A Series of Six Cases of Candida Ciferrii Infection in a Tertiary Care Centre of North India

Abstract

Aim:We aim to understand the role of Candida ciferrii (C. ciferrii) as a pathogen for invasive mycosis. Presentation of Cases: We report six cases of patients with invasive disease due to C. ciferrii from a tertiary care centre of North India in one year. Among the six cases, two cases are of candidemia, three from lower respiratory samples and one from drainage fluid. Discussion: Fungal infections especially candidiasis may occur in immunocompromised patients or in patients with associated co-morbidities. Candidiasis increases both the morbidity and mortality. C. ciferrii has been rarely reported as cause of human infection. It may not be the primary pathogen but has the potential to exacerbate the existing pathology. Conclusion:Rare and unusual pathogens should not be ignored. They should be reviewed in accordance with the patient's clinical manifestations and treated promptly to improve the prognosis of patient in appropriate clinical conditions.

Genome Assemblies of Two Rare Opportunistic Yeast Pathogens:Diutina rugosa(syn.Candida rugosa) andTrichomonascus ciferrii(syn.Candida ciferrii)

“…Indeed, in a 10-year multi-center study a 10-fold increase in the number of D. rugosa clinical cases was reported (Pfaller et al 2010). T. ciferrii has also been reported as an opportunistic pathogen in some sporadic cases of infections in immunocompromised patients (Gunsilius et al 2001; Pfaller et al 2010; Saha et al 2013; Villanueva-Lozano et al 2016; Upadhyay et al 2018). Both species were recently shown to present high MICs to azoles and echinocandins (Pfaller et al 2006; Pérez-Hansen et al 2019).…”

A rare case of blood stream infection due to Candida ciferii in an immuno-compromised patient

“…These two cases were managed with caspofungin and all cases had an uneventful recovery. 10 Hiram Villanueva-Lozano reported an unusual case of C. ciferrii fungemia in an immune-compromised patient with Crohn's and Mycobacterium bovis disease. In this case, fluconazole MIC = 32 μg/ml and the patient did not respond clinically.…”

Antifungal Resistance of Candida Species in Bacolod City, Philippines

“…With the current available literatures, C. ciferrii is rarely isolated or an infrequent type of Candida species that is known to cause superficial pathogenicity [29][30][31]. Some papers have documented that C. ciferrii was able to cause blood stream infections [29][30][31], pulmonary infections [30,32], gangrenous infections [30], onchomycosis [33] and urinary tract infections [14]. Similarities among these infected patients include co-morbidities such as COPD, age, diabetes, malnutrition, malignancy, other chronic diseases, and immunosuppression [31,32].…”