A sex chromatin survey of newborn children in two London hospitals.

Clustering of Trisomy 18 in Kuwait: Genetic Predisposition or Environmental?

“…18 The birth prevalence rate of Edwards' syndrome varies considerably, from 1:3000 to 1:11,000 live births. 2,3,7,[19][20][21][22][23][24] In the present study, the T18 average birth prevalence rate was 8.95 per 10,000 live births, which is significantly higher than the previous rate reported from Kuwait during 1984-1985 (1.1 per 10,000) and in 1986 (4.61 per 10,000). 25 Although clustering of births of children with Edwards' syndrome has been previously reported, no studies reported such a high rate.…”

A case of double aneuploidy, 47,XXY,14-,t(13q14q)+, also probably homozygous for the cystic fibrosis gene.

“…Double aneuploids of this constitution have been found frequently since; an incidence at birth as high as one per 11,614 males has been estimated by Taylor and Moores (1967); it has been suggested that strong selection against such double aneuploids operates in early life (Hecht et al, 1969).…”

Psychiatric Disturbances in Turner’s Syndrome

“…[2,3,13,19,22,31,32], EEG anomalies are likewise found in a high proportion of the patients: all the cases re ported by G unnel [13] and half of those of L indsten [19] exhibit abnor mal tracings. G odinova [12] showed in three out of seven patients moderate diffuse alterations, i. e. rapid dysrhythmia intermingled with slow activity, and D ummermuth [8] found EEG alterations in six out of seven cases, in three of the cases a hypersynchronous activity appearing (one case also presented clinical epilepsy).…”

“…The rare occurrence of Turner's disease among the population in gen eral (rarer than the Klinefelter and the triplo-X syndromes) [14,32] and the low incidence of oligophrenia or of severe mental disturbances in this condition explain why the hospital psychiatrist is seldom faced with a case of Turner's syndrome.…”