A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis

Jin, Jiayang; Li, Jing; Hou, Meiling; Ding, Xu; Zhong, Yan; He, Jing; Sun, Xiaolin; Ye, Hua; Li, Ru; Wu, Lijun; Wang, Jun; Guo, Jianping; Li, Zhanguo

doi:10.1128/spectrum.03662-22

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…Similar to the microbiomes of SLE patients, those of RA patients included several bacterial genera that correlated with immune responses. These included Rhizorhapis, Stenotrophomonas , and Alcaligenes , which were associated with plasma cells, serum LBP, and/or sCD14 ( Jin et al., 2023 ) These studies illustrate interactions between urinary microbiome, metabolome, and immune response in autoimmune diseases and its associated complications including UTIs.…”

Section: Introductionmentioning

confidence: 95%

“…Elevated incidence of UTIs has been observed in rheumatoid arthritis patients ( Mowat et al., 1970 ; Tishler et al., 1992 ; Ebringer and Rashid, 2006 ). Jin and co-authors ( Jin et al., 2023 ) studied the urogenital microbiome of RA patients, revealing a dysbiotic state in comparison to non-affected controls; genera positively correlated with disease included Rhizorhapis, Stenotrophomonas, and Alcaligenes ( Jin et al., 2023 ). Furthermore, Proteus a known cause of UTI, was detected in in the urogenital microbiome of RA patients ( Ebringer and Rashid, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

“…These findings indicate that urine metabolites could be a potential diagnostic test to differentiate between SLE and control. Jin and colleagues studied the urogenital microbiome in RA patients and noticed a negative association between citric acid and the genus Proteus in the urobiome ( Jin et al., 2023 ). Citric acid is associated with proinflammatory factors in macrophages ( Infantino et al., 2014 ) and Proteus is highly prevalent during UTI in RA patients ( Mowat et al., 1970 ).…”

Section: Introductionmentioning

confidence: 99%

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Urine microbiome in individuals with an impaired immune system

Elsayed,

Wolfe,

Burk

2024

Front. Cell. Infect. Microbiol.

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With the advent of next generation sequencing, it is now appreciated that human urine is not sterile. Recent investigations of the urinary microbiome (urobiome) have provided insights into several urological diseases. Urobiome dysbiosis, defined as non-optimal urine microbiome composition, has been observed in many disorders; however, it is not clear whether this dysbiosis is the cause of urinary tract disorders or a consequence. In addition, immunologically altered disorders are associated with higher rates of urinary tract infections. These disorders include immunoproliferative and immunodeficiency diseases, cancer, and immunosuppressant therapy in transplant recipients. In this review, we examine the current state of knowledge of the urobiome in immunologically altered diseases, its composition and metabolomic consequences. We conclude that more data are required to describe the urobiome in immune altered states, knowledge that could facilitate understanding the role of the urobiome and its pathophysiological effects on urinary tract infections and other disorders of the urinary tract.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Urine microbiome in individuals with an impaired immune system

Elsayed,

Wolfe,

Burk

2024

Front. Cell. Infect. Microbiol.

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Rheumatoide Arthritis und das intestinale Mikrobiom – Ein potentieller Faktor in der Pathogenese der RA

Heidt,

Reuss-Borst

2023

Aktuelle Rheumatologie

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ZusammenfassungDie rheumatoide Arthritis (RA) ist eine chronische, entzündliche, systemische Autoimmunerkrankung, die chronisch progredient verläuft und zu schweren strukturellen Schäden und Funktionseinschränkungen führen kann. Ihre Pathogenese ist komplex und nicht abschließend verstanden. Neben genetischen, scheinen vor allem Umweltfaktoren eine wichtige Rolle zu spielen. Der Darm bildet die „innere Grenze“ zur Umwelt und kommt mit vielen Umweltfaktoren in Kontakt. Daher rückt der Darm in den letzten Jahren und mit ihm das Mikrobiom zunehmend (wieder) in den Fokus der Wissenschaft. Immer mehr evidente Befunde zeigen, dass die Mikrobiom-Darm-Gelenk-Achse eine wichtige Rolle bei der RA darstellt. Mikrobielle Dysbiose sowie eine intakte Darmbarriere („leaky gut“) und daraus resultierende bakterielle Translokation stellen potentielle Faktoren in der RA-Pathogenese dar. Hier fassen wir die derzeit bekannte Rolle der intestinalen Mikrobiota für Entstehung und Verlauf der RA zusammen. Wir betrachten dabei die neuesten Erkenntnisse auf dem Gebiet der Mikrobiomforschung und beschreiben den Zusammenhang zwischen intestinaler Dysbiose, intakte Barrierefunktion, bakterielle Translokation, adaptive Immunantwort sowie einen möglichen diätetischen Therapieansatz.

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The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis

Li,

Jin

et al. 2024

JCI Insight

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Palatine tonsils are the only air-contacted lymphoid organs that constantly engage in crosstalk with commensal microorganisms and serve as the first handling sites against microbial antigens. While tonsil inflammations have been implicated in various autoimmune diseases, including rheumatoid arthritis (RA), the precise role of tonsillar microbiota in autoimmune pathogenesis remains inadequately characterized. In this study, we profiled the tonsillar microbiota and identified a notable dysbiosis in patients with RA, particularly within the Streptococcus genus. Specifically, patients with RA exhibited an enrichment of pathogenic Streptococcus species, including S . pyogenes , S . dysgalactiae , and S . agalactiae . Colonization with these bacteria significantly exacerbated arthritis severity and increased autoimmune responses in collagen-induced arthritis (CIA). Furthermore, immunization with peptides derived from these pathogenic Streptococcus species directly induced experimental arthritis. Conversely, patients with RA demonstrated a marked deficiency in commensal Streptococcus members, notably S . salivarius . Treatment of CIA mice with S . salivarius attenuated the progression of arthritis and downregulated autoimmune responses. These findings highlight a pathogenic link of tonsillar microbiota with RA, shedding light on their contribution to autoimmunity.

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A Shifted Urinary Microbiota Associated with Disease Activity and Immune Responses in Rheumatoid Arthritis

Abstract: We revealed that the profile of the urinary tract microbiota in RA featured with increased microbial richness and shifted taxa, associated with immunological and metabolic changes of the disease, underlining the interplay between urinary microbiota and host autoimmunity.

Cited by 6 publications

References 41 publications

Urine microbiome in individuals with an impaired immune system

Urine microbiome in individuals with an impaired immune system

Rheumatoide Arthritis und das intestinale Mikrobiom – Ein potentieller Faktor in der Pathogenese der RA

The aberrant tonsillar microbiota modulates autoimmune responses in rheumatoid arthritis

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