Hydrogel‐Based Multifunctional Dressing Combining Magnetothermally Responsive Drug Delivery and Stem Cell Therapy for Enhanced Wound Healing

Abstract

Multifunctional dressings are attracting increased interest in the area of tissue engineering and regenerative medicine. Wound healing is a dynamic and complex process that requires multidisciplinary management. However, dressings that exhibit both anti‐infective and tissue regenerative properties are still limited. Herein, a hydrogel‐based multifunctional dressing weaved by drug‐loaded magnetothermally responsive [Fe3O4@SiO2‐interpenetrating polymer network (IPN)] microfibers and human umbilical cord mesenchymal stem cell‐laden microfibers is developed. Magnetothermally responsive microfibers, as smart constructs, can release antibiotics on‐demand to prevent infection, due to the magnetothermal heating effect of the embedded magnetic nanoparticles and the thermoresponsive property of the IPN hydrogels. Furthermore, stem cell‐laden microfibers markedly promote cell proliferation and tissue remodeling, with improved re‐epithelization, granulation tissue formation, and collagen deposition at the wound site. Hydrogel‐based microfibers have the additional ability of absorbing exudate, providing a moist environment, and retaining the therapeutic cells. Therefore, functional microfibers and textiles significantly accelerate the healing process. An advanced dressing for wound healing, incorporating controlled drug delivery and stem cell‐based therapy is developed. Furthermore, the results of the present study reveal the potential of multifunctional dressings in tissue engineering and regenerative medicine.

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

“…12f–h). 214 Owing to the magnetothermal heating effect of the embedded Fe 3 O 4 @SiO 2 , the hydrogel could effectively release loaded antibiotics on-demand to exert antibacterial effects under an external magnetic field (Fig. 12i and j).…”

Advanced Multifunctional Wound Dressing Hydrogels as Drug Carriers

“…[95] In another study, a multifunctional dressing containing human umbilical cord mesenchymal stem cells (HUMSCs)laden microfibers was developed based on Fe 3 O 4 @SiO 2 -IPN microfibers. [96] Fe 3 O 4 @SiO 2 was inserted into magnetothermally responsive microfibers with a magnetothermal heating effect. The release of antibiotic drugs was related to temperature changes.…”

“…Furthermore, the hydrogel dressing absorbed the wound exudate, provided a moist environment, preserved the cells in the defected wound, and significantly facilitated wound healing. [96]…”

Microfluidic-based functional materials: new prospects for wound healing and beyond

“…Zhang et al demonstrated the microfluidic-mediated generation of hydrogel dressing of drug-loaded magnetothermally responsive [Fe 3 O 4 @SiO 2 -interpenetrating polymer network (IPN)] microfibers compounded with human umbilical cord mesenchymal stem cells hUMSCs. 135 The core solution for the preparation of Fe 3 O 4 @SiO 2 -IPN microfibers consisted of sodium alginate, N -isopropylacrylamide (NIPAM), acrylamide (AAm), N , N -methylenebisacrylamide (BIS), ammonium persulfate (APS), and Fe 3 O 4 @SiO 2 nanoparticles, and the shell solution consisted of CaCl 2 and TEMED solution. The microfibers were then freeze-dried and immersed in ciprofloxacin hydrochloride solution for drug loading.…”