa Flos), the supramolecular self-assembly mechanism was revealed with proton nuclear magnetic resonance (1H-NMR) and NOESY 2D NMR. The toxicity of Genkwa Flos and Genkwa Flos/glycyrrhizic acid supramolecular complex were compared through in vitro studies on L-02 cells using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; and 4′,6-diamidino-2-phenylindole (DAPI) staining was performed to further confirm the enhancement inhibition of Genkwa Flos/glycyrrhizic acid supramolecular complex than Genkwa Flos. This study provides fundamental scientific evidence of the formation of a self-assembled phytochemical supramolecular when Genkwa Flos and glycyrrhizic acid are combined, enabling to understand their clinical incompatibility and contraindication.

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A sensitive method for simultaneous determination of 12 classes of per- and polyfluoroalkyl substances (PFASs) in groundwater by ultrahigh performance liquid chromatography coupled with quadrupole orbitrap high resolution mass spectrometry

Cited by 30 publications

References 48 publications

PFAS Molecules: A Major Concern for the Human Health and the Environment

PFAS Molecules: A Major Concern for the Human Health and the Environment

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Revealing the Toxicity-Enhancing Essence of Glycyrrhiza on Genkwa Flos Based on Ultra-high-performance Liquid Chromatography Coupled With Quadrupole-Orbitrap High-Resolution Mass Spectrometry and Self-Assembled Supramolecular Technology

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