A Sensitive SERS Quantitative Analysis Method for Amino Acids Using Ruhemann’s Purple as Molecular Probe in Triangle Nanosilver Sol Substrate

Luo, Yanghe; Wen, Guiqing; Ma, Lu; Liang, Aihui

doi:10.1007/s11468-016-0264-8

Cited by 12 publications

(5 citation statements)

References 26 publications

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“…The signal reproducibility from sample-to-sample was assessed by the EF from substrate to substrate. For almost all the substrates, the average gain was 1•10 5 and was found to be well reproducible (figure 4(a)).…”

Section: Resultsmentioning

confidence: 87%

“…Surface-enhanced Raman spectroscopy (SERS) is a modern analytical method to determine trace amounts of a wide variety of high and low molecular weight compounds such as polycyclic aromatic hydrocarbons [1], polycyclic aromatic sulfur heterocycles [2], phenolic compounds [3] amino acids [4,5] and proteins [6]. The advantage of this technique is based on the possibility of obtaining bright molecular fingerprint spectra at remarkably low concentrations of analytes.…”

Section: Introductionmentioning

confidence: 99%

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Plasmonic features of free-standing chitosan nanocomposite film with silver and graphene oxide for SERS applications

Samodelova¹,

Kapitanova²,

Евдокимов³

et al. 2022

Nanotechnology

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A scalable procedure of SERS substrates design was developed using a novel plasmonic structure based on a freestanding chitosan film, silver nanoparticles, and graphene oxide. Chitosan provides a uniform distribution of silver nanoparticles from a colloidal suspension and, therefore, a reproducible Raman signal from local areas of measurements of several tens of microns. The addition of graphene oxide (GO) to the colloidal solution of silver nanoparticles suppresses the tortuous background fluorescence signal from the analyte and leads to an increase in the signal-to-fluorescence background intensity ratio by up to 6 times as compared to structures without GO. The manufactured plasmonic polymer nanocomposite provides a detection limit of down to 100 pM for R6G using a laser wavelength of 532 nm through a portable ×10 objective. The high colloidal stability of GO in water and the use of an aqueous colloid of silver nanoparticles simplify the procedure for creating a substrate by applying the GO-silver composite on the surface of a chitosan film without a need to form a GO film. Therefore, our approach paves a promising avenue to provide more sensitive detection even for the fluorescent analytes with short-wavelength lasers (532, 633 nm) instead of IR (785, 1024 nm) and foster the practical application of the developed plasmonic composites on portable Raman spectrometers.

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Section: Resultsmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Plasmonic features of free-standing chitosan nanocomposite film with silver and graphene oxide for SERS applications

Samodelova¹,

Kapitanova²,

Евдокимов³

et al. 2022

Nanotechnology

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“…Ruhemann's purple was first synthesized and figured out by Siegfried Ruhemann in 1910 [12] . Among RP applications, using it as a molecular probe to identify amino acids and in the field of radiation dosimetry can be mentioned [19,20] . On the other hand, the stability of RP pigments has been observed via the condensation of ninhydrin/amino acids with transition metal ions [14] .…”

Section: Introductionmentioning

confidence: 99%

“…[12] Among RP applications, using it as a molecular probe to identify amino acids and in the field of radiation dosimetry can be mentioned. [19,20] On the other hand, the stability of RP pigments has been observed via the condensation of ninhydrin/amino acids with transition metal ions. [14] The widespread use of ninhydrin-based Schiff bases as anti-cancer, antibacterial, antibiotic, anti-inflammatory agents, and anti-fungal has received a lot of attention due to their high physiological activity.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Chitosan Hydrogels Containing Ruhemann's Purple and Zn(II) Complex of Ninhydrin with Antibacterial and Antioxidant and Photodynamic Therapy Properties

2023

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In this study, homogeneous hydrogels based on chitosan containing ninhydrin derivatives, including Ruhemann's purple (RP) and its Zn(II) Schiff base chelate of indane-l,3-dione-2imine-N-acetic acid (Zn(II)IDIA), as photosensitizers have been synthesized with the potential of photodynamic therapy (PDT) applications. Ninhydrin is a valuable organic compound that exhibits bacteriostatic, virucidal, and anti-diabetogenic properties. This study describes how the use of ninhydrin is a viable option for the investigation of in vitro PDT activities. The hydrogels were prepared through chemical cross-linking using glutaraldehyde and loaded with water-soluble photosensitizers. According to the results, the hydrogels demonstrated a threedimensional (3D) porous morphology, remarkable singlet oxygen generation, antibacterial activity, and good mechanical strength. The results of the cell viability assay illustrated their excellent biocompatibility and safety. All the information in this study supports the capability of the hydrogels containing RP and Zn(II)IDIA for PDT treatment.

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“…Plasmonic nanostructures have attracted much attention in biomedical field due to their interesting optical properties [1][2][3][4][5][6][7][8][9]. Recently, by using the localized surface plasmon resonances (LSPRs) which can concentrate light into subwavelength volumes and are highly tunable by the geometry of nanostructures [10,11], various plasmonic nanoparticle based optical tags have been proposed and play important role in biomedical imaging and biomarker detection [3][4][5][6][7][8][9]. Compared with conventional fluorescence tags based on organic dyes [12][13][14], plasmonic nanoparticle tags offer several advantages, such as high biocompatibility, tunability and photochemical stability.…”

Section: Introductionmentioning

confidence: 99%

Generation of unconventional Fano-comb resonances in multilayered core–shell nanoparticles

Li¹,

Zhong

Ding

et al. 2019

Nanotechnology

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We theoretically propose a design of core–shell nanoparticles consisting of a dielectric core coated by several alternating plasmonic and dielectric shell layers for the generation of comb-like scattering resonances. We demonstrate that the obtained scattering resonances are independent of the polarization, observation angle and background medium, since they originate from the unconventional Fano interference between Mie modes with the same multipole moment inside each plasmonic shell layer. Furthermore, we also demonstrate that controlling either the core or the shell parameters can precisely tune the spectral positions of the comb-like resonances. At last, we show that the comb-like resonances can be well maintained even for the non-perfect spherical core–shell nanoparticles. All these features make the proposed multilayered core–shell nanoparticles attractive candidates for multichannel and ultrasensitive optical tags.

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A Sensitive SERS Quantitative Analysis Method for Amino Acids Using Ruhemann’s Purple as Molecular Probe in Triangle Nanosilver Sol Substrate

Cited by 12 publications

References 26 publications

Plasmonic features of free-standing chitosan nanocomposite film with silver and graphene oxide for SERS applications

Plasmonic features of free-standing chitosan nanocomposite film with silver and graphene oxide for SERS applications

Preparation of Chitosan Hydrogels Containing Ruhemann's Purple and Zn(II) Complex of Ninhydrin with Antibacterial and Antioxidant and Photodynamic Therapy Properties

Generation of unconventional Fano-comb resonances in multilayered core–shell nanoparticles

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