A serious complicatıon of liver hydatid cysts in children: cystobiliary fistulas

Demir, Sabri̇; Ilikan, Gülşah Bayram; Ertürk, Ahmet; Öztorun, Can İhsan; Güney, Doğuş; Azılı, Müjdem Nur; Şenel, Emrah; Tiryaki, Tuğrul

doi:10.1007/s00383-020-04637-9

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…This technique, which can be used in children as young as three years of age, can be performed in the following local conditions: non-echoic lesion ≥5 cm in diameter (CE1m and l), cysts with daughter cysts (CE2) and/or with the detachment of membranes (CE3), multiple cysts if accessible to puncture, and infected cysts (the WHO Informal Working Group on Echinococcosis (WHO-IWGE) classified liver hydatid cysts as CE1, CE2, CE3a, CE3b, CE4, and CE5, which corresponds to Gharbi et al [ 24 ]). In this procedure, the cyst is punctured percutaneously (it should be located at least 2 cm below the surface of the liver, and there must be no cystic-biliary fistula [ 23 , 44 ]). Part of the cyst fluid is aspirated.…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

“…The disadvantage of this method is, on the one hand, that the tumor capsule remains in situ and, on the other hand, that the cyst capsule can be damaged. It means that protoscolices can be spread intraperitoneally, which in turn can cause a severe allergic reaction [ 44 , 45 ]. In the case of huge cysts, a cystic-biliary fistula is also possible due to intervention [ 23 , 40 , 44 ].…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

“…It means that protoscolices can be spread intraperitoneally, which in turn can cause a severe allergic reaction [ 44 , 45 ]. In the case of huge cysts, a cystic-biliary fistula is also possible due to intervention [ 23 , 40 , 44 ]. Whether the PAIR procedure is sufficient as a sole intervention has not yet been proven, especially since there is a risk that the residual cavity can become secondarily infected.…”

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

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Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Hager

Sergi

2023

Diagnostics

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Echinococcosis is considered a neglected disease in most European countries. However, migratory flows of populations, long-term stays in endemic areas, uninterrupted tourism (travel to Echinococcus-endemic countries), traveling dogs and dog translocations from endemic areas, and inappropriate hygiene practices are potential factors that alarm public health officials. Identifying a cyst-like mass in the liver or lung of an individual with a travel history of likely exposure to sheepdogs in an area where the parasite Echinococcus (E.) granulosus (sive cysticus) is endemic advocates for a prompt preliminary diagnosis of cystic echinococcosis (CE), no matter the age of the affected individuals. Routine imaging techniques, including ultrasonography, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans, are used to detect cysts. After a cyst has been discovered, serologic investigations are used to confirm the diagnosis. Typically, alveolar echinococcosis (AE) is found in older individuals. Yet young people are also affected because frequent oral exploration of the environment is a regular behavior for infants and toddlers. In this review, therapeutic considerations for pediatric echinococcosis—drug-based benzimidazole therapy; AE: atypical liver resection, the resection of individual or multiple segments, a right or left hemi-hepatectomy, or an extended hemi-hepatectomy; CE: PAIR-technique, cyst excision, liver segment(s) resection (laparoscopically or conventionally)—are revised following experience in one of the most affected regions of Europe. In addition, we performed a systematic review using three databases (i.e., PubMed, EMBASE, and Scopus) to evaluate the quality of evidence in published studies on pediatric echinococcosis.

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Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

Section: Discussion With Therapy Guidelinesmentioning

confidence: 99%

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Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Hager

Sergi

2023

Diagnostics

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“…In Northwest China, especially in large pastoral areas (such as Xinjiang and Tibet), children are infected with cystic echinococcosis at a high prevalence, seriously endangering their health. Large hydatid cysts are common in the detection of hydatidosis in children, and the complication rate of cyst rupture is higher than in adults [ 2 , 3 ]. At present, the regulation mechanism of Echinococcus multilocularis (E. multilocularis) eggs forming cysts in a human host after infection is unclear.…”

Section: Introductionmentioning

confidence: 99%

The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

Qin¹,

Guo²,

Li³

et al. 2022

BMC Mol and Cell Biol

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Objective The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with the cyst formation of hepatic Echinococcus granulosus in young children. Methods A total of 40 patients who met the diagnostic criteria for children's hydatid disease in people's Hospital of Xinjiang Uygur Autonomous Region between January 2020 and June 2021 were enrolled a s the study subjects. The cystic fluid of these children was collected as the case group and the corresponding infected viscera or pericystic tissue as the control group, with 40 cases in each group. In vitro cultured protoscolice of hydatid cyst, four groups including control group, LIF siRNA group, LIF factor group and SMAD4 siRNA group were divided by inhibiting TGF-β/SMADs signal pathway. Each assay was performed in triplicate. The expression of TGF-β, SMAD2/3/4 and LIF were detected. Results The results of the clinical trial showed that the contents of SMAD2 and SMAD3 were increased in the case group compared with the control group; the differences were statistically significant (P < 0.05). The expression levels of TGF-β, Smad4, and LIF increased in the case group compared with the control group; however, the differences were not statistically significant. The results of further in vitro experiments, the expression levels of TGF-β, SMAD 2/3/4, and LIF after adding siRNA to interfere with Smad4 decreased in the case group compared with the control group; the differences were statistically significant (P < 0.05). Compared with the control group, the expression levels of TGF-β, SMAD2/3/4, and LIF increased after treatment with added LIF in the case group, and the expression levels of TGF-β, SMAD2/3/4, and LIF decreased after adding siRNA to interfere with LIF in the case group; the differences were all statistically significant (P < 0.05). Conclusion SMAD2 and SMAD3 have a certain clinical relevance with hydatidosis in young children. The LIF expression level may be related to the cystic transformation of protoscoleces. It has been suggested that the TGF-β/Smads/LIF signaling pathway may be present in the process of protoscoleces cyst formation; this provides a research basis for the prevention and treatment of post-infection parasitism of E. multilocularis eggs in young children.

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Echinococcosis

Tamarozzi

Manciulli

Brunetti

et al. 2022

Helminth Infections and Their Impact on Global Public Health

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A serious complicatıon of liver hydatid cysts in children: cystobiliary fistulas

Cited by 6 publications

References 16 publications

Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

Pediatric Echinococcosis of the Liver in Austria: Clinical and Therapeutical Considerations

The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children

Echinococcosis

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