A serotonin-modified hyaluronic acid hydrogel for multifunctional hemostatic adhesives inspired by a platelet coagulation mediator

An, Soohwan; Jeon, Eun Je; Jeon, Jonggu; Cho, Seung Woo

doi:10.1039/c9mh00157c

Cited by 91 publications

(79 citation statements)

References 46 publications

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“…[1][2][3][4] However, achieving strong underwater adhesion is challenging due to the difficulty in displacing hydrated water from adhesive interface. [1][2][3][4] However, achieving strong underwater adhesion is challenging due to the difficulty in displacing hydrated water from adhesive interface.…”

Section: Despite Recent Advance In Bioinspired Adhesives Achieving Smentioning

confidence: 99%

“…Recently, host-guest chemistry strategy was reportedly employed to prepare underwater adhesives; however, the substrate surface needs to be modified in advance. However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. [13,14] In nature, many organisms, such as mussels, barnacles, and castle worms, have evolved an unparalleled mechanism to perfectly tackle the underwater adhesion problem.…”

mentioning

confidence: 99%

“…However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. [1][2][3][4] However, achieving strong underwater adhesion is challenging due to the difficulty in displacing hydrated water from adhesive interface. [13] In this process, phase separation and concurrently increased hydrophobicity induced by coacervation can dispel the hydrated water on the interface, leading to much enhanced interaction of adhesive groups with the adherent and thus stable underwater adhesion.…”

mentioning

confidence: 99%

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Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

et al. 2019

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is greatly decreased or even eliminated. For instance, the widely used cyanoacrylate adhesives exhibit strong adhesion in air, but when applied in water environment, they are hardened quickly to form a layer of stiff plastics, eventually resulting in the loss of adhesion. [9] The commercially available epoxy resins [10] and polyurethanes [11] are reported to demonstrate strong underwater adhesion, but long time of curing is usually required. Recently, host-guest chemistry strategy was reportedly employed to prepare underwater adhesives; however, the substrate surface needs to be modified in advance. [5,12] In addition, electrostatic and hydrophobic interactions were also proved to contribute to enhanced underwater adhesion, but the adhesion strength was relatively poor. [13,14] In nature, many organisms, such as mussels, barnacles, and castle worms, have evolved an unparalleled mechanism to perfectly tackle the underwater adhesion problem. [15][16][17] The finding of universality of catechol chemistry for wet adhesion has provided a valuable biomimetic source to develop diverse adhesives for use in aqueous environments. However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. Although numerous dopamine-based adhesives have been reported and shown to bond various material surfaces, strong adhesion in water and particularly blood environment, remains nonexistent so far.Increasing studies on bioadhesives secreted by molluscs and insects have suggested that liquid coacervation plays a critical role in achieving underwater adhesion. [13] In this process, phase separation and concurrently increased hydrophobicity induced by coacervation can dispel the hydrated water on the interface, leading to much enhanced interaction of adhesive groups with the adherent and thus stable underwater adhesion. Up to date, several complex coacervate adhesives with linear structure have been reported, but the occurrence of those coacervations in water needs external triggers, such as temperature, [13] pH, [20,23] and iron strength. [24] Compared to linear counterparts, hyperbranched polymer (HBP) has a unique highly branched Despite recent advance in bioinspired adhesives, achieving strong adhesion and sealing hemostasis in aqueous and blood environments is challenging. A hyperbranched polymer (HBP) with a hydrophobic backbone and hydrophilic adhesive catechol side branches is designed and synthesized based on Michael addition reaction of multi-vinyl monomers with dopamine.It is demonstrated that upon contacting water, the hydrophobic chains selfaggregate to form coacervates quickly, displacing water molecules on the adherent surface to trigger increased exposure of catechol groups and thus rapidly strong adhesion to diverse materials from low surface energy to high energy in various environments, such as deionized water, sea ...

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Section: Despite Recent Advance In Bioinspired Adhesives Achieving Smentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

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“…Additionally, it may lead to a standardization on the choice of the most appropriate HA among surgeons. In a futurist perspective, the current investigations on HAs have been focusing on chemical modifications on the biopolymers backbone to improve the blood absorption rate, hemostatic activity, among other characteristics of HAs (An, Jeon, Jeon, & Cho, 2019; Logun et al, 2019; Zhao et al, 2019).…”

Section: Does the Use Of Has Offers Significant Advantages In Lpn Pramentioning

confidence: 99%

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

et al. 2020

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In recent years, there was an abrupt increase in the incidence of renal tumors, which prompt up the appearance of cutting-edge technology, including minimally invasive and organ-preserving approaches, such as laparoscopic partial nephrectomy (LPN). LPN is an innovative technique used to treat small renal masses that have been gaining popularity in the last few decades due to its promissory results. However, the bleeding control remains the main challenge since the majority of currently available hemostatic agents (HAs) used in other surgical specialities are inefficient in LPN. This hurried the search for effective HAs adapted for LPN surgical peculiarities, which resulted on the emergence of different types of topical HAs. The most promising are the natural origin HAs because of their inherent biodegradability, biocompatibility, and lowest toxicity. These properties turn them top interests' candidates as HAs in LPN. In this review, we present a deep overview on the progress achieved in the design of HAs based on natural origin polymers, highlighting their distinguishable characteristics and providing a clear understanding of their hemostat's role in LPN. This way it may be possible to establish a structure-composition properties relation, so that novel HAs for LPN can be designed to explore current unmet medical needs. K E Y W O R D S biodegradable hemostatic agents, hemostasis, laparoscopic partial nephrectomy, minimally invasive surgeries, renal cell carcinoma 1 | BACKGROUND Kidney cancer is a serious condition, in accordance with the International Agency for Research on Cancer (IARC) it is the 16th most common cause of cancer death and the prevalence has been increasing every year, making kidney cancer considered as a clinically signifi

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“…[ 1‐4 ] Wound healing is a complex process consisting of four overlapping phases that involve hemostasis, inflammation, proliferation, and tissue remodeling. [ 5‐7 ] Various materials are currently employed as dressings for wound treatment, including gauze, biocompatible membranes, porous foams, and hydrogels. [ 8‐11 ] Currently available dressings protect the wound from further damage and contamination, alleviate pain, absorb exudates, maintain a moist environment, and permit oxygen permeation.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing

Zhang

Tian

Chen

et al. 2020

Advanced Therapeutics

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Multifunctional dressings are attracting increased interest in the area of tissue engineering and regenerative medicine. Wound healing is a dynamic and complex process that requires multidisciplinary management. However, dressings that exhibit both anti‐infective and tissue regenerative properties are still limited. Herein, a hydrogel‐based multifunctional dressing weaved by drug‐loaded magnetothermally responsive [Fe3O4@SiO2‐interpenetrating polymer network (IPN)] microfibers and human umbilical cord mesenchymal stem cell‐laden microfibers is developed. Magnetothermally responsive microfibers, as smart constructs, can release antibiotics on‐demand to prevent infection, due to the magnetothermal heating effect of the embedded magnetic nanoparticles and the thermoresponsive property of the IPN hydrogels. Furthermore, stem cell‐laden microfibers markedly promote cell proliferation and tissue remodeling, with improved re‐epithelization, granulation tissue formation, and collagen deposition at the wound site. Hydrogel‐based microfibers have the additional ability of absorbing exudate, providing a moist environment, and retaining the therapeutic cells. Therefore, functional microfibers and textiles significantly accelerate the healing process. An advanced dressing for wound healing, incorporating controlled drug delivery and stem cell‐based therapy is developed. Furthermore, the results of the present study reveal the potential of multifunctional dressings in tissue engineering and regenerative medicine.

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A serotonin-modified hyaluronic acid hydrogel for multifunctional hemostatic adhesives inspired by a platelet coagulation mediator

Abstract: Serotonin-conjugated hyaluronic acid hydrogel inspired by platelet coagulation provides a multifunctional hemostatic adhesive mediating highly effective hemostasis and preventing abnormal tissue adhesion.

Cited by 91 publications

References 46 publications

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing

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