A SERS microfluidic chip for ultrasensitive and simultaneous detection of SCCA and CYFRA21-1 in serum based on Au nanobowl arrays and hybridization chain reaction

Cao, Xiaowei; Gu, Yingyan; Li, Zhiyue; Ge, Shengjie; Mao, Yu; Gu, Yuexing; Lü, Dan

doi:10.1016/j.snb.2022.132894

Cited by 14 publications

(2 citation statements)

References 46 publications

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“…[1][2][3][4] For this purpose, a variety of biosensors based on different technologies have been developed for sensing various kinds of biomarkers and have exhibited good stability, reliability, and efficiency. [5][6][7][8][9][10][11][12][13][14] However, most of them rely on expensive analytical equipment and timeconsuming processes, which are inconvenient for practical use, especially for monitoring multiple parameters. To address these issues, many kinds of novel biosensors with lower cost and higher sensitivity have been presented, such as nanoparticles, [15][16][17][18] quantum dots (QDs), [19][20][21] and colloidal crystal materials.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

Wang,

Zhang,

Bian

et al. 2023

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Colloidal crystals are materials self‐assembled from the colloidal nanoparticles. Due to the ordered microstructure, they exhibit significant optical properties and have shown huge potential in the field of biosensing. Besides, the unique macroscopic shapes can also play a critical role in the sensing process. Here, we present a comprehensive discussion on the colloidal crystal‐based biosensors with different topological shapes, including the development strategies of currently reported colloidal crystal particles, films, and fibers, and their recent progress in biosensing. In addition, the faced challenges and the possible solutions are also concluded and discussed. We expect this review can enrich the knowledge and encourage the communication of interdisciplinary researchers, thus promoting the further development and practical applications of colloidal crystal‐based biosensors.

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Section: Introductionmentioning

confidence: 99%

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

Wang,

Zhang,

Bian

et al. 2023

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“…Unlike nanoparticle structures, noble-metal nanobowl (NB) structures can more effectively bind multiple forms of the “hot spot” to enhance their surface-localized electric-field strength and produce powerful Raman signals [ 20 , 21 , 22 , 23 , 24 , 25 ]. Simulation calculations indicate that the NB’s upper edge and bottom position can cause lightning-rod effects and resonance-coupling effects to produce large enhancement fields [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Silver Nanobowl Arrays on Patterned Sapphire Substrate for Surface-Enhanced Raman Scattering

Pang

Jin

2023

Micromachines

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The current article discusses surface-enhanced Raman spectroscopy (SERS) as a powerful technique for detecting molecules or ions by analyzing their molecular vibration signals for fingerprint peak recognition. We utilized a patterned sapphire substrate (PSS) featuring periodic micron cone arrays. Subsequently, we prepared a three-dimensional (3D) PSS-loaded regular Ag nanobowls (AgNBs) array using self-assembly and surface galvanic displacement reactions based on polystyrene (PS) nanospheres. The SERS performance and structure of the nanobowl arrays were optimized by manipulating the reaction time. We discovered that the PSS substrates featuring periodic patterns exhibited superior light-trapping effects compared to the planar substrates. The SERS performance of the prepared AgNBs-PSS substrates was tested under the optimized experimental parameters with 4-mercaptobenzoic acid (4-MBA) as the probe molecule, and the enhancement factor (EF) was calculated to be 8.96 × 104. Finite-difference time-domain (FDTD) simulations were conducted to explain that the AgNBs arrays’ hot spots were distributed at the bowl wall locations. Overall, the current research offers a potential route for developing high-performance, low-cost 3D SERS substrates.

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Surface‐Enhanced Raman Spectroscopy‐Based Optical Biosensor for Liquid Biopsy: Toward Precision Medicine

Fan,

Weng,

Liu

et al. 2024

Laser & Photonics Reviews

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Liquid biopsy is regarded as a promising strategy for assisting precision medicine because of its convenience, noninvasiveness, and ability to overcome tumor heterogeneity and achieve early detection. Recently, impressive advancements in plasmonic biosensors, artificial intelligence, and portable Raman equipment have yielded unprecedented progress in surface‐enhanced Raman spectroscopy (SERS)–based point‐of‐care testing (POCT) systems for liquid biopsy. The development of these systems presents a paradigm shift in on‐site liquid biopsy applications by leveraging the unique benefits of efficiency, fast analysis, portability, affordability, and user‐friendliness. Herein, these advances are introduced over the last 3 years in the field of SERS‐based POCT systems for labeled and label‐free biomarker analysis in body fluids, including tumor circulating proteins and cells, exosomes, micro‐RNA, and circulating tumor DNA. Additionally, powerful machine learning algorithms (including deep learning algorithms) are integrated with SERS to effectively extract potential data features and generate precise diagnostic models. The review highlights the use of handheld and portable Raman devices in significantly promoting the application of SERS‐based POCT in clinical scenarios. Finally, the review outlines the challenges and future perspectives of this technology.

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A SERS microfluidic chip for ultrasensitive and simultaneous detection of SCCA and CYFRA21-1 in serum based on Au nanobowl arrays and hybridization chain reaction

Cited by 14 publications

References 46 publications

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

Bioinspired bioassay platforms derived from colloidal crystals with topological shapes

Fabrication of Silver Nanobowl Arrays on Patterned Sapphire Substrate for Surface-Enhanced Raman Scattering

Surface‐Enhanced Raman Spectroscopy‐Based Optical Biosensor for Liquid Biopsy: Toward Precision Medicine

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