A sensitive nanocomposite design via carbon nanotube and silver nanoparticles: Selective probing of Emedastine Difumarate

Imanzadeh, Hamideh; Bakırhan, Nurgul K.; Habibi, Biuck; Özkan, Síbel A.

doi:10.1016/j.jpba.2020.113096

Cited by 12 publications

References 19 publications

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Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids

et al. 2020

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A cobalt oxide nanoparticles (Co3O4NPs) and multi walled carbon nanotubes (MWCNTs) modified carbon paste electrodes were used to study the electrochemical behavior of linagliptin and empagliflozin in Britton Robinson buffer solution of pH 8.0 using cyclic and square wave voltammetry. The above mentioned modified electrodes showed highly sensitive sensing and gave an excellent anodic response for both drugs. The peak current varied linearly over the concentration ranges: 3.98×10−5–1.53×10−3 mol L−1 (18.82–723.00 μg/mL) and 7.94×10−6–1.07×10−4 mol L−1 (3.65–48.25 μg/mL) with determination coefficients of 0.9999 and 0.9998 for linagliptin and empagliflozin, respectively. The recoveries and relative standard deviations were found in the following ranges: 98.80 %–102.00 % and 0.23 %–1.90 % for linagliptin and 98.30 %–101.80 % and 0.11 %–1.86 % for empagliflozin. The detection and quantification limits were 1.13×10−5 and 3.76×10−5 mol L−1 (5.34and17.77 μg/mL) for linagliptin, 1.71×10−6and 5.68×10−6 mol L−1 (0.77 and 2.56 μg/mL) for empagliflozin. The proposed sensors have been successfully applied for the determination of the drugs in bulk, pharmaceutical formulations and biological fluids.

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Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids

et al. 2020

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A Chemometric–Assisted Voltammetric Method for Simultaneous Determination of Acetaminophen and Diclofenac

Azish,

Pourbasheer,

Imanzadeh

et al. 2024

ChemistrySelect

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Diclofenac (DCF) and Acetaminophen (ACT) are among the most important nonsteroidal anti–inflammatory drugs (NSAIDs) that sought after for their antipyretic, analgesic, and anti‐inflammatory properties. In addition, ACT and DCF show synergistic activity toward pain relief. Therefore, appropriate analytical strategies are required for the simultaneous quantification of these NSAIDs in prescription drugs. This study introduces a method for the direct and simultaneous determination of ACT and DCF using the voltammetric approach in conjunction with chemometric tools such as partial least squares (PLS) and genetic algorithm–multiple linear regressions (GA−MLR). The calibration set was established using differential pulse voltammetry for 25 distinct mixtures of ACT and DCF. The calibration curve exhibited linearity within the concentration ranges of 0.1–1000 μM for ACT and 0.1–100 and 100–1000 for DCF. The effectiveness of chemometric methods was evaluated by analyzing synthetic mixtures of ACT and DCF and applying these methods to real samples containing a commercial pharmaceutical preparation of the specified drugs. Both methods yielded favorable results.

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Inorganic Complexes and Metal-Based for Biomarkers Sensors

Carvalho

Soares

Alves

et al. 2022

Advances in Bioelectrochemistry Volume 5

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A sensitive nanocomposite design via carbon nanotube and silver nanoparticles: Selective probing of Emedastine Difumarate

Cited by 12 publications

References 19 publications

Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids

Validated Voltammetric Method for the Simultaneous Determination of Anti‐diabetic Drugs, Linagliptin and Empagliflozin in Bulk, Pharmaceutical Dosage Forms and Biological Fluids

A Chemometric–Assisted Voltammetric Method for Simultaneous Determination of Acetaminophen and Diclofenac

Inorganic Complexes and Metal-Based for Biomarkers Sensors

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