A short review of spiral microfluidic devices with distinct cross-sectional geometries

Ramya, S; Kumar, S Praveen; Ram, G Dinesh; Lingaraja, D

doi:10.1007/s10404-022-02593-5

Cited by 9 publications

(2 citation statements)

References 130 publications

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“…Later, spiral geometry was chosen as a popular structure for microfluidic devices after trying to make a variety of geometries (Figure 2b) [102,103]. This type of structure benefits from simplicity, high efficiency, shorter length, and better controllability [104]. In addition to the low possibility of clogging and blocking in such channels, their separation efficiency and flow rate are high, which originates from the relatively large dimensions and lack of obstacles.…”

Section: Inertial Microfluidic Devices With Different Geometric Designsmentioning

confidence: 99%

Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review

Farahinia

Zhang

Badea

2023

Sensors

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The treatment of cancers is a significant challenge in the healthcare context today. Spreading circulating tumor cells (CTCs) throughout the body will eventually lead to cancer metastasis and produce new tumors near the healthy tissues. Therefore, separating these invading cells and extracting cues from them is extremely important for determining the rate of cancer progression inside the body and for the development of individualized treatments, especially at the beginning of the metastasis process. The continuous and fast separation of CTCs has recently been achieved using numerous separation techniques, some of which involve multiple high-level operational protocols. Although a simple blood test can detect the presence of CTCs in the blood circulation system, the detection is still restricted due to the scarcity and heterogeneity of CTCs. The development of more reliable and effective techniques is thus highly desired. The technology of microfluidic devices is promising among many other bio-chemical and bio-physical technologies. This paper reviews recent developments in the two types of microfluidic devices, which are based on the size and/or density of cells, for separating cancer cells. The goal of this review is to identify knowledge or technology gaps and to suggest future works.

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Section: Inertial Microfluidic Devices With Different Geometric Designsmentioning

confidence: 99%

Recent Developments in Inertial and Centrifugal Microfluidic Systems along with the Involved Forces for Cancer Cell Separation: A Review

Farahinia

Zhang

Badea

2023

Sensors

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“…We will cover applications that span from separating plasma from blood to the separation of other components of blood including, among others, RBCs, WBCs [58], platelets, biomarkers (e.g., CTCs) [59], and dendritic cells [60]. Different channel configurations have been explored for the separation of blood components, including straight channels, serpentine channels with curved [61] or sharp angles, as well as divergent serpentine microchannels [62] and other serpentine geometry configurations [63], spiral channels [64], and expansion-contraction channels for high throughput hydrodynamic separations.…”

Section: Passive Separation Of Blood Cellsmentioning

confidence: 99%

Microfluidic Blood Separation: Key Technologies and Critical Figures of Merit

Torres-Castro,

Acuña-Umaña,

Lesser-Rojas

et al. 2023

Micromachines

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Blood is a complex sample comprised mostly of plasma, red blood cells (RBCs), and other cells whose concentrations correlate to physiological or pathological health conditions. There are also many blood-circulating biomarkers, such as circulating tumor cells (CTCs) and various pathogens, that can be used as measurands to diagnose certain diseases. Microfluidic devices are attractive analytical tools for separating blood components in point-of-care (POC) applications. These platforms have the potential advantage of, among other features, being compact and portable. These features can eventually be exploited in clinics and rapid tests performed in households and low-income scenarios. Microfluidic systems have the added benefit of only needing small volumes of blood drawn from patients (from nanoliters to milliliters) while integrating (within the devices) the steps required before detecting analytes. Hence, these systems will reduce the associated costs of purifying blood components of interest (e.g., specific groups of cells or blood biomarkers) for studying and quantifying collected blood fractions. The microfluidic blood separation field has grown since the 2000s, and important advances have been reported in the last few years. Nonetheless, real POC microfluidic blood separation platforms are still elusive. A widespread consensus on what key figures of merit should be reported to assess the quality and yield of these platforms has not been achieved. Knowing what parameters should be reported for microfluidic blood separations will help achieve that consensus and establish a clear road map to promote further commercialization of these devices and attain real POC applications. This review provides an overview of the separation techniques currently used to separate blood components for higher throughput separations (number of cells or particles per minute). We present a summary of the critical parameters that should be considered when designing such devices and the figures of merit that should be explicitly reported when presenting a device’s separation capabilities. Ultimately, reporting the relevant figures of merit will benefit this growing community and help pave the road toward commercialization of these microfluidic systems.

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