A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study

Tu, Huakang; Sun, Liping; Dong, Xiao; Gong, Yuehua; Xu, Qian; Jing, Jingjing; Bostick, Roberd M.; Wu, Xifeng; Yuan, Yuan

doi:10.1038/ajg.2017.55

Cited by 99 publications

(132 citation statements)

References 41 publications

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“…Combined detection of serum pepsinogen I and II, H. pylori antibody, and gastrin‐17 (known as a “serology biopsy”) has proved useful in screening for gastric mucosal atrophy, a high‐risk group of gastric cancer. Non‐invasive serological screening combined with endoscopy can help improve the effect of gastric cancer screening . A total of 14 929 serum samples and endoscopic data from China showed that age, sex, pepsin ratio < 3.89, gastrin‐17 > 1.50 pmol/L, H. pylori antibody positive, salted food, and fried food are the seven high‐risk factors for gastric cancer .…”

Section: Helicobacter Pylori Screening and Eradication Strategymentioning

confidence: 99%

“…Non-invasive serological screening combined with endoscopy can help improve the effect of gastric cancer screening. 41 A total of 14 929 serum samples and endoscopic data from China showed that age, sex, pepsin ratio < 3.89, gastrin-17 > 1.50 pmol/L, H. pylori antibody positive, salted food, and fried food are the seven high-risk factors for gastric cancer. 42 The gastric cancer risk score scale was developed based on these factors and has been used for the screening of populations at high risk for gastric cancer in China.…”

Section: Y Du Et Almentioning

confidence: 99%

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Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Liu

et al. 2020

J of Gastro and Hepatol

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Background and Aim China is a country with high prevalence of Helicobacter pylori (H. pylori) infection, which in turn is closely related to the occurrence of gastric cancer. Therefore, the risks of H. pylori infection and gastric cancer are highly overlapping, and the prevention and treatment of H. pylori infection are necessary to prevent gastric cancer. Methods Based on evidence‐based medicine and the Delphi method, the National Clinical Medical Research Center for Digestive Disease along with the National Early Gastrointestinal Cancer Prevention and Treatment Center Alliance organized dozens of experts in the fields of digestive diseases, H. pylori research, gastric cancer surgery, epidemiology, health economics, and health management to discuss the relationship between H. pylori eradication and prevention and the treatment of gastric cancer. Results A preliminary consensus on the relationship between H. pylori infection and gastric cancer, H. pylori eradication and gastric cancer prevention, and H. pylori screening and eradication strategy was reached. The consensus further clarified the relationship between H. pylori and gastric cancer and how to formulate future prevention and control strategies for gastric cancer. Conclusions This consensus could provide guidance on early detection, diagnosis, and treatment of H. pylori to reduce the occurrence of gastric cancer in China.

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Section: Helicobacter Pylori Screening and Eradication Strategymentioning

confidence: 99%

Section: Y Du Et Almentioning

confidence: 99%

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Liu

et al. 2020

J of Gastro and Hepatol

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“…[19][20][21][22] No investigation has referred to an association between either EBV serology and GC prognosis or EBV and serum gastric function indicators such as pepsinogen I (PGI), pepsinogen II (PGII), pepsinogen I/II (PGI/II), and gastrin-17 (G-17), which could reflect the functional status of gastric mucosa and were thus recognized as indicators for the early detection of GC. 23 In addition, it remains unclear whether the EBV serologic assay has the potential to be a biomarker for GC prediction and prognosis.…”

Section: Introductionmentioning

confidence: 99%

Role of serum EBV‐VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population

Wang

Ding

et al. 2018

Cancer Medicine

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The study aimed to investigate the role of serum EBV‐VCA IgG in assessing gastric cancer (GC) risk and prognosis. A total of 1790 Northern Chinese participants with pathologically confirmed disease underwent EBV‐VCA IgG serologic testing using enzyme‐linked immunosorbent assay (ELISA), including 821 controls, 410 atrophic gastritis (AG) patients, and 559 GC patients. We found that positive EBV‐VCA IgG was significantly associated with GC and its precursor, conferring a 1.55‐ and 1.36‐fold increased risk of GC and AG, respectively (P = 0.001, 95% CI = 1.21‐1.99; P = 0.011, 95% CI = 1.07‐1.72, respectively). The risk effects were more remarkable in younger, female, and Helicobacter pylori‐negative individuals than in older, male, and H. pylori‐positive individuals. EBV‐VCA IgG‐positive subjects had a lower PGI/II ratio than EBV‐VCA IgG‐negative subjects (median 8.0 vs 8.8, P = 0.001), especially those in the H. pylori‐positive (median 6.1 vs 6.8, P = 0.027) and GC subgroups (median 6.4 vs 7.9, P = 0.020). In the intestinal GC subgroup, the survival of EBV‐VCA IgG‐positive patients was worse than that of EBV‐VCA IgG‐negative patients (P = 0.041, HR = 2.45, 95% CI = 1.04‐5.78). Our study suggests that EBV‐VCA IgG seropositivity has potential in predicting the risk of GC and its precursor as well as the prognosis of histologically classified GC.

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“…Based on this, the ABCD screening method was used in Japan as gastric cancer risk stratification for developing appropriate inspection strategies. [164][165][166][167][168] A recent study in China 169 showed that the combined detection of PG, gastrin-17, and anti-H. pylori antibody could stratify the risk of gastric cancer and identify highrisk patients for gastroscopy. The PG I/II ratio was negatively correlated with OLGA staging.…”

Section: Statement 45mentioning

confidence: 99%

Chinese consensus on chronic gastritis (2017, Shanghai)

Fang¹,

Du²,

Liu³

et al. 2018

J of Digest Diseases

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A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study

Abstract: A serological biopsy composed of the five stomach-specific circulating biomarkers could be used to identify high-risk individuals for further diagnostic gastroscopy, and to stratify individuals' risk of developing GC and thus to guide targeted screening and precision prevention.

Cited by 99 publications

References 41 publications

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Consensus on eradication of Helicobacter pylori and prevention and control of gastric cancer in China (2019, Shanghai)

Role of serum EBV‐VCA IgG detection in assessing gastric cancer risk and prognosis in Northern Chinese population

Chinese consensus on chronic gastritis (2017, Shanghai)

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