A “Ship in a Bottle” Strategy To Load a Hydrophilic Anticancer Drug in Porous Metal Organic Framework Nanoparticles: Efficient Encapsulation, Matrix Stabilization, and Photodelivery

Nunzio, Maria Rosaria di; Agostoni, Valentina; Cohen, Boiko; Gref, Ruxandra; Douhal, Abderrazzak

doi:10.1021/jm4017202

Cited by 103 publications

(89 citation statements)

References 48 publications

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“…161 Cytotoxicity assays in HepG2 and MCF-7 cells showed that AL-UiO-66 NMOFs induced enhanced cell killing than free AL. The delivery of camptothecin (CPT) and its derivative Topotecan (TPT) was achieved by ZIF-8 (∼70 nm) 162 and MIL-100 (∼50−100 nm), 163 respectively. Both drug loaded NMOFs exhibited enhanced cytotoxicity against cancer cells as compared to free drugs.…”

Section: Doxorubicin (Dox)mentioning

confidence: 99%

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

2015

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Section: Doxorubicin (Dox)mentioning

confidence: 99%

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

2015

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“…[11][12][13] Others have been designed to emit white light for developing white light emitting devices (WLEDs). 18,19 The formed host-guests composites materials can exhibit different photoevents processes as charge-and energy-transfer (CT, ET). 16,17 For both MOFs, the immobilization of the organic linkers by its incorporation into the network leads to an increase in the internal as well as external quantum yields, improving their photoluminescence properties, like luminescent and moisture stability and color tunability.…”

Section: Introductionmentioning

confidence: 99%

Efficient multicolor and white light emission from Zr-based MOF composites: spectral and dynamic properties

2015

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We report on the spectroscopy and dynamics of a Zr-naphthalene dicarboxylic acid (Zr-NDC) MOF interacting with three laser dyes: Coumarin 153 (C153), Nile Red (NR) and 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran (DCM) in diethyl ether (DE) suspensions. The photoexcitation of the MOF forming the composites (dyes@MOF) leads to an energy transfer (ET) to the trapped dyes, opening the door to tune the materials emission. Trapped C153 molecules exhibit two different ET dynamics. At lower C153 concentrations, the mean ET time process (from MOF monomers) is in ~3.3 ns, whereas at higher ones it is in ~360 ps. These mean ET times, which are guest-concentration dependent, reflect the different dye occupancies into the MOF pores. For trapped NR and DCM molecules, because of a different emission (energy donor) and absorption (energy acceptor) spectral overlap, the ET takes place from the excimers and not from the monomers. Solvent suspensions of Zr-NDC MOF trapping these three dyes show a multicolor, and white light emission, having quantum yields up to 41 %. More specifically, NR/C153@Zr-NDC in diethyl ether suspension gives three emission bands having their intensity maxima at ~385, ~500 and ~660 nm. This combination produces a white light, having CIE coordinates (0.32, 0.34) very near to the ideal ones (0.33, 0.33). Our findings open the door to develop fluorescence nanomaterial sensors and white light LEDs based on Zr-NDC MOF.

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“…16 Other than these, the microenvironment of MOFs which are either hydrophilic or hydrophobic gives them ability to encapsulate both lipophilic as well as lipophobic drugs. 17 Different types of forces play an important role for drug loading and its release. These forces can be Van Der Waals force, hydrogen bonds, coordination bond, pi-pi interactions, electrostatic interaction etc.…”

mentioning

confidence: 99%

Zeolitic Imidazole Framework (ZIF) Nanospheres for Easy Encapsulation and Controlled Release of an Anticancer Drug Doxorubicin under Different External Stimuli: A Way toward Smart Drug Delivery System

2015

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The conventional drug delivery systems made from organic- or inorganic-based materials suffer from some problems associated with uncontrolled drug release, biocompatibility, cytotoxicity, and so forth. To overcome these problems, zeolitic imidazole framework (ZIF) hybrid materials can be one of the solutions. Here, we report a very easy and successful encapsulation of an anticancer drug doxorubicin inside two ZIFs, namely, ZIF-7 and ZIF-8, which are little explored as drug delivery systems, and we studied the controlled release of the drug from these two ZIFs under external stimuli such as change in pH and upon contact with biomimetic systems. Experimental results demonstrate that ZIF-7 remains intact when the pH changes from physiological condition to acidic condition, whereas ZIF-8 successfully releases drug under acidic condition. Interestingly, both the ZIFs are excellent for drug release when they come in contact with micelles or liposomes. In the case of ZIF-8, the drug delivery can be controlled for 3 h, whereas its analogue ZIF-7 delivers the drug for a time span of 10 h. We explained the reluctance of ZIF-7 toward drug release in terms of rigidity. This study highlights that by using different ZIFs and liposomes, the drug release rate can be easily modulated, which implies ample possibility for ZIFs as a good drug delivery system. The study shows a novel strategy for easy drug encapsulation and its release in a controlled manner, which will help future development of the drug delivery system.

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A “Ship in a Bottle” Strategy To Load a Hydrophilic Anticancer Drug in Porous Metal Organic Framework Nanoparticles: Efficient Encapsulation, Matrix Stabilization, and Photodelivery

Cited by 103 publications

References 48 publications

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

Nanomedicine Applications of Hybrid Nanomaterials Built from Metal–Ligand Coordination Bonds: Nanoscale Metal–Organic Frameworks and Nanoscale Coordination Polymers

Efficient multicolor and white light emission from Zr-based MOF composites: spectral and dynamic properties

Zeolitic Imidazole Framework (ZIF) Nanospheres for Easy Encapsulation and Controlled Release of an Anticancer Drug Doxorubicin under Different External Stimuli: A Way toward Smart Drug Delivery System

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